KEAP1-Nrf2

A phenolic acid with anti-inflammatory activity

Danshensu (Dan shen suan A) is an orally active compound and one of the major active constituents of the traditional Chinese medicine Salvia miltiorrhiza (Danshen).

TBHQ(tert-Butylhydroquinone) is a powerful phenolic antioxidant capable of reducing oxidative stress and inflammatory reactions.

Brusatol is an Nrf2 inhibitor isolated from Brucea javanica and exhibits significant tumor inhibition in multiple cancers through decreased resistance to cancer oxidative stress injury.

KI696 isomer is the less active isomer of KI696.

CDDO-dhTFEA (RTA dh404) is a synthetic oleanane triterpenoid compound which potently activates Nrf2 and inhibits the pro-inflammatory transcription factor NF-κB.

CDDO-EA is an NF-E2 related factor 2/antioxidant response element (Nrf2/ARE) activator.

Keap1-Nrf2-IN-1 is a Keap1 (Kelch-like ECH-associated protein 1)-Nrf2 (nuclear factor erythroid 2-related factor 2) protein-protein interaction inhibitor, and with an IC50 of 43 nM for Keap1 protein.

Nrf2-IN-1 is an inhibitor of nuclear factor-erythroid 2-related factor 2 (Nrf2), which is developed for the research of acute myeloid leukemia (AML).

ML334 is a potent, cell-permeable activator of NRF2.

Curcumin-d6 is intended for use as an internal standard for the quantification of curcumin by GC- or LC-MS.

L-Sulforaphane is an orally active, non-specific activator of nuclear factor erythroid 2-related factor 2 (Nrf2), which functions by inhibiting the interaction between Keap1 protein and Nrf2.

Kinsenoside is a bioactive glycoside extracted from Anoectochilus roxburghii .

Nrf2 activator; inhibits Nrf2/Keap1 interaction

Ezetimibe ketone (EZM-K) is a phase-I metabolite of Ezetimibe.

Safranal is a novel, orally active monoterpene aldehyde and the main active component of saffron .

Toralactone, isolated from Cassia obtusifolia, mediates hepatoprotection via an Nrf2-dependent anti-oxidative mechanism.

Dibenzoylmethane, a minor ingredient in licorice, activates Nrf2 and prevents various cancers and oxidative damage.

CBR-470-2, a glycine-substituted analog, can activate NRF2 signaling.

Bakkenolide B is a sesquiterpene lactone compound isolated from the leaves of Petaites japonicas , possessing anti-allergic and anti-inflammatory effects.

Dimethyl fumarate D6 is a deuterium labeled Dimethyl fumarate.

Eriodictyol-7-O-glucoside (Eriodictyol 7-O-β-D-glucoside), a flavonoid, is a potent free radical scavenger.

S-Allylmercaptocysteine is a water-soluble organic sulfur compound derived from garlic extract. S-Allylmercaptocysteine has anti-tumor, antioxidant, anti-inflammatory and tissue-protective effects, and can exert biological activity by regulating ROS/MAPK, Nrf2, NF-κB and apoptosis-related signaling pathways.

DDO-7263, a 1,2,4-Oxadiazole derivative, is a potent Nrf2-ARE activator.