HIF
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Hypoxia inducible factors (HIFs) are heterodimeric proteins belonging to the basic helix-loop-helix-PAS (bHLH/PAS) family of transcription factors that mediate the primary transcriptional response to stress caused by hypoxia (accessible O2 level < 2%). HIFs are characterized by containing two subunits, including O2-labile α subunit (HIFα) and constitutively expressed β subnit (HIFβ). Mammalian HIFα consists of three isoforms, including HIF1α, HIF2α and HIF3α, which play an essential role in the regulation of HIF activity by O2 availability. Under normal O2 tension, HIFα is hydroxylated at the two conserved proline residues within the O2-dependent degradation (ODD) domain by prolylhydroxylase domain proteins (PHDs) and undergoes proteosomal degradation catalyzed by a complex formed by E3 ubiquitin ligase and the von Hippel-Lindau protein (pVHL); while, under hypoxia, HIFα stabilizes with PHDs being deactivated and hence induce transcription of genes with adaptive functions.
Products Related to HIF(59)
- GC10046Molidustat (BAY85-3934)CAS: 1154028-82-6Purity: >99.00%
Molidustat (BAY85-3934) (BAY 85-3934) is a novel inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PH) with mean IC50 values of 480 nM for PHD1, 280 nM for PHD2, and 450 nM for PHD3.
- GC11031PX-478 2HClCAS: 685898-44-6Purity: >98.00%
PX-478 is a selective inhibitor that suppresses constitutive and hypoxia-induced HIF-1α levels.
- GC11767Hydralazine HClCAS: 304-20-1Purity: >99.50%
Hydralazine HCl is a orally active antihypertensive agent, reduces peripheral resistance directly by relaxing the smooth muscle cell layer in arterial vessel.
- GC14282AKBA (3-acetyl-11-keto-β-Boswellic Acid)CAS: 67416-61-9Purity: >98.00%
AKBA (3-acetyl-11-keto-β-Boswellic Acid) is a pentacyclic triterpene acid that effectively and non-competitively inhibits 5-lipoxygenase (5-LOX), exhibiting various biological activities including anti-inflammatory, antitumor, and neuroprotective effects.
- GC15379JNJ-42041935CAS: 1193383-09-3Purity: >99.50%
Hypoxia-inducible factor (HIF) prolyl hydroxylase (PHD) inhibitor
- GC15473AmifostineCAS: 20537-88-6Purity: >98.00%
Amifostine, an inorganic thiophosphate, is a selective broad-spectrum cytoprotector of normal tissues.
- GC16647Daprodustat(GSK1278863)CAS: 960539-70-2Purity: >98.00%
Daprodustat(GSK1278863) (GSK1278863) is an orally active hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor being developed for the treatment of anemia associated with chronic kidney disease.
- GC30263Glucosamine (D-Glucosamine)CAS: 3416-24-8Purity: >98.00%
Glucosamine (D-Glucosamine) (D-Glucosamine (D-Glucosamine)) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement.
- GC31230Dencichin (Dencichine)CAS: 5302-45-4Purity: >98.00%
Dencichin is a non-protein amino acid originally extracted from Panax notoginseng, and can inhibit HIF-prolyl hydroxylase-2 (PHD-2) activity.
- GC31358HIF-2α-IN-1CAS: 1799948-06-3Purity: >99.50%
HIF-2α-IN-1 is a HIF-2α inhibitor has an IC50 of less than 500 nM in HIF-2α scintillation proximity assay.
- GC32083AcriflavineCAS: 8048-52-0Purity: >98.00%
Acriflavine is a fluorescent dye for labeling high molecular weight RNA.
