GLPBio

TDI-012804

Catalog No.: GC84184Purity:>99.50%
COASDSData Sheet
TDI-012804 is a TNKS2 inhibitor that selectively inhibits intracellular endogenous TNKS2 protein.

제품은 연구용으로만 사용됩니다. 인체에 사용할 수 없으며 환자에게 판매하지 않습니다.

TDI-012804
Cas No.: 3120102-92-0
10mM (in 1mL DMSO)In Stock
$1,846.00
1
1mgIn Stock
$576.00
1
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    641, 529–536 (2025)
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제품 설명 (Description)

TDI-012804 is a TNKS2 inhibitor that selectively inhibits intracellular endogenous TNKS2 protein. TDI-012804 increases the expression of AXIN1 protein in cells that are heterozygous (Tnks1HET) and completely knocks out (Tnks1KO) for TNKS1. TDI-012804 inhibits the proliferation of ApcQ1405X/Tnks1KO organoids ( EC 50 of 59.1 nM) and is selectively toxic to Tnks1KO AKP-G12D and AKP-G13D organoids [1].

References:
[1]. Jill Zimmerman, et al. A potent and selective TNKS2 inhibitor for tumor-selective WNT suppression. bioRxiv.2025 Mar 7:2025.03.04.641305.

제품 문서 (Product Documents)

Purity:>99.50%Appearance:A solid
COASDSData Sheet

화학적 특성 (Chemical Properties)

CAS 번호
3120102-92-0
분자식
C30H26N4O4
분자량
506.55
용해도
DMSO: 100 mg/mL (197.41 mM; Need ultrasonic)
보관
Store at 4°C, sealed storage, away from moisture
배송 조건
평가용 샘플은 아이스팩과 함께 배송됩니다. 그 외 용량은 실온 배송되며, 요청 시 아이스팩과 함께 배송할 수 있습니다.

계산 도구 (Calculators)몰 농도 / 희석 / 분자량 / 단위 변환 / 생체 내 제형 / 용해도

g/mol

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