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Poly (ADP-ribose) polymerases (PARPs) is a large family of proteins with a conserved catalytic domain that catalyze an immediate DNA-damage-dependent post-translational modification of histones and other nuclear proteins leading to the survival of injured proliferating cells. So far, a total number of 18 human PARP proteins encoded by different genes have been identified, including PARP-1 to PARP-4, PARP-5a, PARP-5b, PARP-5c and PARP-6 to PARP-16. The general structural of PARP proteins has been revealed through the extensive study of the founding family member PARP-1, which is characterized by the presence of four functional domains, including a DNA-binding domain, a caspase-cleaved domain, an automodification domain and a catalytic domain.

  1. Cat.No. Product Name Information
  2. GC11761 4-amino-1,8-Naphthalimide PARP inhibitor
  3. GC16474 4-HQN PARP inhibitor
  4. GN10629 5,7-dihydroxychromone Nrf2/ARE signal activator and PPARγ agonist
  5. GC12390 A-966492 PARP-1/-2 inhibitor, highly potent
  6. GC12422 ABT-888 (Veliparib)

    Potent PARP inhibitor

  7. GC16318 AG-14361 Potent PARP1 inhibitor
  8. GC16725 AZ6102 TNKS1/2 inhibitor
  9. GC17965 AZD2461 Novel PARP inhibitor
  10. GC12844 Benzamide poly (ADP-ribose) synthetase inhibitor
  11. GC14380 BGP-15 PARP inhibitor
  12. GC15932 BMN 673 Potent PARP inhibitor
  13. GC10920 BMN-673 8R,9S PARP inhibitor
  14. GC33223 BRCA1-IN-1
  15. GC10690 BYK 204165 PARP-1 inhibitor,potent and selective
  16. GC14434 BYK 49187 Potent PARP-1/PARP-2 inhibitor
  17. GN10040 Dehydrocorydaline Extracted from Corydalis yanhusuo W.T. Wang dried rhizome;Store the product in sealed, cool and dry condition
  18. GC12680 DR 2313 PARP inhibitor
  19. GC18172 E7449 E7449 is an inhibitor of poly(ADP-ribose) polymerase 1 (PARP1) and PARP2 (IC50s = 1 and 1.2 nM, respectively) as well as tankyrase (TNKS) 1/2 (IC50s = 50-100 nM).
  20. GC12991 EB 47 Potent PARP-1 inhibitor
  21. GC38167 Fucosterol

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