GLPBio

Cell Cycle/Checkpoint

Cell Cycle/Checkpoint

Cell Cycle

Cells undergo a complex cycle of growth and division that is referred to as the cell cycle. The cell cycle consists of four phases, G1 (GAP 1), S (synthesis), G2 (GAP 2) and M (mitosis). DNA replication occurs during S phase. When cells stop dividing temporarily or indefinitely, they enter a quiescent state called G0.

Research Areas

Products Related to Cell Cycle/Checkpoint(1447)

  • GC79009 structure
    GC79009Tubulin polymerization-IN-84
    CAS: 2982893-14-9
    Purity: >99.50%

    Tubulin polymerization-IN-84 inhibits tubulin polymerization by targeting the colchicine-binding pocket, with an IC 50 = 10.9 μM.

  • GC79010 structure
    GC79010DHTP
    CAS: 1620225-37-7
    Purity: >99.00%

    DHTP is a kinesin-13 family of microtubule depolymerases selective allosteric inhibitor that inhibits kinesin-13 ATPase activity and microtubule depolymerization activity.

  • GC79011 structure
    GC790117-Benzoyloxindole
    CAS: 51135-38-7
    Purity: >98%

    7-Benzoyloxindole (Compound 4a) is a tubulin destabilizer.

  • GC79012 structure
    GC79012Microtubule-IN-13
    Purity: >99.50%

    Microtubule-IN-13 (Compound FB2) is a microtubule inhibitor.

  • GC79013 structure
    GC79013ON 01500
    CAS: 592542-50-2
    Purity: >99.00%

    ON 01500 is a tubulin inhibitor with a K d of 21 nM.

  • GC79014 structure
    GC79014Tubulin inhibitor 49 hydrobromide
    Purity: >99.00%

    Tubulin inhibitor 49 (Compound 18) hydrobromide is an inhibitor for tubulin polymerization with an IC 50 of 48 μM.

  • GC79015 structure
    GC79015Iso cephalomannine
    CAS: 173101-54-7
    Purity: >98%

    Iso cephalomannine is a tubulin -targeting cytotoxic agent.

  • GC79016 structure
    GC79016KMG-732
    Purity: >98%

    KMG-732 is a dual-target inhibitor that targets GAK and β-tubulin, with K d values of 12.0 nM and 19.3 μM, respectively.

  • GC79017 structure
    GC79017BJG-05-039
    CAS: 3009849-06-0
    Purity: >98.00%

    BJG-05-039 is an inhibitor targeting PAK1, with an IC 50 of 233 nM against human PAK1.

  • GC79044 structure
    GC79044ATC12
    CAS: 384860-40-6
    Purity: >98%

    ATC12 is a Aurora-A kinase inhibitor.

  • GC79045 structure
    GC79045LY3295668 erbumine
    CAS: 1919888-07-5
    Purity: >98%

    LY3295668 (AK-01) erbumine is a highly specific and orally active inhibitor of Aurora-A kinase with a K i values for AurA and AurB of 0.8 nM and 1038 nM respectively.

  • GC79049 structure
    GC79049CG-1521
    CAS: 674767-29-4
    Purity: >95.50%

    CG-1521 is a histone deacetylase ( HDAC ) inhibitor that stabilizes Ac-Lys373 P53, increases P21 levels and HDAC2 degradation.

  • GC79068 structure
    GC79068Telomeric G4s ligand 2
    CAS: 3094716-52-3
    Purity: >98%

    Telomeric G4s ligand 2 is an orally active, selective ligand of telomeric G-quadruplex (G4), with an IC 50 of 0.4 μM.

  • GC79072 structure
    GC79072MS6076
    Purity: >98%

    MS6076 is a mitochondrial protease ClpP agonist.

  • GC79103 structure
    GC79103Berzosertib hydrochloride
    CAS: 1428935-04-9
    Purity: >98.50%

    Berzosertib (VE-822) hydrochloride is an orally active, CNS-penetrant, and selective ATR kinase inhibitor.

  • GC79108 structure
    GC79108AP4-43
    Purity: >99.50%

    AP4-43 is an orally active CLK1, CLK4, PI3K, DDR1, EGFR and NEK4 inhibitor.

  • GC79109 structure
    GC79109CZS-241 hydrochloride
    Purity: >98.50%

    CZS-241 hydrochloride is an orally active and selective inhibitor of Polo-like Kinase 4 ( PLK4 ) ( IC 50 =2.6 nM).

  • GC79115 structure
    GC79115ROCK2-IN-12
    CAS: 3086603-12-2
    Purity: >98.00%

    ROCK2-IN-12 (Compound A25) is a selective ROCK2 inhibitor with an IC 50 of 7.0 nM for ROCK2 over ROCK1.

  • GC79116 structure
    GC79116NRL-1049 dihydrochloride
    CAS: 1973494-17-5
    Purity: >99.00%

    NRL-1049 dihydrochloride (BA-1049) is a selective and orally active rho-associated protein kinase 2 ( ROCK2 ) inhibitor with an IC 50 of 0.59 μM.

  • GC79117 structure
    GC791178012–3246
    CAS: 421586-94-9
    Purity: >99.50%

    8012-3246 is a selective PLK2 inhibitor with an IC 50 of 774.5 nM.

  • GC79121 structure
    GC79121XL495
    CAS: 3040320-93-9
    Purity: >98%

    XL495 is an potent, selective and orally active PKMYT1 inhibitor.

  • GC79122 structure
    GC79122Opitor-0
    Purity: >98.00%

    Opitor-0 is a OPA1 GTPase inhibitor with an IC 50 of 3.0 μM.

  • GC79123 structure
    GC79123Spire2-FMN2 PPI-IN-1 dihydrochloride
    Purity: >98.50%

    Spire2/FMN2 PPI-IN-1 (Compound 13) dihydrochloride is a selective inhibitory fragment targeting the Spire2-FMN2 interaction, with an IC 50 of 62 μM.

  • GC79129 structure
    GC79129Drp1 peptide inhibitor P110 TFA
    Purity: >99.00%

    Drp1 peptide inhibitor P110 (Compound P110) TFA is a selective Drp1 peptide inhibitor with neuroprotective properties.