Men 10376 TFA (Synonyms: Neurokinin-2 receptor antagonist TFA) |
| カタログ番号GC36582 |
Men 10376 TFA は選択的タキキニン NK-2 受容体アンタゴニストであり、ラット小腸 NK-2 受容体に対する Ki は 4.4 μM です 。
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Men 10376 TFA is a selective tachykinin NK-2 receptor antagonist, with a Ki of 4.4 μM for rat small intestine NK-2 receptor[1]. Ki: 4.4 μM (NK-2 receptor, rat small intestine)[1]
Men 10376 is a selective tachykinin NK-2 receptor, with a Ki of 4.4 μM, and shows low selectivity for NK-1 and NK-3 receptors (Ki, >10 μM)[1]. Men 10376 shows pA2s of 5.66 and 8.08 for NK-1 (guinea-pig ileum) and NK-2 receptors (endothelium-deprived rabbit pulmonary artery). Men 10376 shows no effect on NK-3 receptor (Ki, >10 μM)[2].
Men 10376 (1 and 3 μmol/kg) antagonizes increase in bladder motility produced by the NK-2 receptor agonist in rats[2].
[1]. Quartara L, et al. N-terminal truncated analogs of men 10376 as tachykinin NK-2 receptor antagonists. Life Sci. 1992;51(25):1929-36. [2]. Maggi CA, et al. In vivo evidence for tachykininergic transmission using a new NK-2 receptor-selective antagonist, MEN 10,376. J Pharmacol Exp Ther. 1991 Jun;257(3):1172-8.
| Cas No. | SDF | ||
| 同義語 | Neurokinin-2 receptor antagonist TFA | ||
| Formula | C59H69F3N12O12 | M.Wt | 1195.25 |
| 溶解度 | Water: 1.43 mg/mL (1.20 mM) | Storage | -20°C, protect from light |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 0.8366 mL | 4.1832 mL | 8.3665 mL |
| 5 mM | 0.1673 mL | 0.8366 mL | 1.6733 mL |
| 10 mM | 0.0837 mL | 0.4183 mL | 0.8366 mL |
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- Purity: >99.50%
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Average Rating: 5 (Based on Reviews and 31 reference(s) in Google Scholar.)
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