SIS17 |
| Catalog No.GC37643 |
SIS17은 IC50 값이 0.83μM인 포유류 히스톤 데아세틸라제 11(HDAC 11) 억제제로, 다른 HDAC를 억제하지 않고 탈미리스토일화 HDAC11 기질인 세린 하이드록시메틸 트랜스퍼라제 2를 억제합니다.
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Cas No.: 2374313-54-7
Sample solution is provided at 25 µL, 10mM.
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SIS17 is a mammalian histone deacetylase 11 (HDAC 11) inhibitor with an IC50 value of 0.83 μM, inhibits the demyristoylation HDAC11 substrate, serine hydroxymethyl transferase 2, without inhibiting other HDACs[1]. IC50: 0.83 μM (HDAC 11)[1]
[1]. Son SI, et al. Activity-Guided Design of HDAC11-Specific Inhibitors. ACS Chem Biol. 2019 Jul 19;14(7):1393-1397.
Average Rating: 5 (Based on Reviews and 29 reference(s) in Google Scholar.)
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