Oxoadipic acid is a metabolite of the essential amino acids tryptophan and lysine, playing an important role in the tryptophan metabolism and lysine degradation pathways[1-2]. Oxoadipic acid is elevated in responders to rheumatoid arthritis treatment and can serve as a biomarker in metabolomics prediction models[3-4].
References:
[1] Qu Q, Chen Y, Wang Y, et al. Lithocholic acid phenocopies anti-ageing effects of calorie restriction. Nature. 2025 Jul;643(8070):192-200.
[2] Shibata K, Yasui M, Sano M, Fukuwatari T. Fluorometric determination of 2-oxoadipic acid, a common metabolite of tryptophan and lysine, by high-performance liquid chromatography with pre-chemical derivatization. Biosci Biotechnol Biochem. 2011;75(1):185-7.
[3] Schulze-Bergkamen A, Okun JG, Spiekerkötter U, et al. Quantitative acylcarnitine profiling in peripheral blood mononuclear cells using in vitro loading with palmitic and 2-oxoadipic acids: biochemical confirmation of fatty acid oxidation and organic acid disorders. Pediatr Res. 2005 Nov;58(5):873-80.
[4] Jian C, Zhu J, Wu J, et al. Multiomics Analyses Reveal an Essential Role of Tryptophan in Treatment of csDMARDs in Rheumatoid Arthritis. Adv Sci (Weinh). 2025 Sep 23:e13170.