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GC10046 | Molidustat (BAY85-3934) | 1154028-82-6 | >99.00% | |
Molidustat (BAY85-3934) (BAY 85-3934) is a novel inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PH) with mean IC50 values of 480 nM for PHD1, 280 nM for PHD2, and 450 nM for PHD3. | ||||
| GC11031 | PX-478 2HCl | 685898-44-6 | >98.00% | |
PX-478 is a selective inhibitor that suppresses constitutive and hypoxia-induced HIF-1α levels. | ||||
| GC11767 | Hydralazine HCl | 304-20-1 | >99.50% | |
Hydralazine HCl is a orally active antihypertensive agent, reduces peripheral resistance directly by relaxing the smooth muscle cell layer in arterial vessel. | ||||
| GC12255 | IOX4 | 1154097-71-8 | >99.50% | |
PHD2 inhibitor | ||||
| GC12487 | Adaptaquin | 385786-48-1 | >98% | |
HIF-prolyl hydroxylase-2 (PHD2) inhibitor | ||||
| GC12821 | Oltipraz | 64224-21-1 | >99.50% | |
Oltipraz is an HIF-1α inhibitor (IC 50 =10μM) and an Nrf2 activator. | ||||
| GC14282 | AKBA (3-acetyl-11-keto-β-Boswellic Acid) | 67416-61-9 | >98.00% | |
AKBA (3-acetyl-11-keto-β-Boswellic Acid) is a pentacyclic triterpene acid that effectively and non-competitively inhibits 5-lipoxygenase (5-LOX), exhibiting various biological activities including anti-inflammatory, antitumor, and neuroprotective effects. | ||||
| GC15379 | JNJ-42041935 | 1193383-09-3 | >99.50% | |
Hypoxia-inducible factor (HIF) prolyl hydroxylase (PHD) inhibitor | ||||
| GC15473 | Amifostine | 20537-88-6 | >98.00% | |
Amifostine, an inorganic thiophosphate, is a selective broad-spectrum cytoprotector of normal tissues. | ||||
| GC16195 | 2,4-DPD | 41438-38-4 | >98% | |
Diethyl pyridine-2,4-dicarb is a potent prolyl 4-hydroxylase-directed proinhibitor. | ||||
| GC16638 | FG2216 | 223387-75-5 | >99.00% | |
HIF-prolyl hydroxylase inhibitor | ||||
| GC16647 | Daprodustat(GSK1278863) | 960539-70-2 | >98.00% | |
Daprodustat(GSK1278863) (GSK1278863) is an orally active hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor being developed for the treatment of anemia associated with chronic kidney disease. | ||||
| GC16811 | Vadadustat | 1000025-07-9 | >98.00% | |
HIF-PH inhibitor | ||||
| GC17358 | Octyl-α-ketoglutarate | 876150-14-0 | >95.00% | |
prolyl hydroxylases (PHD) activator | ||||
| GC18236 | Echinomycin | 512-64-1 | >95.00% | |
An inhibitor of HIF1mediated gene transcription | ||||
| GC19251 | MK-8617 | 1187990-87-9 | >98.00% | |
MK-8617 is an orally active pan-inhibitor of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) with an IC50 of 1 nM for PHD2. | ||||
| GC30263 | Glucosamine (D-Glucosamine) | 3416-24-8 | >98.00% | |
Glucosamine (D-Glucosamine) (D-Glucosamine (D-Glucosamine)) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement. | ||||
| GC31230 | Dencichin (Dencichine) | 5302-45-4 | >98.00% | |
Dencichin is a non-protein amino acid originally extracted from Panax notoginseng, and can inhibit HIF-prolyl hydroxylase-2 (PHD-2) activity. | ||||
| GC31358 | HIF-2α-IN-1 | 1799948-06-3 | >99.50% | |
HIF-2α-IN-1 is a HIF-2α inhibitor has an IC50 of less than 500 nM in HIF-2α scintillation proximity assay. | ||||
| GC31498 | TP0463518 | 1558021-37-6 | >98.00% | |
TP0463518 is a potent hypoxia-inducible factor prolyl hydroxylases (PHDs) inhibitor | ||||
| GC32083 | Acriflavine | 8048-52-0 | >98.00% | |
Acriflavine is a fluorescent dye for labeling high molecular weight RNA. | ||||
| GC32228 | Tilorone dihydrochloride | 27591-69-1 | >99.50% | |
An interferon-inducing antiviral agent | ||||
| GC32449 | Desidustat | 1616690-16-4 | >98.00% | |
An inhibitor of HIF-PH | ||||
| GC32680 | PT-2385 | 1672665-49-4 | >99.00% | |
PT-2385 is a selective HIF-2α inhibitor with a Ki of less than 50 nM. | ||||