Cell Cycle/Checkpoint
Cell Cycle
Cells undergo a complex cycle of growth and division that is referred to as the cell cycle. The cell cycle consists of four phases, G1 (GAP 1), S (synthesis), G2 (GAP 2) and M (mitosis). DNA replication occurs during S phase. When cells stop dividing temporarily or indefinitely, they enter a quiescent state called G0.
Research Areas
- ATM/ATR(28)
- Aurora Kinase(35)
- Cdc42(4)
- Cdc7(3)
- Chk(13)
- c-Myc(52)
- CRM1(10)
- Cyclin-Dependent Kinases(70)
- E1 enzyme(1)
- G-quadruplex(16)
- Haspin(6)
- HMTase(1)
- Kinesin(32)
- Ksp(4)
- Microtubule/Tubulin(301)
- Mps1(17)
- Mitotic(7)
- RAD51(13)
- ROCK(76)
- Rho(13)
- PERK(22)
- PLK(51)
- PTEN(7)
- Wee1(16)
- PAK(29)
- Arp2/3 Complex(10)
- Dynamin(18)
- ECM & Adhesion Molecules(53)
- Cholesterol Metabolism(10)
- Endomembrane System & Vesicular Trafficking(34)
- G1(50)
- G2/M(35)
- G2/S(16)
- Genotoxic Stress(22)
- Inositol Phosphates(65)
- Proteolysis(179)
- Cytoskeleton & Motor Proteins(71)
- Cellular Chaperones(14)
- Cyclin G-associated Kinase (GAK)(2)
- MARK(4)
- NEKs(9)
- ATF6(2)
- ClpP(6)
- Disulfidptosis(1)
- HMG Family(1)
- PDI(1)
- SWI/SNF Complex(7)
- VISTA(4)
- HOXA(1)
Products Related to Cell Cycle/Checkpoint(1540)
- GC4842319-O-Acetylchaetoglobosin ACAS: 50939-69-0Purity: >95.00%
19-O-Acetylchaetoglobosin A는 cytochalasan alkaloid로 C. globosum에서 원래 분리된 곰팡이 대사산물로 액틴 중합 억제 및 세포 독성 활성을 가지고 있습니다. 19-O-아세틸키토글로보신 A는 HeLa 자궁경부암 세포에 세포독성을 나타냅니다.
- GC48471Z-(L-Arg)-AMC (hydrochloride)CAS: 70375-22-3Purity: >98.00%
Z-(L-Arg)-AMC(염산염)는 트립신과 파파인에 대한 형광 기질입니다.
- GC48659UmbellipreninCAS: 532-16-1; 23838-17-7Purity: >98.00%
A prenylated coumarin with diverse biological activities
- GC48688Griseofulvin-d3CAS: 1279033-22-5Purity: >99.00%
An internal standard for the quantification of griseofulvin
- GC48764Sydowinin BCAS: 58450-00-3Purity: >95.00%
A xanthone polyketide with immunosuppressant activity
- GC48848Albendazole-d7CAS: 1287076-43-0Purity: >99.00%
Albendazole-d7(SKF-62979-d7)은 Albendazole로 표시된 중수소입니다.
- GC48901BRD9876CAS: 32703-82-5Purity: >98.00%
BRD9876은 강화된 미세소관(MT) 결합이 있는 상태에서 키네신-5(Eg5)를 고정시켜 MT의 번들링 및 안정화를 유도하는 \BRD9876 is the "rigor" inhibitor that locks kinesin-5 (Eg5) in a state with enhanced microtubules (MTs) binding, leading to bundling and stabilization of MTs.en_ko_2021q1.mdBRD9876 interacts with the tyrosine 104 residue that is part of the α4-α6 allosteric binding pocket.en_ko_2021q1.mdBRD9876 specifically targets microtubule-bound Eg5 and selectively inhibits myeloma over CD34 cells.en_ko_2021q1.mdBRD9876 has the potential for multiple myeloma (MM) research.en_ko_2021q1.md
- GC48968Docetaxel (hydrate)CAS: 700367-34-6Purity: >98.00%
An analog of taxol with antitumor properties
- GC48971AZD 1152 (hydrochloride)CAS: 722543-50-2Purity: >95.00%
A prodrug for a potent Aurora B inhibitor
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GC48387 | Inostamycin A | 129905-10-8 | >90.00% | |
A bacterial metabolite with anticancer activity | ||||
