WX2-43 |
カタログ番号GC79149
One-Click Copy Product Info
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WX2-43 is a PRMT5-KLF4 inhibitor ( K d of 11.0 nM).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 723754-14-1
Sample solution is provided at 25 µL, 10mM.
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In Vivo, WX2-43 (40-80 mg/kg; i.p.; twice weekly; 4 weeks) suppresses triple negative breast tumor progression in nude mice[1].
In Vitro, WX2-43 (biotin-WX2-43; 0.1 nM-10 μM; 2 h) binds to PRMT5 with a Kd of 11.0 nM[1]. WX2-43 (0.03-10 μM; 24 h) inhibits cell viability in a KLF4-dependent manner in MEFs treated with cisplatin[1]. WX2-43 is more potent in TNBC cell lines (EC50 0.44-0.96 μM) than in normal mammary epithelial cell lines (EC50 3.62-23.34 μM)[1]. WX2-43 can induce a mesenchymal-like phenotype in two-dimensional (2D) AKPS cultures, altering colony morphology, size, and actin cytoskeleton, and reducing the frequency of Ki-67+ cells[2].
References:
[1]. Zhou Z, et al. A novel small-molecule antagonizes PRMT5-mediated KLF4 methylation for targeted therapy. EBioMedicine. 2019;44:98-111.
[2]. Borrelli C, et al. In vivo interaction screening reveals liver-derived constraints to metastasis. Nature. 2024;632(8024):411-418.
| Cas No. | 723754-14-1 | SDF | |
| Formula | C17H21ClN2 | M.Wt | 288.82 |
| 溶解度 | DMSO: ≥ 100 mg/mL (346.24 mM) | Storage | Store at -20°C |
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.4624 mL | 17.3118 mL | 34.6236 mL |
| 5 mM | 692.5 μL | 3.4624 mL | 6.9247 mL |
| 10 mM | 346.2 μL | 1.7312 mL | 3.4624 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)