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JAK

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Janus kinases (JAKs), belonging to a distinct family of tyrosine kinases, are non-receptor tyrosine kinases that transduce signals of cytokine receptors via diverse signal transduction pathways. Mammalian JAK family consists of four structurally similar members, JAK1, JAK2, JAK3 and Tyrosine kinase 2 (TYK2), which are characterized by containing seven JAK homology (JH) domains. The presence of JH1 and JH2 domains is the most intriguing feature of JAK proteins. JH1 domain is the main catalytic domain; while JH2 is usually considered as a catalytically inactive pseudokinase domain. However, results of recent studies have shown that JH2 acts as a dual-specificity protein kinase to phosphorylate two regulatory sites (Ser523 and Tyr570) in JAK2.

Products Related to JAK(188)

  • GC73148 structure
    GC73148JAK-IN-21
    CAS: 2445499-20-5
    Purity: >99.00%

    JAK-IN-21(例4)は、jak1、jak2、j2v617f、tyk2に対してic50sをそれぞれ1.73、2.04、109、62.9 nmの選択的かつ強力なjak阻害剤である。

  • GC73369 structure
    GC73369SJ988497
    CAS: 2595365-41-4
    Purity: >98.00%

    SJ988497はPROTAC JAK 2分解剤である。

  • GC73456 structure
    GC73456JAK1-IN-11
    CAS: 2427608-43-1
    Purity: >98.00%

    JAK1-IN-11(化合物11)はjakの強力な阻害剤であり、ic50はそれぞれ0.02 nm (jak1)と0.44 nm (jak2)である。

  • GC73475 structure
    GC73475JAK-IN-26
    CAS: 2417134-93-9
    Purity: >98.00%

    JAK-IN-26（化合物2）は経口活性JAK阻害剤であり、良好な薬物動態特性を有する。

  • GC73600 structure
    GC73600JAK3-IN-14
    CAS: 454234-24-3
    Purity: >99.00%

    JAK3-IN-14（化合物1）は強力なJAK 3阻害剤であり、JAK 3とJAK 2のIC 50値はそれぞれ38と600 nMである。

  • GC73627 structure
    GC73627HDAC/JAK/BRD4-IN-1
    CAS: 2755325-84-7
    Purity: >95.00%

    HDAC/JAK/BRD4-IN-1（化合物25 ap）は強力なHDAC/JAK/BRD 4三重阻害剤である。

  • GC79003 structure
    GC79003WCY-8-67 TFA
    Purity: >99.00%

    WCY-8-67 TFA is an orally active and selective USP5 inhibitor, with an IC 50 value of 1.33 μM.

  • GC79070 structure
    GC79070WWQ-03-012
    CAS: 3076807-15-0
    Purity: >98.00%

    WWQ-03-012 is a selective DESI2 inhibitor with an IC 50 of 47.3 nM.

  • GC79181 structure
    GC79181RAI-20
    CAS: 2549180-90-5
    Purity: >98.50%

    RAI-20 (H018) is an orally active JAK1/JAK2 dual inhibitor ( IC 50 =15.1 and 22.7 nM).

  • GC80468 structure
    GC80468Peficitinib-d 3
    Purity: >98.00%

    Peficitinib -d 3 (ASP015K-d 3 ) is the deuterium labeled Peficitinib.

  • GC80946 structure
    GC80946PROTAC JAK1/2 degrader-1
    Purity: >99.00%

    PROTAC JAK1/2 degrader-1 is an orally active JAK1 / JAK2 PROTAC degrader, with DC 50 values of 1.4 μM and 0.92 μM against JAK1 and JAK2, respectively.

  • GC80947 structure
    GC80947JAK1/2 ligand 1
    CAS: 1026028-96-5
    Purity: >99.50%

    JAK1/2 ligand 1 is a ligand for the PROTAC target protein of JAK1/2, which can be used to synthesize PROTAC JAK1/2 degrader-1.

  • GC81026 structure
    GC81026PROTAC SKP2 Degrader-1
    CAS: 3120650-15-6
    Purity: >99.50%

    PROTAC SKP2 Degrader-1 is a PROTAC degrader targeting SKP2, with a K d value of 6.28 μM.

  • GC91059 structure
    GC91059LCC-12 (formate)
    Purity: >98.00%

    銅（II）キレーターであり、メトホルミンの誘導体

  • GC91148 structure
    GC91148JAK Inhibitor 31
    CAS: 2891469-99-9
    Purity: >98.00%

    JAK2阻害剤

  • GC91506 structure
    GC91506Bayer 18
    CAS: 1251752-12-1
    Purity: >98.00%

    Bayer 18 is a tyrosine kinase 2 (TYK2) inhibitor (IC50 = 18.7 nM).

  • GC91689 structure
    GC91689TG46
    CAS: 936091-15-5
    Purity: >98.00%

    TG46 is an inhibitor of JAK2 (IC50 = 12.5 µM).

  • GN10442 structure
    GN10442Curculigoside
    CAS: 85643-19-2
    Purity: >99.50%
  • GN10584 structure
    GN10584Ginsenoside Rk1
    CAS: 494753-69-4
    Purity: >98.00%
  • GN10627 structure
    GN10627Atractylenolide I
    CAS: 73069-13-3
    Purity: >98.00%