Cefoxitin (sodium salt) (Synonyms: Betacef,Cenomycin,Farmoxin,Mefoxin,Merxin) |
| Catalog No.GC16446 |
세폭시틴(나트륨염)(MK-306)은 종종 2세대 세팔로스포린으로 분류되는 세파마이신 항생제로, 세포벽 합성을 방해하여 작용하며, 그 활성 스펙트럼에는 광범위한 그람 음성 및 그람 양성 박테리아가 포함됩니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 33564-30-6
Sample solution is provided at 25 µL, 10mM.
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Cefoxitin (sodium salt) is a second generation cephalosporin antibiotic that was used to treat a wide range of gram-negative and gram-positive bacteria [1][2].
Cefoxitin, 3-carbamoyloxymethyl-7-a-methoxy-7- [2-(2-thienyl)acetamido]-3-cephem-4-carboxylic acid, is a semisynthetic cephamycin antibiotic with broad-spectrum activity. Cefoxitin is also active in vivo against a wide variety of bacteria including penicillin-resistant staphylococci and effective against gram-negative organisms including strains of indole-positive Proteus [1].
In mice, cefoxitin was more active against the cephalosporin-sensitive gram-negative bacteria, strains of E.coli, indole-producing Proteus, and Serratia, and the lactamase producing 2646. Cefoxitin was degraded by the lactamase of E. cloacae at a much slower rate than are the cephalosporins. In pharmacological studies, cefoxitin was found in sera and detected in urine samples in amounts greater than those of cephalothin and less than those of cephaloridine [1].
References:
[1]. Miller AK, Celozzi E, Kong Y, et al. Cefoxitin, a semisynthetic cephamycin antibiotic: in vivo evaluation. Antimicrob Agents Chemother. 1974 Jan;5(1):33-7.
[2]. Jacoby GA. AmpC beta-lactamases. Clin Microbiol Rev.2009 Jan;22(1):161-82.
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