Pro-Oxidant Activity

A neuropeptide with diverse biological activities

6α-hydroxy Cholesterol is an oxysterol that increases superoxide anion production in SK-N-BE cells when used at concentrations of 50 and 100 μM.

4-hydroxy Alternariol is a metabolite of the mycotoxin alternariol formed through cytochrome P450 (CYP450) metabolism.

AAPH is a water-soluble azo compound

Ermanin is a flavonoid isolated from Tanacetum microphyllum.

Methylprednisolone acetate, a prednisolone derivative, is a corticosteroid?hormone.

SRS11-92 is a ferroptosis inhibitor and a derivative of ferrostatin-1.

10-methyl-9-(phenoxycarbonyl) Acridinium is an acridinium ester that produces fluorescent 10-methyl-9-acridone upon oxidation with hydrogen peroxide, persulfates, and other oxidants in alkaline conditions.

1-Palmitoyl-2-hydroxy-sn-glycero-3-PC is an abundant gonadal LPC (lysophosphatidylcholine).

Xanthine oxidase (XO) generates reactive oxygen species, including hydrogen peroxide (H2O2), as it oxidizes specific substrates in the presence of water and oxygen.

9,10-Anthracenediyl-bis(methylene)dimalonic Acid is a water soluble derivative of anthracene and is usaually applied as singlet-oxygen probe. 9,10-Anthracenediyl-bis(methylene)dimalonic Acid can be photobleached by singlet oxygen to its corresponding endoperoxide, causing a time-dependent decrease in absorbance at 380-400nm.

Cancer cell survival appears partly dependent on antioxidative enzymes, whose expression is regulated by the Keap1-Nrf2 pathway, to quench potentially toxic reactive oxygen species generated by their metastatic transformation.

Erastin2 is a potent system xc- inhibitor and ferroptosis-inducing agent.

L-Selenocystine is an oxidation diselenide product of selenocysteine with strong antioxidant activity.

MGR2 is a negative control compound for the activity of the reactive oxygen species-generating probe MGR1.

Formed in vivo by the reaction of NO with superoxide

Superoxide radical anion is a toxic by-product of mitochondrial respiration that is formed from approximately 1-4% of the oxygen metabolized by aerobic organisms.

Tetrachlorohydroquinone (TCHQ) is a metabolite of the organochlorine biocide pentachlorophenol.

Urotensin II is a somatostatin-like neuropeptide agonist of the urotensin II receptor (UTR; Ki = 2 nM).

β-BHC is an isomer of the organochlorine pesticide γ-lindane that is a potential impurity found in commercial preparations of lindane.

A trichothecene mycotoxin