TTFB (Synonyms: N-(4-tert-butyl-1,3-thiazol-2-yl)-3-fluorobenzamide) |
カタログ番号GC81728
One-Click Copy Product Info
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TTFB (N-(4-tert-butyl-1,3-thiazol-2-yl)-3-fluorobenzamide) is a selective, non-competitive zinc-activated channel ( ZAC ) antagonist.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 352560-76-0
Sample solution is provided at 25 µL, 10mM.
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In Vitro, TTFB (0.1-100 μM; 30 seconds) potently inhibits Zn2+-evoked, H+-evoked, and spontaneous ZAC activity in Xenopus oocytes with IC50 values of 3.0 μM, 8.5 μM, and 4.7 μM, respectively, and mediates complete inhibition of Zn2+-induced responses[1]. TTFB (10 μM) mediates ZAC inhibition that is voltage-independent, as it inhibits H+-evoked currents similarly at -60 mV and +60 mV[1].
References:
[1]. Madjroh N, et al. Discovery and functional characterization of N-(thiazol-2-yl)-benzamide analogs as the first class of selective antagonists of the Zinc-Activated Channel (ZAC). Biochem Pharmacol. 2021;193:114782.
| Cas No. | 352560-76-0 | SDF | |
| 同義語 | N-(4-tert-butyl-1,3-thiazol-2-yl)-3-fluorobenzamide | ||
| Formula | C14H15FN2OS | M.Wt | 278.35 |
| 溶解度 | Storage | Store at -20°C | |
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.5926 mL | 17.963 mL | 35.926 mL |
| 5 mM | 718.5 μL | 3.5926 mL | 7.1852 mL |
| 10 mM | 359.3 μL | 1.7963 mL | 3.5926 mL |
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Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)