NSC 12 (Synonyms: NSC 172285) |
| Catalog No.GC44465 |
NSC 12는 FGF2에 결합하고 FGFR1과의 상호작용을 방해하는 섬유아세포 성장 인자 2(FGF2)의 세포외 트랩입니다. NSC 12는 전신 독성 효과 없이 시험관 내 및 생체 내에서 서로 다른 FGF 의존성 종양 세포의 증식을 억제합니다.
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Cas No.: 102586-30-1
Sample solution is provided at 25 µL, 10mM.
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NSC 12 is an extracellular trap for fibroblast growth factor 2 (FGF2) that binds FGF2 (Kd = 51 µM) and interferes with its interaction with FGFR1, without affecting the ability of FGF2 to bind heparin or heparin sulfate proteoglycans (HSPGs). NSC 12 also binds several other, but not all, FGF isoforms with Kd values ranging between 16 and 120 µM, preventing them from forming HSPG/FGF/FGFR ternary complexes. NSC 12 inhibits FGF-dependent angiogenesis and tumor cell proliferation in vitro and reduces tumor growth in mice.
Average Rating: 5 (Based on Reviews and 37 reference(s) in Google Scholar.)
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