OUL312 |
Catalog No.GC79050
One-Click Copy Product Info
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OUL312 is a potent PARP10 inhibitor ( IC50 = 20 nM), showing more than 75-fold greater selectivity for PARP15 ( IC50 = 1500 nM).
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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In Vitro, OUL312 (Compound 15) (0.05-10 μM, 10-12 days) shows no significant cytotoxicity in HeLa Flp-In TRex cells and could rescue Doxycycline -induced HeLa Flp-In TRex cells in a concentration-dependent manner[1].
References:
[1]. Alaviuhkola J, et al. Optimization of 2,3-dihydrophthalazine-1,4-dione PARP inhibitor scaffold for nanomolar potency and specificity towards human PARP10. Eur J Med Chem. 2025 Dec 15;300:118111.
| Cas No. | SDF | ||
| Formula | C16H13FN2O3 | M.Wt | 300.28 |
| Solubility | DMSO: 10 mg/mL (33.30 mM; Need ultrasonic and warming) | Storage | Store at -20°C |
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.3302 mL | 16.6511 mL | 33.3023 mL |
| 5 mM | 666 μL | 3.3302 mL | 6.6605 mL |
| 10 mM | 333 μL | 1.6651 mL | 3.3302 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)