HIF
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Hypoxia inducible factors (HIFs) are heterodimeric proteins belonging to the basic helix-loop-helix-PAS (bHLH/PAS) family of transcription factors that mediate the primary transcriptional response to stress caused by hypoxia (accessible O2 level < 2%). HIFs are characterized by containing two subunits, including O2-labile α subunit (HIFα) and constitutively expressed β subnit (HIFβ). Mammalian HIFα consists of three isoforms, including HIF1α, HIF2α and HIF3α, which play an essential role in the regulation of HIF activity by O2 availability. Under normal O2 tension, HIFα is hydroxylated at the two conserved proline residues within the O2-dependent degradation (ODD) domain by prolylhydroxylase domain proteins (PHDs) and undergoes proteosomal degradation catalyzed by a complex formed by E3 ubiquitin ligase and the von Hippel-Lindau protein (pVHL); while, under hypoxia, HIFα stabilizes with PHDs being deactivated and hence induce transcription of genes with adaptive functions.
Products Related to HIF(118)
- GC74310Cyclo(CKLIIF) TFAPurity: >97.00%
Cyclo(CKLIIF) TFA은 산소부족유도인자(HIF) 1과 2의 이중 억제제로, HIF1-α와 HIF2-α PAS-B 구조역에 대한 친화력 KD는 각각 2.6, 2.2μM이다.
- GC79669PHD-1-IN-4CAS: 2009343-19-3Purity: >99.50%
PHD-1-IN-4 is a brain-penetrant PHD-1 inhibitor with an IC 50 of 0.074 μM [1] .
- GC79816CryptolepineCAS: 480-26-2Purity: >98%
Cryptolepine is an orally active multi-potent alkaloid with anti-cancer, anti-bacterial, anti-viral, anti-malarial, anti-inflammatory, anti-hyperglycemic, relieve pain and other properties.
- GC81027PROTAC HIF-1α degrader-2CAS: 3095636-64-6Purity: >98%
PROTAC HIF-1α degrader-2 is a highly efficient and selective PROTAC degrader targeting HIF-1α. PROTAC HIF-1α degrader-2 promotes HIF-1α degradation via the ubiquitin-proteasome pathway by facilitating the formation of a HIF-1α/VHL ternary complex.
- GC815842-Amino-2-deoxy-D-glucopyranoseCAS: 90-77-7Purity: >98.00%
2-Amino-2-deoxy-D-glucopyranose is an isomeric form of Glucosamine.
- GC81602Glucosamine sulfate potassium chlorideCAS: 1296149-08-0Purity: >98.00%
Glucosamine sulfate potassium chloride is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement.
- GN10308Chlorogenic acidCAS: 327-97-9Purity: >98.00%
Chlorogenic acid은 강력한 신경 보호제이고 바이러스, 균, 산소화물과 종양에 대한 효능이 있다. Chlorogenic acid은 또한 포도당과 지질 대사를 조절하고 인슐린 민감성을 향상시키는데 관여하고 있다.
- GN10452PaeoniflorinCAS: 23180-57-6Purity: >98.00%
Paeoniflorin은 미나리아재비과 Paeonia 식물의 뿌리에서 추출된 피난 모노테르펜 글리코사이드로 다양한 생물학적 활성을 가지고 있다.
