>>Signaling Pathways>> PI3K/Akt/mTOR Signaling>>CAY10626

CAY10626

Catalog No.GC18884

CAY10626은 PI3Kα/mTOR 이중 키나제 억제제입니다. CAY10626의 IC50은 0.9, PI3Kα의 경우 0.6nM입니다. 및 mTOR, 각각. CAY10626은 암 연구에 사용할 수 있습니다.

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CAY10626 Chemical Structure

Cas No.: 1202884-94-3

Size 가격 재고 수량
1mg
US$146.00
재고 있음
5mg
US$649.00
재고 있음
10mg
US$1,154.00
재고 있음
25mg
US$2,521.00
재고 있음

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Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents Related Products
Phosphatidylinositol 3-kinase (PI3K) catalyzes the phosphorylation of the 3' hydroxyl position of PIs to produce PtdIns-(3,4)-P2 and PtdIns-(3,4,5)-P3, important second messengers that modulate the activity of downstream targets Akt and mTOR. Aberrant PI3K/Akt is associated with many human cancers. CAY10626 is a potent, dual PI3Kα/mTOR inhibitor with IC50 values of 0.9 and 0.6 nM for the two respective kinases. In a tumor cell growth inhibition assay, CAY10626 demonstrates IC50 values of 50 mg/k to MD361 xenograft mice, phosphorylation of the downstream targets of PI3Kα and mTOR (Akt T308, Akt S473, and S6K) was suppressed, and significant tumor regression was observed.

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Average Rating: 5 ★★★★★ (Based on Reviews and 34 reference(s) in Google Scholar.)

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