UDP-GalNAz disodium (Synonyms: UDP-N-azidoacetylgalactosamine disodium) |
| Catalog No.GC64868 |
UDP-GalNAz disodium (UDP-N-azidoacetylgalactosamine disodium) is an analog of UDP-GalNAc. UDP-GalNAc serves as a critical precursor for various glycosylation reactions and functions as a donor substrate for many N-acetylgalactosaminyltransferases, which transfer GalNAc from the nucleotide sugar to carbohydrate or peptide acceptors.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 653600-61-4
Sample solution is provided at 25 µL, 10mM.
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UDP-GalNAz disodium (UDP-N-azidoacetylgalactosamine disodium) is an analog of UDP-GalNAc. UDP-GalNAc serves as a critical precursor for various glycosylation reactions and functions as a donor substrate for many N-acetylgalactosaminyltransferases, which transfer GalNAc from the nucleotide sugar to carbohydrate or peptide acceptors[1]. As a substrate for UDP-GalNAc polypeptide N-acetylgalactosaminyltransferases (GalNAc-Ts), UDP-GalNAc enables GalNAc-Ts to catalyze mucin-type O-glycosylation by transferring α-GalNAc from UDP-GalNAc to serine (Ser) or threonine (Thr) residues of target proteins. This process plays a vital role in regulating high-density lipoprotein cholesterol levels and influences lipid metabolism[2]. UDP-GalNAc also acts as a precursor for the synthesis of Escherichia coli K4 capsular polysaccharides. Metabolic engineering of E. coli K4 strains using UDP-GalNAc can enhance the production of fructose chondroitin[3]. Additionally, UDP-GalNAc serves as a substrate for β-N-acetylhexosaminidases, generating precursors for the cyst wall of Entamoeba histolytica, thereby aiding in understanding the biochemical interactions of this parasite within the colon environment[4]. Furthermore, UDP-GalNAc functions as a substrate for human blood group A glycosyltransferase, driving the biosynthesis of blood group A antigens[5].
References：
[1] Willems A P, Van Engelen B G, Lefeber D J. Genetic defects in the hexosamine and sialic acid biosynthesis pathway[J]. Biochim Biophys Acta, 2016, 1860(8): 1640-54.
[2] Guo L, Zhou L, Wei P, et al. Emerging Roles of UDP-GalNAc Polypeptide N-Acetylgalactosaminyltransferases in Cardiovascular Disease[J]. Aging Dis, 2024, 16(1): 239-49.
[3] Restaino O F, Di Lauro I, Cimini D, et al. Monosaccharide precursors for boosting chondroitin-like capsular polysaccharide production[J]. Appl Microbiol Biotechnol, 2013, 97(4): 1699-709.
[4] Nagode A, Vanbeselaere J, Dutkiewicz Z, et al. Molecular characterisation of Entamoeba histolytica UDP-glucose 4-epimerase, an enzyme able to provide building blocks for cyst wall formation[J]. PLoS Negl Trop Dis, 2023, 17(8): e0011574.
[5] Seto N O, Compston C A, Szpacenko A, et al. Enzymatic synthesis of blood group A and B trisaccharide analogues[J]. Carbohydr Res, 2000, 324(3): 161-9.
| Cas No. | 653600-61-4 | SDF | |
| Synonyms | UDP-N-azidoacetylgalactosamine disodium | ||
| Formula | C17H24N6Na2O17P2 | M.Wt | 692.33 |
| Solubility | Storage | Store at -20°C, away from moisture | |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 1.4444 mL | 7.222 mL | 14.444 mL |
| 5 mM | 0.2889 mL | 1.4444 mL | 2.8888 mL |
| 10 mM | 0.1444 mL | 0.7222 mL | 1.4444 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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