| GC48390 | Z-LRGG-AMC (trifluoroacetate salt) | - | >95.00% | |
| GC48394 | Phomopsinamine | 89085-54-1 | >95.00% | |
An inhibitor of microtubule polymerization | ||||
| GC48401 | Risuteganib (trifluoroacetate salt) | - | >95.00% | |
An anti-integrin peptide | ||||
| GC48418 | N-(2-Poc-ethyl)betulin amide | - | >95.00% | |
| GC48423 | 19-O-Acetylchaetoglobosin A | 50939-69-0 | >95.00% | |
19-O-Acetylchaetoglobosin A는 cytochalasan alkaloid로 C. globosum에서 원래 분리된 곰팡이 대사산물로 액틴 중합 억제 및 세포 독성 활성을 가지고 있습니다. 19-O-아세틸키토글로보신 A는 HeLa 자궁경부암 세포에 세포독성을 나타냅니다. | ||||
| GC48430 | Ac-DEVD-CMK (trifluoroacetate salt) | - | >98.00% | |
| GC48449 | 28-(Poc-amino)betulin | - | >95.00% | |
| GC48470 | Ac-DEVD-CHO (trifluoroacetate salt) | - | >95.00% | |
A dual caspase3/caspase7 inhibitor | ||||
| GC48471 | Z-(L-Arg)-AMC (hydrochloride) | 70375-22-3 | >98.00% | |
Z-(L-Arg)-AMC(염산염)는 트립신과 파파인에 대한 형광 기질입니다. | ||||
| GC48509 | Apigenin 7-O-Glucuronide (hydrate) | - | >95.00% | |
| GC48652 | Olomoucine II | 500735-47-7 | >98.00% | |
A CDK inhibitor | ||||
| GC48659 | Umbelliprenin | 532-16-1; 23838-17-7 | >98.00% | |
A prenylated coumarin with diverse biological activities | ||||
| GC48688 | Griseofulvin-d3 | 1279033-22-5 | >99.00% | |
An internal standard for the quantification of griseofulvin | ||||
| GC48720 | Griseofulvic Acid | 469-54-5 | >95.00% | |
A metabolite of griseofulvin | ||||
| GC48721 | 6-O-Demethyl Griseofulvin | 20168-88-1 | >95.00% | |
A metabolite of griseofulvin | ||||
| GC48764 | Sydowinin B | 58450-00-3 | >95.00% | |
A xanthone polyketide with immunosuppressant activity | ||||
| GC48848 | Albendazole-d7 | 1287076-43-0 | >99.00% | |
Albendazole-d7(SKF-62979-d7)은 Albendazole로 표시된 중수소입니다. | ||||
| GC48901 | BRD9876 | 32703-82-5 | >98.00% | |
BRD9876은 강화된 미세소관(MT) 결합이 있는 상태에서 키네신-5(Eg5)를 고정시켜 MT의 번들링 및 안정화를 유도하는 \BRD9876 is the "rigor" inhibitor that locks kinesin-5 (Eg5) in a state with enhanced microtubules (MTs) binding, leading to bundling and stabilization of MTs.en_ko_2021q1.mdBRD9876 interacts with the tyrosine 104 residue that is part of the α4-α6 allosteric binding pocket.en_ko_2021q1.mdBRD9876 specifically targets microtubule-bound Eg5 and selectively inhibits myeloma over CD34 cells.en_ko_2021q1.mdBRD9876 has the potential for multiple myeloma (MM) research.en_ko_2021q1.md | ||||
| GC48968 | Docetaxel (hydrate) | 700367-34-6 | >98.00% | |
An analog of taxol with antitumor properties | ||||
| GC48969 | Withanone | 27570-38-3 | >90.00% | |
Withanone은 인지 기능 장애 완화에 다기능 신경 보호 효과가 있는 Withania somnifera 뿌리의 활성 성분입니다. | ||||
| GC48971 | AZD 1152 (hydrochloride) | 722543-50-2 | >95.00% | |
A prodrug for a potent Aurora B inhibitor | ||||
| GC48974 | Ac-VEID-AMC (ammonium acetate salt) | - | >95.00% | |
A caspase-6 fluorogenic substrate | ||||
| GC48982 | CD532 | 1639009-81-6 | >98.00% | |
CD532는 IC50이 45nM인 강력한 Aurora A 키나제 억제제입니다. CD532는 Aurora A 키나제 활성을 차단하고 MYCN의 분해를 유도하는 이중 효과가 있습니다. CD532는 또한 AURKA와 직접 상호 작용할 수 있으며 전체적인 형태 변화를 유도합니다. CD532는 암 연구에 사용될 수 있습니다. | ||||