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PARP

Poly (ADP-ribose) polymerases (PARPs) is a large family of proteins with a conserved catalytic domain that catalyze an immediate DNA-damage-dependent post-translational modification of histones and other nuclear proteins leading to the survival of injured proliferating cells. So far, a total number of 18 human PARP proteins encoded by different genes have been identified, including PARP-1 to PARP-4, PARP-5a, PARP-5b, PARP-5c and PARP-6 to PARP-16. The general structural of PARP proteins has been revealed through the extensive study of the founding family member PARP-1, which is characterized by the presence of four functional domains, including a DNA-binding domain, a caspase-cleaved domain, an automodification domain and a catalytic domain.

Products for  PARP

  1. Cat.No. Product Name Information
  2. GC11761 4-amino-1,8-Naphthalimide PARP inhibitor 4-amino-1,8-Naphthalimide  Chemical Structure
  3. GC16474 4-HQN PARP inhibitor 4-HQN  Chemical Structure
  4. GN10629 5,7-dihydroxychromone Nrf2/ARE signal activator and PPARγ agonist 5,7-dihydroxychromone  Chemical Structure
  5. GC12390 A-966492 PARP-1/-2 inhibitor, highly potent A-966492  Chemical Structure
  6. GC12422 ABT-888 (Veliparib) A potent PARP inhibitor ABT-888 (Veliparib)  Chemical Structure
  7. GC16318 AG-14361 Potent PARP1 inhibitor AG-14361  Chemical Structure
  8. GC16725 AZ6102 TNKS1/2 inhibitor AZ6102  Chemical Structure
  9. GC17965 AZD2461 Novel PARP inhibitor AZD2461  Chemical Structure
  10. GC12844 Benzamide poly (ADP-ribose) synthetase inhibitor Benzamide  Chemical Structure
  11. GC14380 BGP-15 PARP inhibitor BGP-15  Chemical Structure
  12. GC15932 BMN 673 Potent PARP inhibitor BMN 673  Chemical Structure
  13. GC10920 BMN-673 8R,9S PARP inhibitor BMN-673 8R,9S  Chemical Structure
  14. GC33223 BRCA1-IN-1 BRCA1-IN-1  Chemical Structure
  15. GC10690 BYK 204165 PARP-1 inhibitor,potent and selective BYK 204165  Chemical Structure
  16. GC14434 BYK 49187 Potent PARP-1/PARP-2 inhibitor BYK 49187  Chemical Structure
  17. GN10040 Dehydrocorydaline Extracted from Corydalis yanhusuo W.T. Wang dried rhizome;Store the product in sealed, cool and dry condition Dehydrocorydaline  Chemical Structure
  18. GC12680 DR 2313 PARP inhibitor DR 2313  Chemical Structure
  19. GC64209 E7016 E7016  Chemical Structure
  20. GC18172 E7449 E7449 is an inhibitor of poly(ADP-ribose) polymerase 1 (PARP1) and PARP2 (IC50s = 1 and 1.2 nM, respectively) as well as tankyrase (TNKS) 1/2 (IC50s = 50-100 nM). E7449  Chemical Structure
  21. GC12991 EB 47 Potent PARP-1 inhibitor EB 47  Chemical Structure
  22. GC38167 Fucosterol Fucosterol  Chemical Structure
  23. GC13541 G007-LK tankyrase 1/2 inhibitor G007-LK  Chemical Structure
  24. GC19542 GeA-69

    GeA-69 is a selective, highly cell permeable allosteric inhibitor

    GeA-69   Chemical Structure
  25. GC15353 Iniparib (BSI-201)

