GN44028 |
| Catalog No.GC34595 |
A HIF-1 inhibitor
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1421448-26-1
Sample solution is provided at 25 µL, 10mM.
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GN44028 is a hypoxia inducible factor (HIF)-1 inhibitor, with an IC50 of 14 nM. GN44028 inhibits hypoxia-induced HIF-1α transcriptional activity without suppressing HIF-1α mRNA expression, HIF-1α protein accumulation, or HIF-1α/HIF-1β heterodimerization[1]. IC50: 14 nM (HIF-1)[1].
[1]. Minegishi H, et al. Discovery of Indenopyrazoles as a New Class of Hypoxia Inducible Factor (HIF)-1 Inhibitors. ACS Med Chem Lett. 2013 Jan 27;4(2):297-301.
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