Lovastatin
Catalog No.: GC11633Purity:>99.50%Synonyms: (+)-Mevinolin, Monacolin K, NSC 633781
Lovastatin is a 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that impacts the mevalonate pathway, which has an IC50 value of 77nM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 75330-75-5
10mM (in 1mL DMSO)In Stock
$42.00
1
50mgIn Stock
$39.00
1
| Pack Size | Price | Availability | Quantity | Action |
|---|---|---|---|---|
| 10mM (in 1mL DMSO) | $42.00 | In Stock | 1 | |
| 50mg | $39.00 | In Stock | 1 |
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com
Citations
3 publicationsPublications from researchers using this productDescription
Lovastatin is a 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that impacts the mevalonate pathway[1], which has an IC50 value of 77nM[2]. Lovastatin can inhibit cholesterol synthesis[3], EC50 value is 0.002mg/kg[2].
Lovastatin can induce apoptosis (10μM , 24h) inspontaneously immortalized rat brain neuroblasts[4]. Lovastatin efficiently inhibited Ras activation,which was associated with a significant decrease in ERK1/2 (extracellular-signalregulated kinase1/2) phosphorylation[4] . Lovastatin can inhibit A549 (human lung adenocarcinoma cells) cell proliferation (50μM , 24h) by regulating the ERK1/2 and COX-2 pathways[5].
Lovastatin (5mg/kg ; 14 days ; Intraperitoneal injection) attenuates hippocampal cell death in Pilocarpine-induced status epilepticus rat model through downregulation of the pro-apoptotic Mst1 gene[6]. Lovastatin (0.5mg/kg ; 10 days ; subcutaneous injection) enhanced ovarian activity throughout follicular development in ICR mice model[7].
Scheme of Low-Density Lipoprotein Receptor（LDLR）activity signaling pathway for follicular development with lovastatin stimulates steroidogenesis in ovaries[7].
References:
[1] AMADASU E, KANG R, USMANI A, et al. Effects of Lovastatin on Brain Cancer Cells [J]. Cell Transplant, 2022, 31(9636897221102903.
[2] H BISCHOFF R A, M BOBERG, D PETZINNA, D SCHMIDT, W STEINKE, G THOMAS. Preclinical review of cerivastatin sodium--a step forward in HMG-CoA reductase inhibition [J]. 1998,
[3] BORUTA T, BIZUKOJC M. Production of lovastatin and itaconic acid by Aspergillus terreus: a comparative perspective [J]. World J Microbiol Biotechnol, 2017, 33(2): 34.
[4] CEREZO-GUISADO M I, GARCIA-ROMAN N, GARCIA-MARIN L J, et al. Lovastatin inhibits the extracellular-signal-regulated kinase pathway in immortalized rat brain neuroblasts [J]. Biochem J, 2007, 401(1): 175-83.
[5] LIU S, YANG P, WANG M, et al. Inhibitory effect of lovastatin on human lung cancer cell proliferation by regulating the ERK1/2 and COX-2 pathways [J]. Transl Cancer Res, 2022, 11(4): 813-22.
[6] ABDANIPOUR A, DEHESHJO F, SOHRABI D, et al. Neuroprotective effect of lovastatin through down-regulation of pro-apoptotic Mst1 gene expression in rat model pilocarpine epilepsy [J]. Neurol Res, 2018, 40(10): 874-82.
[7] KIM Y J, CHO Y I, JANG J, et al. Lovastatin, an Up-Regulator of Low-Density Lipoprotein Receptor, Enhances Follicular Development in Mouse Ovaries [J]. Int J Mol Sci, 2023, 24(8).
Protocol
|
Cell experiment[1]: |
|
|
Cell lines |
Human Pancreatic ductal adenocarcinoma (PDAC) lines： MIA-PaCa-2 (MIA) . |
|
Preparation method |
The cells were cultured in Dulbecco’s Modified Eagle’s Medium supplemented with 10% fetal bovine serum at 37℃ in 5% CO2 . The cells were treated with 0.5μM Lovastatine within 48h . |
|
Reaction Conditions |
0.5μM within 48h . |
|
Applications |
Lovastatin increased mitochondrial oxidative stress in PDAC cells , leading to apoptosis. |
|
Animal experiment[2]: |
|
|
Animal models |
Male Wistar rats . |
|
Preparation method |
Rat model epilepsy was induced by an intraperitoneal injection of pilocarpine (350-400mg/kg for 30min) . All injections of Lovastatin were administered intraperitoneally in a final 0.5ml volume, 3 days following the first seizure on a daily basis for 14 days . |
|
Dosage form |
5mg/kg ; 14 days ; Intraperitoneal injection. |
|
Applications |
Lovastatin attenuates hippocampalcell death in Pilocarpine-induced status epilepticus rat model through downregulation of the pro-apoptotic Mst1 gene. |
|
References: [1] GYOTEN M, LUO Y, FUJIWARA-TANI R, et al. Lovastatin Treatment Inducing Apoptosis in Human Pancreatic Cancer Cells by Inhibiting Cholesterol Rafts in Plasma Membrane and Mitochondria [J]. Int J Mol Sci, 2023, 24(23): [2] ABDANIPOUR A, DEHESHJO F, SOHRABI D, et al. Neuroprotective effect of lovastatin through down-regulation of pro-apoptotic Mst1 gene expression in rat model pilocarpine epilepsy [J]. Neurol Res, 2018, 40(10): 874-82. |
|
Product Documents
Purity:>99.50%Appearance:A solid
Chemical Properties
CAS No.
75330-75-5
Synonyms
(+)-Mevinolin, Monacolin K, NSC 633781
Chemical Name
[(1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate
SMILES
CCC(C)C(=O)OC1CC(C=C2C1C(C(C=C2)C)CCC3CC(CC(=O)O3)O)C
Molecular Formula
C24H36O5
Molecular Weight
404.54
Solubility
≥ 20.2 mg/mL in DMSO, ≥ 18.6 mg/mL in EtOH with ultrasonic
Storage
Store at -20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.
CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility
g/mol
Reviews
Review for Lovastatin
Rating: 5
- 5 Star100%
- 4 Star0%
- 3 Star0%
- 2 Star0%
- 1 Star0%