    PARP1 inhibitor,intravenously adminsitered

    Iniparib (BSI-201)  Chemical Structure
  26. GC38385 INO-1001 INO-1001  Chemical Structure
  27. GC12496 INO-1001 Potent PARP inhibitor INO-1001  Chemical Structure
  28. GC12869 JW 55 PARP domain inhibitor JW 55  Chemical Structure
  29. GC34195 K-756 K-756  Chemical Structure
  30. GC13419 ME0328 PARP inhibitor,potent and selective ME0328  Chemical Structure
  31. GC17802 MK-4827 PARP-1/-2 inhibitor,potent and selective MK-4827  Chemical Structure
  32. GC12756 MK-4827 hydrochloride

    PARP1/PARP2 inhibitor

    MK-4827 hydrochloride  Chemical Structure
  33. GC11537 MK-4827 tosylate

    PARP1/PARP2 inhibitor

    MK-4827 tosylate  Chemical Structure
  34. GC16914 MN 64 tankyrase inhibitor MN 64  Chemical Structure
  35. GC34120 Niraparib R-enantiomer (MK 4827 (R-enantiomer)) Niraparib R-enantiomer (MK 4827 (R-enantiomer))  Chemical Structure
  36. GC19264 NMS-P118 NMS-P118 is a potent, orally available, and highly selective PARP-1 Inhibitor for cancer therapy. NMS-P118  Chemical Structure
  37. GC17775 NU 1025 PARP inhibitor,potent and novel NU 1025  Chemical Structure
  38. GC17555 NVP-TNKS656 TNKS2 inhibitor NVP-TNKS656  Chemical Structure
  39. GC17580 Olaparib (AZD2281, Ku-0059436) A potent PARP1/PARP2 inhibitor Olaparib (AZD2281, Ku-0059436)  Chemical Structure
  40. GN10114 Oroxin A Extracted from Oroxylum indicum;Store the product in sealed, cool and dry condition Oroxin A  Chemical Structure
  41. GC34071 Pamiparib (BGB-290)

    An orally active, potent, highly selective PARP inhibitor

    Pamiparib (BGB-290)  Chemical Structure
  42. GC14251 Picolinamide poly (ADP-ribose) synthetase inhibitor Picolinamide  Chemical Structure
  43. GC10995 PJ34 PARP-l inhibitor PJ34  Chemical Structure
  44. GC10145 PJ34 hydrochloride

    PARP inhibitor,potent and cell-permeable

    PJ34 hydrochloride  Chemical Structure
  45. GC19505 RK-287107

    RK-287107 is a potent and specific tankyrase inhibitor with IC50s of 14.3 and 10.6 nM for tankyrase-1 and tankyrase-2, respectively

    RK-287107   Chemical Structure
  46. GC15955 Rucaparib (AG-014699,PF-01367338)

    Potent PARP inhibitor

    Rucaparib (AG-014699,PF-01367338)  Chemical Structure
  47. GC13249 Rucaparib (free base)

    Potent PARP inhibitor

    Rucaparib (free base)  Chemical Structure
  48. GC32793 Rucaparib Camsylate Rucaparib Camsylate  Chemical Structure
  49. GC37728 Talazoparib tosylate Talazoparib tosylate  Chemical Structure
  50. GC15041 Tankyrase Inhibitors (TNKS) 22 Tankyrase inhibitor Tankyrase Inhibitors (TNKS) 22  Chemical Structure
  51. GC11548 Tankyrase Inhibitors (TNKS) 49 Tankyrase inhibitor Tankyrase Inhibitors (TNKS) 49  Chemical Structure
  52. GC14509 UPF 1069

    Selective PARP2 inhibitor

    UPF 1069  Chemical Structure
  53. GC17783 Veliparib dihydrochloride PARP-1/PARP-2 inhibitor Veliparib dihydrochloride  Chemical Structure
  54. GC33358 WD2000-012547 WD2000-012547  Chemical Structure
  55. GC11674 WIKI4 Inhibitor of Wnt/ß-Catenin signaling and tankyrase WIKI4  Chemical Structure
  56. GC12781 XAV-939 Tankyrase 1/2 inhibitor XAV-939  Chemical Structure

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