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GC73945 | DYB-03 | 2982792-85-6 | >99.00% | |
DYB-03 는 경구 활성 HIF-1 α/EZH2 억제제입니다. | ||||
| GC74310 | Cyclo(CKLIIF) TFA | - | >97.00% | |
Cyclo(CKLIIF) TFA은 산소부족유도인자(HIF) 1과 2의 이중 억제제로, HIF1-α와 HIF2-α PAS-B 구조역에 대한 친화력 KD는 각각 2.6, 2.2μM이다. | ||||
| GC78962 | MS1129 | - | >98% | |
MS1129 is a DNMT degrader that induces proteasomal degradation of DNMT1, DNMT3A and DNMT3B proteins. | ||||
| GC79574 | mCPX | 1351572-56-9 | >98% | |
mCPX is a prodrug of the antifungal agent Ciclopirox olamine (CPX). | ||||
| GC79669 | PHD-1-IN-4 | 2009343-19-3 | >99.50% | |
PHD-1-IN-4 is a brain-penetrant PHD-1 inhibitor with an IC 50 of 0.074 μM [1] . | ||||
| GC79670 | ZG-2686 | 1795110-22-3 | >98% | |
ZG-2686 is a potent and selective HIF-2α agonist with an EC 50 of 0.25 µM. | ||||
| GC79671 | HIF-IN-2 | 1040535-05-4 | >95.00% | |
HIF-IN-2 is a HIF/HIF prolyl hydroxylase inhibitor. | ||||
| GC79816 | Cryptolepine | 480-26-2 | >98% | |
Cryptolepine is an orally active multi-potent alkaloid with anti-cancer, anti-bacterial, anti-viral, anti-malarial, anti-inflammatory, anti-hyperglycemic, relieve pain and other properties. | ||||
| GC80483 | IOX2-NH2 | 931400-77-0 | >98.00% | |
IOX2 -NH2 (example 115) is a derivative of IOX2. | ||||
| GC80928 | NP1192 | 2966791-41-1 | >99.00% | |
NP1192 is a potent, selective PROTAC NAT10 degrader. | ||||
| GC81027 | PROTAC HIF-1α degrader-2 | 3095636-64-6 | >98% | |
PROTAC HIF-1α degrader-2 is a highly efficient and selective PROTAC degrader targeting HIF-1α. PROTAC HIF-1α degrader-2 promotes HIF-1α degradation via the ubiquitin-proteasome pathway by facilitating the formation of a HIF-1α/VHL ternary complex. | ||||
| GC81031 | NEO-811 | 3084635-77-5 | >98% | |
NEO-811 is a selective and orally active ARNT (HIF-1β) molecular glue degrader. | ||||
| GC81447 | ALDOA-IN-1 | - | >98.00% | |
ALDOA-IN-1 is an aldolase A (ALDOA) inhibitor. | ||||
| GC81584 | 2-Amino-2-deoxy-D-glucopyranose | 90-77-7 | >98.00% | |
2-Amino-2-deoxy-D-glucopyranose is an isomeric form of Glucosamine. | ||||
| GC81595 | BCS12 | 329719-71-3 | >99.50% | |
BCS12 is a CAIX inhibitor. | ||||
| GC81602 | Glucosamine sulfate potassium chloride | 1296149-08-0 | >98.00% | |
Glucosamine sulfate potassium chloride is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement. | ||||
| GC81639 | SH-26 | - | >98% | |
SH-26 is a PHD1 PROTAC degrader with DC 50 s of 1.06 μM, 4.16 μM and 4.91 μM in MDA-MB-231, HepG2 and HEK-293T cells, respectively. | ||||
| GC91083 | Tiopronin-Cysteine Disulfide | 77591-18-5 | >95.00% | |
티오프로닌의 대사산물 | ||||
| GN10308 | Chlorogenic acid | 327-97-9 | >98.00% | |
Chlorogenic acid은 강력한 신경 보호제이고 바이러스, 균, 산소화물과 종양에 대한 효능이 있다. Chlorogenic acid은 또한 포도당과 지질 대사를 조절하고 인슐린 민감성을 향상시키는데 관여하고 있다. | ||||
| GN10452 | Paeoniflorin | 23180-57-6 | >98.00% | |
Paeoniflorin은 미나리아재비과 Paeonia 식물의 뿌리에서 추출된 피난 모노테르펜 글리코사이드로 다양한 생물학적 활성을 가지고 있다. | ||||
| GN10518 | Chitosamine hydrochloride | 66-84-2 | >98.00% | |
| GN10669 | Glucosamine sulfate | 29031-19-4 | >98.00% | |