GLPBio

Hedgehog

Hh (Hedgehog) signalling is a evolutionarily conserved pathway that is critical for embryonic development, tissue and organ morphogenesis. Mammalian Hh protein ligands include Sonic Hh, Desert Hh and Indian Hh. Dysfunctions of Hh singalling lead to developmental abnormalities and cancer.

Products Related to Hedgehog(43)

  • GC10359 structure
    GC10359GANT61
    CAS: 500579-04-4
    Purity: >98.00%

    GANT61 was able to efficiently block GLI1 as well as GLI2-induced transcription, IC50 is 5 µM.

  • GC11045 structure
    GC11045HPI 1
    CAS: 599150-20-6
    Purity: >94.00%

    HPI 1 is a potent GLI antagonist with an IC50 value of 1.1 μM. HPI 1 shows anti-proliferative activity. HPI 1 decreases the GLI1 mRNA expression. HPI 1 inhibits colony formation in a dose-dependent manner.

  • GC11111 structure
    GC11111Jervine
    CAS: 469-59-0
    Purity: >99.00%

    Hedgehog signaling Inhibitor

  • GC11193 structure
    GC11193SANT-2
    CAS: 329196-48-7
    Purity: >98.00%

    SANT-2 is a potent antagonist of Hh-signaling pathway. Hedgehog (Hh) signaling plays an important role in cell signaling of embryonic development and adult tissue homeostasis. SANT-2 has the potential for the research of several malignancies including Gorlin syndrome (a disorder predisposing to basal cell carcinoma, medulloblastoma and rhabdomyosarcoma), prostate, pancreatic and breast cancers.

  • GC11476 structure
    GC11476Ciliobrevin A
    CAS: 302803-72-1
    Purity: >99.50%

    Hh pathway antagonist

  • GC12429 structure
    GC12429AY 9944 dihydrochloride
    CAS: 366-93-8
    Purity: >98.00%

    AY 9944 dihydrochloride is a specific cholesterol biosynthesis inhibitor.

  • GC13280 structure
    GC13280PF-5274857
    CAS: 1373615-35-0
    Purity: >98.00%

    Smo antagonist,potent and selective

  • GC13441 structure
    GC13441Cyclopamine
    CAS: 4449-51-8
    Purity: >99.50%

    Cyclopamine is a naturally occurring Hedgehog (Hh)-specific small-molecule signaling steroidal alkaloid inhibitor, causes a profound inhibition of tumor growth, has significant anti-invasive, anti-proliferative and anti-estrogenic potency in human breast cancer cells .

  • GC14715 structure
    GC14715AZ 12080282 dihydrochloride
    Purity: >98.00%

    Hedgehog inhibitor

  • GC15256 structure
    GC15256JK 184
    CAS: 315703-52-7
    Purity: >99.50%

    Hh signaling inhibitor

  • GC15683 structure
    GC15683LY2940680
    CAS: 1258861-20-9
    Purity: >99.50%

    LY2940680 (LY2940680) is an antagonist of the smoothened receptor.

  • GC15889 structure
    GC15889SANT-1
    CAS: 304909-07-7
    Purity: >99.50%

    SANT-1 is a cell-permeable Smoothened antagonist that inhibits the Hedgehog pathway.

  • GC17153 structure
    GC17153CHIR-99021 (CT99021) HCl
    CAS: 1797989-42-4
    Purity: >99.00%

    Laduviglusib (CHIR-99021) monohydrochloride is a potent and selective GSK-3α/β inhibitor with IC50s of 10 nM and 6.7 nM. CHIR-99021 (CT99021) HCl shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. CHIR-99021 (CT99021) HCl is also a potent Wnt/β-catenin signaling pathway activator. CHIR-99021 (CT99021) HCl enhances mouse and human embryonic stem cells self-renewal. CHIR-99021 (CT99021) HCl induces autophagy.

  • GC10493 structure
    GC10493GDC-0449 (Vismodegib)
    CAS: 879085-55-9
    Purity: >98.00%

    GDC-0449 (Vismodegib) is an orally active and highly selective Smoothened (SMO) receptor inhibitor that suppresses the Hedgehog signaling pathway with an IC 50 value of 3.0nM. It also inhibits the activity of P-gp and ABCG2, with IC 50 values of 3.0μM and 1.4μM, respectively.

  • GC11217 structure
    GC11217CUR 61414
    CAS: 334998-36-6
    Purity: >99.00%

    potent inhibitor of hedgehog-induced cellular activity

  • GC12068 structure
    GC12068SAG
    CAS: 912545-86-9
    Purity: >99.50%

    SAG (Smoothened Agonist) is an effective Smo receptor agonist.

  • GC13630 structure
    GC13630MK-4101
    CAS: 935273-79-3
    Purity: >98.00%

    Hedgehog (Hh) signaling pathway inhibitor

  • GC15284 structure
    GC15284U 18666A
    CAS: 3039-71-2
    Purity: >98.00%

    U18666A is a small molecule with cellular permeability and amphiphilism that inhibits 3β-hydroxysterol-Δ (24)-reductase (DHCR24) activity, thereby preventing cholesterol outflow from late endosomes and lysosomes.

  • GC15422 structure
    GC1542220(S)-Hydroxycholesterol
    CAS: 516-72-3
    Purity: >98.00%

    20(S)-Hydroxycholesterol is a selective allosteric activator of the Hedgehog pathway protein Smoothened (EC 50 =3μM).

  • GC16789 structure
    GC16789GANT 58
    CAS: 64048-12-0
    Purity: >99.50%

    An inhibitor of Gli transcription

  • GC17713 structure
    GC17713Oxy-16
    CAS: 596-94-1
    Purity: >98%

    Oxy-16 is an endogenous metabolic intermediate.

  • GC18475 structure
    GC18475Robotnikinin
    CAS: 1132653-79-2
    Purity: >98%

    Sonic hedgehog (Shh) is the most widely characterized of the three vertebrate Hedgehog homologs, and is essential for proper embryonic development.

  • GC37573 structure
    GC37573RU-SKI 43
    CAS: 1043797-53-0
    Purity: >98%

    RU-SKI 43 is a potent and selective Hedgehog acyltransferase (Hhat) inhibitor with an IC50 of 850 nM. RU-SKI 43 reduces Gli-1 activation through Smoothened-independent non-canonical signaling and decreases Akt and mTOR pathway activity. RU-SKI 43 has anti-cancer activity.

  • GC38522 structure
    GC38522Neurodazine
    CAS: 937807-66-4
    Purity: >98%

    Small molecule inducer of neuronal differentiation