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Na+/K+ ATPase

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Na+/K+ ATPase (Sodium potassium pump) is a transmembrane protein complex found in all higher eukaryotes acting as a key energy-consuming pump maintaining ionic and osmotic balance in cells. Na+/K+ ATPase is an emerging cancer target that merits further investigation.

The constant activity of the Na+/K+-ATPase (NKA, or Na+ pump) is essential for re-establishing and maintaining this gradient. In cardiac and vascular smooth muscle the principal isoforms of the NKA are α1 and α2 and their physiological role is controlled both by their unique and independent signalling pathways, and their discrete subcellular distribution.

Products Related to Na+/K+ ATPase(30)

  • GC10579 structure
    GC10579Ouabain Octahydrate
    CAS: 11018-89-6
    Purity: >99.50%

    Ouabain Octahydrate is a Na + /K + -ATPase inhibitor that can be used to study congestive heart failure.

  • GC11448 structure
    GC11448Istaroxime
    CAS: 203737-93-3
    Purity: >98%
  • GC12413 structure
    GC12413Rostafuroxin (PST 2238)
    CAS: 156722-18-8
    Purity: >98.00%

    Rostafuroxin (PST 2238) (PST 2238), a digitoxigenin derivative, is an orally active and potent Na+,K+-ATPase (ATP1A1) antognist.

  • GC13108 structure
    GC13108Digoxin
    CAS: 20830-75-5
    Purity: >98.00%

    Digoxin is a potent Na + /K + -ATPase inhibitor clinically used to treat arrhythmias and heart failure.

  • GC13162 structure
    GC13162Prilocaine hydrochloride
    CAS: 1786-81-8
    Purity: >98%

    Local anesthetic of the amino amide type

  • GC15071 structure
    GC15071Prilocaine
    CAS: 721-50-6
    Purity: >99.00%

    local anesthetic of the amino amide type

  • GC17086 structure
    GC17086Chlorpropamide
    CAS: 94-20-2
    Purity: >99.50%

    Oral antihyperglycemic agent

  • GC17786 structure
    GC17786Istaroxime hydrochloride
    CAS: 374559-48-5
    Purity: >99.00%
  • GC18189 structure
    GC18189Marinobufagenin
    CAS: 470-42-8
    Purity: >99.00%

    Marinobufagenin is a strong inhibitor of Na+/K+ ATPase that has been identified in mammalian plasma.

  • GC18203 structure
    GC18203Annonacin
    CAS: 111035-65-5
    Purity: >98.00%

    Annonacin is a mitochondrial complex I inhibitor that induces features of tau pathology.

  • GC19522 structure
    GC19522Sodium oleate
    CAS: 143-19-1
    Purity: >97.00%

    Sodium oleate (Oleic acid sodium) is an abundant monounsaturated fatty acid sodium.

  • GC30110 structure
    GC30110Oleic acid (9-cis-Octadecenoic acid)
    CAS: 112-80-1
    Purity: >98.00%

    Oleic acid (9-cis-Octadecenoic acid) is a monounsaturated Omega-9 fatty acid found in plants and animals.

  • GC30535 structure
    GC30535Transdermal Peptide (TD 1 (peptide))
    CAS: 918629-48-8
    Purity: >98%

    Transdermal Peptide (TD 1 (peptide)) is a peptide chaperon with high permeability that facilitates several proteins' transdermal delivery via topical co-administration.

  • GC30927 structure
    GC30927Acevaltrate
    CAS: 25161-41-5
    Purity: >98.00%

    Acevaltrate is an active component extracted from the roots of Valeriana glechomifolia , which inhibits Na + /K + -ATPase in the rat kidney and brain hemispheres with IC 50 s of 22.8μM and 42.3μM.

  • GC32130 structure
    GC32130(+)-SJ733 (SJ000557733)
    CAS: 1424799-20-1
    Purity: >99.00%

    (+)-SJ733 (SJ000557733) is an anti-malaria agent which can also inhibit Na+-ATPase PfATP4.

  • GC34013 structure
    GC34013Digitoxin
    CAS: 71-63-6
    Purity: >99.00%

    Digitoxin is a naturally occurring cardiac glycoside and anti-cancer agent extracted mianly from Digitalis lanata . Digitoxin actively inhibits herpes simplex virus type 1 (HSV-1) replication with a EC 50 value of 0.05M and exhibited the highest cytotoxicity against HeLa cervical cancer cells with an IC 50 value of 28nM at 48h.

  • GC38869 structure
    GC38869Transdermal Peptide TFA
    Purity: >98%
  • GC38903 structure
    GC38903Deslanoside
    CAS: 17598-65-1
    Purity: >98.00%

    Deslanoside is a kind of steroid-like compounds extensively used to treat numerous heart conditions, such as cardiac arrhythmias and hypotension, by primarily inhibiting the Na + /K + -ATPase.

  • GC41514 structure
    GC41514Citreoviridin
    CAS: 25425-12-1
    Purity: >95.00%

    Citreoviridin is a mycotoxin isolated from several Penicillium species that has been shown to inhibit the mitochondrial ATP synthetase system.

  • GC61345 structure
    GC61345Transdermal Peptide Disulfide TFA
    Purity: >98.00%

    Transdermal Peptide Disulfide TFA (TD 1 Disulfide(peptide) TFA) is a 11-amino acid peptide, binds to Na+/K+-ATPase beta-subunit (ATP1B1), and mainly interacts with the C-terminus of ATP1B1.

  • GC61628 structure
    GC61628Neriifolin
    CAS: 466-07-9
    Purity: >96.00%

    Neriifolin, a CNS-penetrating cardiac glycoside, is an inhibitor of the Na+, K+-ATPase.

  • GC63832 structure
    GC63832Strophanthidin
    CAS: 66-28-4
    Purity: >96.00%

    Strophanthidin is a naturally available cardiac glycoside.

  • GC64887 structure
    GC64887Gitoxin
    CAS: 4562-36-1
    Purity: >95.00%

    Gitoxin, a Na+/K+-ATPase inhibitor, usually appears as a result of metabolic degradation of Digitoxin, is just the hydroxyl (ZOH) group close to the C-17β position, which changes the pharmacokinetics and pharmacodynamics of these substances considerably.

  • GC79486 structure
    GC79486Bacoside A (mixture)
    Purity: >98.00%

    Bacoside A (mixture) is a mixture composed of Bacoside A3, Bacopaside II, Bacopaside X and Bacopasaponin C.