PI3K/Akt/mTOR Signaling

KTC1101 는 경구 활성 pan-PI3K 억제제의 일종이다.

MTX-531 EGFR(IC50은 14.7nM)과 PI3K(PI3K α, PI3K 베타, PI3K 감마, PI3K 델타를 억제하는 IC50 값은 각각 6.4, 233, 8.3, 1.1nM)로 항종양 작용을 한다.

PIKfyve-IN-3 (화합물 L22) 는 PIKfyve 효소와 뚜렷한 상호작용을 하며 Kd 값은 0.47nM이다.

DNA-PK-IN-12(화합물 31t)는 경구용 활성 DNA-PK 억제제로, IC50은 0.1nM이다.

ASCT2-IN-1 (화합물 20k)은 IC50 값이 있는 ASCT2 억제의 5. 6 μ M과 3. 5 μ M 세포 A549 그리고 HEK293, 각각이다.

ASCT2-IN-2 (화합물 25e) 는 ASCT2 억제제로서 IC50은 5.14 μM입니다.

ARM165는 일종의 이쌍관능분자이다.

Leniolisib-d5 는 일종의 듀테륨 세대 표기인 Leniolisib이다.

(R)-(+)-O-Demethylbuchenavianine 는 세포 주기 단백질 의존성 효소 CDK의 억제제입니다.

WRX606은 mTOR complex 1 (mTORC1)의 억제제이다.

NN3201 is a c-Kit -targeting antibody-drug conjugate ( ADC ) with high affinity ( K D = 0.19 pM).

ACT001 (Dimethylaminomicheliolide; DMAMCL) hydrochloride is an orally active, blood-brain barrier-permeable anti-inflammatory and anti-tumor agent.

HBS-101 is a selectively, orally active, brain-penetrant, Midkine (MDK) inhibitor ( K D = 38.4 nM).

WCY-8-67 TFA is an orally active and selective USP5 inhibitor, with an IC 50 value of 1.33 μM.

DDO-6600 is a covalent Hsp90 inhibitor.

(Rac)-Chem-0199 is the racemic mixture of Chem-0199.

AP4-43 is an orally active CLK1, CLK4, PI3K, DDR1, EGFR and NEK4 inhibitor.

CK2-TN03 is an ATP-competitive casein kinase 2 ( CK2 ) inhibitor, with an IC 50 of 165 nM and a K i of 20 nM.

8012-3246 is a selective PLK2 inhibitor with an IC 50 of 774.5 nM.

T7 Peptide TFA is a protein synthesis inhibitor and anti-angiogenic agent, with a K d of 10 nM for human transferrin receptor.

AMPK activator 19 (Compound 57), alkene oxindole derivative, is an AMPK activator.

ARUK2010489 (Compound 23) is a potent, selective and brain-penetrant NUAK1 inhibitor with a pIC 50 of 8.7.

AMPK activator 18 is a potent allosteric activator of AMPK complexes containing the β2 isoform.

Peptide R54 acetate (Pep R54 acetate) is a CXCR4 antagonist.