Oxoadipic acid (Synonyms: α-Ketoadipate, 2-Ketoadipic Acid, α-Ketoadipic Acid, α-Oxoadipic Acid) |
Catalog No.GC30654
One-Click Copy Product Info
|
Oxoadipic acid is a metabolite of the essential amino acids tryptophan and lysine, playing an important role in the tryptophan metabolism and lysine degradation pathways.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 3184-35-8
Sample solution is provided at 25 µL, 10mM.
_1-3.$$$39978408@51.jpg');)
_1-9.$$$38538795@65.jpg');)
_1-9.$$$39112701@51.jpg');)
_1-7.$$$37316672@70.jpg');)
_366-372.$$$36198801@70.jpg');)
.$$$38565142@65.jpg');)
_1867-1883.$$$33248023@67.jpg');)
_eads6055.$$$39977546@45.jpg');)
_eadm9805.$$$40080571@45.jpg');)
_eadj3020.$$$39666821@45.jpg');)
_1-20.$$$39757301@28.jpg');)
_1-24.$$$38898113@28.jpg');)
_273-287.$$$36806353@46.jpg');)
_1-16.$$$37156877@44.jpg');)
_1-19.$$$37460805@44.jpg');)
_1291-1307.$$$34518654@46.jpg');)
Oxoadipic acid is a metabolite of the essential amino acids tryptophan and lysine, playing an important role in the tryptophan metabolism and lysine degradation pathways[1-2]. Oxoadipic acid is elevated in responders to rheumatoid arthritis treatment and can serve as a biomarker in metabolomics prediction models[3-4].
References:
[1] Qu Q, Chen Y, Wang Y, et al. Lithocholic acid phenocopies anti-ageing effects of calorie restriction. Nature. 2025 Jul;643(8070):192-200.
[2] Shibata K, Yasui M, Sano M, Fukuwatari T. Fluorometric determination of 2-oxoadipic acid, a common metabolite of tryptophan and lysine, by high-performance liquid chromatography with pre-chemical derivatization. Biosci Biotechnol Biochem. 2011;75(1):185-7.
[3] Schulze-Bergkamen A, Okun JG, Spiekerkötter U, et al. Quantitative acylcarnitine profiling in peripheral blood mononuclear cells using in vitro loading with palmitic and 2-oxoadipic acids: biochemical confirmation of fatty acid oxidation and organic acid disorders. Pediatr Res. 2005 Nov;58(5):873-80.
[4] Jian C, Zhu J, Wu J, et al. Multiomics Analyses Reveal an Essential Role of Tryptophan in Treatment of csDMARDs in Rheumatoid Arthritis. Adv Sci (Weinh). 2025 Sep 23:e13170.
| Cas No. | 3184-35-8 | SDF | |
| Synonyms | α-Ketoadipate, 2-Ketoadipic Acid, α-Ketoadipic Acid, α-Oxoadipic Acid | ||
| Canonical SMILES | O=C(O)C(CCCC(O)=O)=O | ||
| Formula | C6H8O5 | M.Wt | 160.12 |
| Solubility | Soluble in DMSO | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 6.2453 mL | 31.2266 mL | 62.4532 mL |
| 5 mM | 1.2491 mL | 6.2453 mL | 12.4906 mL |
| 10 mM | 624.5 μL | 3.1227 mL | 6.2453 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >97.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 9 reference(s) in Google Scholar.)