Angiogenesis

Inositol-1,3,4,5,6-pentaphosphate (Ins(1,3,4,5,6)P5) is one of the many inositol phosphate isomers that act as small, soluble second messengers in the transmission of cellular signals.

The phosphatidylinositol 3-kinase (PI3K)/Akt signal transduction pathway plays critical roles in cell growth and proliferation making it an attractive target for anticancer agents.

Ganglioside GD1a is a sialic acid-containing glycosphingolipid found in brain, erythrocytes, bone marrow, testis, spleen, and liver.

Ganglioside GM3 is a monosialoganglioside that demonstrates antiproliferative and proapoptotic effects in tumor cells by modulating cell adhesion, proliferation, and differentiation.

Fasudil (HA-1077; AT877) 디 하이드로 클로라이드는 비특이적 rhoA/암석 억제제이며 또한 단백질 키나제에 대한 억제 효과가 있으며, 0.33 &7##8886; m 0.158&777###956; offlineefficient_models_2022q2.md;M, 1.650 μM for ROCK2 and PKA, PKC, PKG, respectively.en_ko_2021q1.mdHA-1077 (hydrochloride) is also a potent Ca2+ channel antagonist and vasodilator.en_ko_2021q1.md

Nicotinic acid adenine dinucleotide phosphate (NAADP) is a secondary messenger that induces calcium mobilization.

Nebivolol O-β-D-glucuronide is an active metabolite of the β1-adrenergic receptor antagonist nebivolol.

NSC 12는 FGF2에 결합하고 FGFR1과의 상호작용을 방해하는 섬유아세포 성장 인자 2(FGF2)의 세포외 트랩입니다. NSC 12는 전신 독성 효과 없이 시험관 내 및 생체 내에서 서로 다른 FGF 의존성 종양 세포의 증식을 억제합니다.

NVP-BEZ235 is a potent dual inhibitor of phosphatidylinositol 3-kinase (PI3K) and mTOR that is well tolerated, displays disease stasis when administered orally, and enhances the efficacy of other anticancer agents when used in in vivo combination studies.

PD 168368은 15-45nM의 Ki를 갖는 강력하고 경쟁적이며 선택적인 뉴로메딘 B 수용체(NMB-R) 길항제입니다. PD 168368은 뉴로메딘 B 수용체(NMBR; IC50=96 nM)/가스트린-방출 펩티드 수용체(GRPR IC50=3500 nM) 길항제입니다. PD 168368은 또한 각각 0.57, 0.24 및 2.7nM의 EC50을 갖는 혼합 FPR1/FPR2/FPR3 작용제입니다.

A CysLT 1 and CysLT 2 receptor antagonist

Streptochlorin is a bacterial metabolite originally isolated from Streptomyces sp.

Sucrose octasulfate (SOS), a component of the gastrointestinal protectant sucralfate, is an alkaline aluminum-sucrose complex that inhibits peptic hydrolysis and raises gastric pH, protecting esophageal epithelium against acid injury.

Tie2 Inhibitor 7 blocks Tie2 kinase activity with a Ki value of 1.3 μM..

(±)10(11)-DiHDPA is produced from cytochrome P450 epoxygenase action on docosahexaenoic acid.

A neuropeptide with diverse biological activities

An estrogen sulfamate

도비티닙-D8(CHIR-258-D8)은 도비티닙으로 표지된 중수소입니다. 도비티닙(CHIR-258)은 FLT3, c-Kit, FGFR1/FGFR3, VEGFR1/VEGFR2/에 대해 IC50이 1, 2, 8/9, 10/13/8, 27/210 nM인 다중 표적 티로신 키나제 억제제입니다. 각각 VEGFR3 및 PDGFRα/PDGFRβ.

반데타닙-d6(ZD6474-d6)은 반데타닙으로 표시된 중수소입니다. 반데타닙(D6474)은 VEGFR2/KDR 티로신 키나제 활성(IC50=40nM)의 강력한 경구 활성 억제제입니다. 반데타닙은 또한 VEGFR3/FLT4(IC50=110nM) 및 EGFR/HER1(IC50=500nM)의 티로신 키나제 활성 대 활성을 갖는다.

An internal standard for the quantification of rhein

An internal standard for the quantification of cimetidine

A neuropeptide with diverse biological activities

A neuropeptide with diverse biological activities

18-Deoxyherboxidene(RQN-18690A)은 강력한 혈관신생 억제제입니다.