IF 32
Nicotine
Catalog No.: GC14043Purity:>95.00%Synonyms: DL-Nicotine
A nicotinic acetylcholine receptor (nAChR) agonist
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 22083-74-5
10mM (in 1mL DMSO)In Stock
$37.00
1
100mgIn Stock
$114.00
1
250mgIn Stock
$270.00
1
500mgIn Stock
$398.00
1
| Pack Size | Price | Availability | Quantity | Action |
|---|---|---|---|---|
| 10mM (in 1mL DMSO) | $37.00 | In Stock | 1 | |
| 100mg | $114.00 | In Stock | 1 | |
| 250mg | $270.00 | In Stock | 1 | |
| 500mg | $398.00 | In Stock | 1 |
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com
Citations
10 publicationsPublications from researchers using this productDescription
(±)-Nicotine is the racemic mixture of the dominant alkaloid found in tobacco plants. It acts as an agonist at neuronal nicotinic acetylcholine receptors (nAChRs; Kis = 481 and 11.1 nM for α3β4 and α4β2 subtypes, respectively) and possesses addictive and teratogenic properties.1 (−)-(S)-Nicotine is significantly more active at binding nAChRs compared to the (+)-(R) antipode, thus nicotine is typically synthesized as (−)-(S)-nicotine with only 0.2-1% of the (+)-(R) isomer present.2
References
1. Zaveri, N., Jiang, F., Olsen, C., et al. Novel α3β4 nicotinic acetylcholine receptor-selective ligands. Discovery, structure-activity studies, and pharmacological evaluation. J. Med. Chem. 53(22), 8187-8191 (2010).
2. Clayton, P., Lu, A., and Bishop, L. The pyrolysis of (−)-(S)-nicotine: Racemization and decomposition. Chirality 22(4), 442-446 (2010).
Product Documents
Purity:>95.00%Appearance:An oil
Biological Data
1 / 3
Chemical Properties
CAS No.
22083-74-5
Synonyms
DL-Nicotine
Chemical Name
(R)-3-(1-methylpyrrolidin-2-yl)pyridine
SMILES
CN1[C@@H](C2=CC=CN=C2)CCC1
Molecular Formula
C10H14N2
Molecular Weight
162.23
Solubility
30mg/mL in DMSO, 50mg/mL in DMF, 50mg/mL in Ethanol
Storage
Store at -20°C,protect from light
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.
CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility
g/mol
Reviews
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