GSK121 (trifluoroacetate salt) |
| Catalog No.GC43788 |
GSK-121 Trifluoroacetates a selective PAD4 inhibitor.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1652591-80-4
Sample solution is provided at 25 µL, 10mM.
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Protein arginine deiminase 4 (PAD4) mediates the transformation of protein arginine into citrulline. Citrullination of proteins has normal roles in gene regulation and pathological roles in immunological and inflammatory diseases. GSK121 is the initial compound identified in a screen for PAD4 inhibitors and was optimized to produce the more potent PAD4 inhibitors, GSK484 and GSK199 . GSK121 was shown to inhibit the citrullination of PAD4 target proteins in a functional assay with an IC50 value of 3.2 µM.
Average Rating: 5 (Based on Reviews and 16 reference(s) in Google Scholar.)
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