HCV Protease
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Hepatitis C virus (HCV) protease is an enzyme, either viral or cellular, that catalyzes the hydrolysis of the long polyprotein precursor (approximately 3000 amino acids) encoded by HCV genome into at least ten individual proteins, including four structural proteins (C, E1, E2 and p7) and six nonstructural (NS) proteins (NS2, NS3, NS4A, NS4B, NS5A and NS5B). The commonly studied HCV proteases are two virally encode proteases involved in the viral replication of HCV, including HCV NS2/3 protease, a highly hydrophobic protease responsible for the cleavage of NS2 and NS3, and HCV NS3-4A serine protease, a covalent heterodimer responsible for cleavage at four sites of the HCV polyprotein.
Products Related to HCV Protease(37)
- GC14074NarlaprevirCAS: 865466-24-6Purity: >98.00%
Narlaprevir is a highly selective and orally active inhibitor of the hepatitis C virus non-structural protein 3 (HCV NS3), with a K i value of 6nM and an EC 90 value of 40nM.
- GC17701Clemizole hydrochlorideCAS: 1163-36-6Purity: >99.50%
An antihistamine and TRPC5 channel blocker
- GC19165GlecaprevirCAS: 1365970-03-1Purity: >98.00%
Glecaprevir is a novel HCV NS3/4A protease inhibitor, with IC50 values ranging from 3.5 to 11.3 nM.
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GC12057 | Daclatasvir (BMS-790052) | 1214735-16-6 | >98% | |
HCV NS5A inhibitor | ||||
| GC10155 | Vaniprevir | 923590-37-8 | >98% | |
| GC10832 | VX-222 (VCH-222, Lomibuvir) | 1026785-59-0 | >98% | |
An HCV polymerase inhibitor | ||||
| GC10930 | Balapiravir | 690270-29-2 | >98% | |
| GC10959 | Boceprevir | 394730-60-0 | >98.00% | |
An NS3/4A protease inhibitor | ||||
| GC11463 | MK-5172 sodium salt | 1425038-27-2 | >98% | |
| GC11840 | Ciluprevir (BILN-2061) | 300832-84-2 | >98% | |
Inhibitor of HCV NS3 protease | ||||
| GC12236 | Daclatasvir dihydrochloride | 1009119-65-6 | >99.50% | |
An NS5A inhibitor | ||||
| GC12299 | Telaprevir (VX-950) | 402957-28-2 | >98.00% | |
An HCV NS3/4A protease inhibitor | ||||
| GC12444 | Clemizole | 442-52-4 | >98% | |
An antihistamine and TRPC5 channel blocker | ||||
| GC12879 | Danoprevir (RG7227) | 850876-88-9 | >99.50% | |
An HCV NS3/4A protease inhibitor | ||||
| GC13312 | HZ-1157 | 1009734-33-1 | >98.50% | |
HCV NS3/4A protease inhibitor | ||||
| GC14074 | Narlaprevir | 865466-24-6 | >98.00% | |
Narlaprevir is a highly selective and orally active inhibitor of the hepatitis C virus non-structural protein 3 (HCV NS3), with a K i value of 6nM and an EC 90 value of 40nM. | ||||
| GC14458 | Asunaprevir (BMS-650032) | 630420-16-5 | >99.50% | |
An HCV NS3/4A protease inhibitor | ||||
| GC14937 | Anguizole | 442666-98-0 | >99.50% | |
| GC15891 | Nesbuvir | 691852-58-1 | >98.50% | |
| GC16098 | MK-5172 hydrate | 1350462-55-3 | >99.00% | |
| GC16887 | Tegobuvir | 1000787-75-6 | >98.00% | |
A non-nucleoside inhibitor of HCV NS5B | ||||
| GC16901 | PSI-6206 | 863329-66-2 | >99.50% | |
An inactive derivative of a HCV NS5B inhibitor | ||||
| GC17114 | MK-5172 potassium salt | 1206524-86-8 | >99.00% | |
| GC17270 | Simeprevir | 923604-59-5 | >99.50% | |
A potent NS3/4A protease inhibitor | ||||
| GC17701 | Clemizole hydrochloride | 1163-36-6 | >99.50% | |
An antihistamine and TRPC5 channel blocker | ||||
| GC18004 | MK-5172 | 1350514-68-9 | >99.50% | |
MK-5172 is a selective inhibitor of hepatitis C virus (HCV) NS3/4a protease, exhibiting broad-spectrum activity against multiple genotypes and drug-resistant variants, and capable of inhibiting SARS-CoV-2 3CL protease activity. | ||||
| GC19165 | Glecaprevir | 1365970-03-1 | >98.00% | |
Glecaprevir is a novel HCV NS3/4A protease inhibitor, with IC50 values ranging from 3.5 to 11.3 nM. | ||||