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CORM-3 Catalog No.GC18071

Exhibits anti-inflammatory/cardioprotective effects

Size Price Stock Qty
20mg
$79.00
In stock
50mg
$156.00
In stock

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Sample solution is provided at 25 µL, 10mM.

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Chemical Properties

Cas No. 475473-26-8 SDF
Synonyms N/A
Chemical Name N/A
Canonical SMILES O=C1[O-][Ru+2]([Cl-])([C]=O)([C]=O)([C]=O)[NH2]C1
Formula C5H4ClNO5Ru M.Wt 294.61
Solubility DMSO : 100 mg/mL; H2O : 50 mg/mL Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
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Background

CORM-3 is a water-soluble carbon monoxide-releasing molecule 1.

As a CO-releasing molecule, CORM-3 can mimic the anti-allergic and anti-anaphylactic effects of heme oxygenase through the activation of the soluble guanylyl cyclase. CORM-3 is reported to have effects on cardiovascular inflammation. It reduces PMN-induced CD54 expression on EC in an in vitro model. CORM-3 also has vasoactive properties in vitro and in vivo. It shows significant vasodilatation through acting as a regulator of vessel tone and blood pressure. Besides that, CORM-3 is also a potent antimicrobial agent. It inhibits the respiration of bacterial and yeast pathogens via increasing membrane permeability and inhibiting the terminal oxidases 1,2,3,4.

References:
1. Vannacci A, Marzocca C, Giannini L, Mazzetti L, Franchi-Micheli S, Failli P, Masini E, Motterlini R, Mannaioni PF. Evaluation of the effects of a novel carbon monoxide releasing molecule (CORM-3) in an in vitro model of cardiovascular inflammation. Inflamm Res. 2006 Apr;55.
2. Clark JE, Naughton P, Shurey S, Green CJ, Johnson TR, Mann BE, Foresti R and Motterlini R. Cardioprotective actions by a water-soluble carbon monoxide-releasing molecule.  Cir. Res. 93:e2-e8, 2003.
3. Foresti R, Hammad J, Clark JE, Johnson TR, Mann BE, Friebe A, Green CJ, Motterlini R. Vasoactive properties of CORM-3, a novel water-soluble carbon monoxide-releasing molecule. Br J Pharmacol. 2004 Jun;142(3):453-60.
4. Wilson JL, Jesse HE, Hughes B, Lund V, Naylor K, Davidge KS, Cook GM, Mann BE, Poole RK. Ru(CO)3Cl(Glycinate) (CORM-3): a carbon monoxide-releasing molecule with broad-spectrum antimicrobial and photosensitive activities against respiration and cation transport in Escherichia coli. Antioxid Redox Signal. 2013 Aug 10;19(5):497-509.