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Catalog No.GC18071

CORM-3 is a water-soluble tricarbonyl ruthenium chloride (II) complex, which can release CO rapidly and has anti-inflammatory.

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CORM-3 Chemical Structure

Cas No.: 475473-26-8

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Sample solution is provided at 25 µL, 10mM.

Description Protocol Chemical Properties Product Documents Related Products

CORM-3 is a water soluble CO-releasing molecule, uncouples mitochondrial respiration via interaction with the phosphate carrier. It can reduce the nuclear heterotopic of NF-κB p65, reduce the production of ROS, and increase the levels of glutathione and superoxide dismutase in cells. Besides, CORM-3 reduces the activation of NLRP3 inflammasome [1-3].

CORM-3(0-400 μM; 2 hours) inhibited the effect of H2O2 on the viability of BMSCs in a dose-dependent manner. CORM-3 could reduce reactive oxygen species (ROS) accumulation and prevent mitochondrial dysfunction thereby restoring the osteogenic potential of the BMSCs disrupted by hydrogen peroxide (H2O2) exposure[4]. CORM-3(20 μM ;30 min) induces DNA damage through Ru(II) binding to DNA[5].

CORM-3(4 mg/kg; i.v) mitigated HSR-induced intestinal damages[6]. CORM-3 could effectively improve the inflammatory response induced by activation of the microglia (MG), reduce neuronal apoptosis, promote neural regeneration, and improve the learning and memory performance of mice after radiation[7].


[1]. Long R, Salouage I, Berdeaux A, et,al. CORM-3, a water soluble CO-releasing molecule, uncouples mitochondrial respiration via interaction with the phosphate carrier. Biochim Biophys Acta. 2014 Jan;1837(1):201-9. doi: 10.1016/j.bbabio.2013.10.002. Epub 2013 Oct 23. PMID: 24161358.

[2]. Huang Y, Ma T, et,al. Carbon monoxide (CO) inhibits hydrogen peroxide (H2O2)-induced oxidative stress and the activation of NF-κB signaling in lens epithelial cells. Exp Eye Res. 2018 Jan;166:29-39. doi: 10.1016/j.exer.2017.08.016. Epub 2017 Oct 16. PMID: 29051011.

[3]. Lee DW, Shin HY, et,al. Carbon monoxide regulates glycolysis-dependent NLRP3 inflammasome activation in macrophages. Biochem Biophys Res Commun. 2017 Nov 18;493(2):957-963. doi: 10.1016/j.bbrc.2017.09.111. Epub 2017 Sep 21. PMID: 28942141.

[4]. Jin C, Lin BH, et,al. CORM-3 Attenuates Oxidative Stress-Induced Bone Loss via the Nrf2/HO-1 Pathway. Oxid Med Cell Longev. 2022 Aug 17;2022:5098358. doi: 10.1155/2022/5098358. PMID: 36035220; PMCID: PMC9402314.

[5]. Lyon RF, Southam HM, et,al. CORM-3 induces DNA damage through Ru(II) binding to DNA. Biochem J. 2022 Jul 15;479(13):1429-1439. doi: 10.1042/BCJ20220254. PMID: 35726678; PMCID: PMC9342897.

[6]. Zhang LM, Xin Y, et,al. CORM-3 alleviates the intestinal injury in a rodent model of hemorrhage shock and resuscitation: roles of GFAP-positive glia. J Mol Histol. 2023 Aug;54(4):271-282. doi: 10.1007/s10735-023-10133-w. Epub 2023 Jun 19. PMID: 37335421.

[7]. Lu K, Wu WJ, et,al. CORM-3 Regulates Microglia Activity, Prevents Neuronal Injury, and Improves Memory Function During Radiation-induced Brain Injury. Curr Neurovasc Res. 2020;17(4):464-470. doi: 10.2174/1567202617999200730213259. PMID: 32748746.


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