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Kinsenoside (Synonyms: (+)-Kinsenoside)

Catalog No.GC44006

Kinsenoside is a glycoside originally isolated from A.

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Kinsenoside Chemical Structure

Cas No.: 151870-74-5

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1mg
$52.00
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5mg
$150.00
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10mg
$250.00
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

Kinsenoside is a glycoside originally isolated from A. formosanus that has diverse biological activities, including antihyperlipidemic, immunosuppressive, and anti-inflammatory properties. It increases lipolysis mediated by adipose triglyceride lipase and increases hydrolysis of triglycerides in C3H10T1/2 adipocytes. It also increases phosphorylation of peroxisome proliferator-activated receptor α (PPARα) and CREB as well as protein levels of SIRT1, PGC-1α, and carnitine palmitoyltransferase I. Kinsenoside downregulates the expression and phosphorylation of VEGF receptor 2 (VEGFR2) and inhibits crosstalk between the JAK2/STAT3 and PI3K/AKT signaling pathways in dendritic cells in vitro. It decreases the production of IFN-γ, IL-17, and TNF-α and increases the production of IL-10 in splenocytes isolated from mice with collagen-induced arthritis (CIA). Kinsenoside (300 mg/kg per day) decreases the expression of IL-1β, TNF-α, and matrix metalloproteinase-9 (MMP-9) and increases the expression of IL-10 in inflamed joints in a mouse model of collagen-induced arthritis and prevents paw edema and reduces the severity of arthritis.

Chemical Properties

Cas No. 151870-74-5 SDF
Synonyms (+)-Kinsenoside
Canonical SMILES OC[C@H]1O[C@@H](O[C@]2([H])CC(OC2)=O)[C@H](O)[C@@H](O)[C@@H]1O
Formula C10H16O8 M.Wt 264.2
Solubility DMF: 14 mg/ml,DMSO: 16 mg/ml,PBS (pH 7.2): 10 mg/ml Storage Store at -20°C,protect from light
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 3.785 mL 18.9251 mL 37.8501 mL
5 mM 0.757 mL 3.785 mL 7.57 mL
10 mM 0.3785 mL 1.8925 mL 3.785 mL
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Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

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