Transdermal Peptide (TD 1 (peptide)) |
Catalog No.GC30535
One-Click Copy Product Info
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Transdermal Peptide (TD 1 (peptide)) is a peptide chaperon with high permeability that facilitates several proteins' transdermal delivery via topical co-administration.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 918629-48-8
Sample solution is provided at 25 µL, 10mM.
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Transdermal Peptide (TD 1 (peptide)) is a peptide chaperon with high permeability that facilitates several proteins' transdermal delivery via topical co-administration[1]. Transdermal Peptide binds to Na+/K+-ATPase beta-subunit (ATP1B1), and enhances the transdermal delivery of many macromolecules[2]. Transdermal Peptide temporarily and reversibly modulates the skin barrier by interacting with the lipid matrix and keratin in the stratum corneum, forming transient permeation channels[3]. Transdermal Peptide has been widely coupled with glutathione (GSH) to develop conjugated peptides with high cell membrane permeability and strong transdermal absorption ability in cosmetic products[4].
References:
[1] Ruan R, Wang S, Wang C, et al. Transdermal delivery of human epidermal growth factor facilitated by a peptide chaperon[J]. European journal of medicinal chemistry, 2013, 62: 405-409.
[2] Wang C, Ruan R, Zhang L, et al. Role of the Na+/K+-ATPase beta-subunit in peptide-mediated transdermal drug delivery[J]. Molecular Pharmaceutics, 2015, 12(4): 1259-1267.
[3] Yang G, Li Y, Tian J, et al. From Bioactive Peptides to Transdermal Peptides: An Emerging Strategy for Revolutionizing Drug Delivery[J]. Macromolecular Bioscience, 2026, 26(1): e00485.
[4] Zheng J, Ma Q, Haider A, et al. Improved efficacy of linear glutathione-peptide chaperon complexes on melanogenesis inhibition and transdermal delivery[J]. Bioorganic Chemistry, 2024, 152: 107719.
| Cas No. | 918629-48-8 | SDF | |
| Canonical SMILES | Ala-Cys-Ser-Ser-Ser-Pro-Ser-Lys-His-Cys-Gly | ||
| Formula | C40H66N14O16S2 | M.Wt | 1063.17 |
| Solubility | Soluble in Water | Storage | Store at -20°C |
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 940.6 μL | 4.7029 mL | 9.4058 mL |
| 5 mM | 188.1 μL | 940.6 μL | 1.8812 mL |
| 10 mM | 94.1 μL | 470.3 μL | 940.6 μL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 19 reference(s) in Google Scholar.)