NLRP3-IN-2 |
| Catalog No.GC50569 |
NLRP3 inflammasome inhibitor
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 16673-34-0
Sample solution is provided at 25 µL, 10mM.
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NLRP3 inflammasome inhibitor. Inhibits formation of NLRP3 inflammasome and IL-1β release in LPS and ATP-stimulated mouse macrophages and cardiomyocytes in vitro. Inhibits NLRP3 activation in mouse acute myocardial infarction and peritonitis models without affecting plasma glucose levels. Glyburide synthetic intermediate.
Marchetti et al (2014) A novel pharmacologic inhibitor of the NLRP3 inflammasome limits myocardial injury after ischemia-reperfusion in the mouse. J.Cardiovasc.Pharmacol. 63 316 PMID:24336017 |Fulp et al (2018) Structural insights of benzenesulfonamide analogues as NLRP3 inflammasome inhibitors: design, synthesis, and biological characterization. J.Med.Chem. 61 5412
Average Rating: 5 (Based on Reviews and 24 reference(s) in Google Scholar.)
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