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Annonacin

Catalog No.GC18203

Annonacin is a potent and lipophilic acetogenin from A.

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Annonacin Chemical Structure

Cas No.: 111035-65-5

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1mg
$261.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Description of Annonacin

Annonacin is a potent and lipophilic acetogenin from A. muricata that inhibits mitochondrial complex I (IC50 = 54.8 nM)., Annonacin induces ATP depletion, tau pathologies, and dopaminergic cell death in rats (EC50s = 134, 44.1, and 60.8 nM, respectively). Quantities of annonacin in the fruit and teas made from leaves of A. muricata are such that a cumulative dose sufficient to induce murine neurodegeneration can be attained in humans by regular consumption within one year. This implicates annonacin in the etiology of taupathologies identified in regions of A. muricata consumption. Annonacin also reduces cell survival (ED50 = 0.31 uM in MCF-7 cells) and decreases MCF-7 xenograft tumor size in nude mice at a dose of 50 mg/kg per day.

Chemical Properties of Annonacin

Cas No. 111035-65-5 SDF
Chemical Name 5S-5-methyl-3-[(2R,8R,13R)-2,8,13-trihydroxy-13-[(2R,5R)-tetrahydro-5-[(1R)-1-hydroxytridecyl]-2-furanyl]tridecyl]-2(5H)-furanone
Canonical SMILES O=C1O[C@@H](C)C=C1C[C@H](O)CCCCC[C@@H](O)CCCC[C@@H](O)[C@@]2([H])CC[C@@]([C@H](O)CCCCCCCCCCCC)([H])O2
Formula C35H64O7 M.Wt 596.9
Solubility DMF: 10 mg/ml,DMSO: 20 mg/ml,DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml,Ethanol: 1 mg/ml Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of Annonacin

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1 mg 5 mg 10 mg
1 mM 1.6753 mL 8.3766 mL 16.7532 mL
5 mM 0.3351 mL 1.6753 mL 3.3506 mL
10 mM 0.1675 mL 0.8377 mL 1.6753 mL
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In vivo Formulation Calculator (Clear solution) of Annonacin

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Average Rating: 5 ★★★★★ (Based on Reviews and 26 reference(s) in Google Scholar.)

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