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KEAP1-Nrf2

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The KEAP1-Nrf2 pathway is the major regulator of cytoprotective responses to chemical and/or oxidative stresses caused by reactive oxygen species (ROS) and electrophiles. Nrf2 (nuclear factor erythroid 2-related factor 2) is a transcription factor that binds together with small Maf proteins to the antioxidant response element (ARE) in the regulatory regions of cellular defense enzyme genes leading to the activation of a wide rang of cell defense processes; while KEAP1 (Kelch ECH associating protein 1), a negative repressor of Nrf2, is an adaptor protein for a Cul3-based ubiqutitin E3 ligase that binds to Nrf2 and promotes its degradation by the ubiquitin proteasome pathway.

Products Related to KEAP1-Nrf2(81)

  • GC65610 structure
    GC65610(R)-5-Hydroxy-1,7-diphenyl-3-heptanone
    CAS: 100761-20-4
    Purity: >99.00%

    (R)-5-Hydroxy-1,7-diphenyl-3-heptanone is a diarylheptanoid that can be found in Alpinia officinarum.

  • GC66004 structure
    GC66004K67
    CAS: 2046250-48-8
    Purity: >98%

    K67 specifically inhibits the interaction between Keap1 and S349-phosphorylated p62. K67 prevents p-p62 from blocking the binding of Keap1 and Nrf2. K67 effectively inhibits the proliferation of HCC cultures with high cellular S351-phosphorylated p62 by restoring the ubiquitination and degradation of Nrf2 driven by Keap1.

  • GC66054 structure
    GC66054Nrf2 activator-4
    CAS: 2383016-68-8
    Purity: >98.00%

    Nrf2 activator-4 (Compound 20a) is a highly potent, orally active Nrf2 activator with an EC50 of 0.63 μM. Nrf2 activator-4 suppresses reactive oxygen species against oxidative stress in microglia. Nrf2 activator-4 effectively recovers the learning and memory impairment in a scopolamine-induced mouse model.

  • GC66354 structure
    GC66354Ezetimibe-d4-1
    CAS: 1093659-89-2
    Purity: >98%

    Ezetimibe-d4 is deuterium labeled Ezetimibe. Ezetimibe (SCH 58235) is a potent cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator.

  • GC69590 structure
    GC69590Nrf2 activator-2
    CAS: 2770448-53-6
    Purity: >98.00%

    Nrf2 activator-2 (compound O15) is a derivative of sulforaphane, an effective Nrf2 activator with an EC50 of 2.9 μM in 293 T cells. Nrf2 activator-2 effectively inhibits the interaction between Keap1 and Nrf2, thereby showing an activating effect on Nrf2. Nrf2 activator-2 significantly reduces the level of ubiquitinated Nrf2 in cells.

  • GC70411 structure
    GC70411Nrf2-Activator-12G
    CAS: 1554271-18-9
    Purity: >99.00%

    Nrf2-Activator-12G (compd 12g) is an activator of Nrf2.

  • GC70520 structure
    GC70520MIND4-17
    CAS: 345989-24-4
    Purity: >99.00%

    MIND4-17 is a potent NRF2 activator that covalently modifies a C151 residue of Keap1.

  • GC70868 structure
    GC70868Nrf2 activator-3
    CAS: 2766570-23-2
    Purity: >98.00%

    Nrf2 activator-3 is a potent Nrf2 activator.

  • GC71031 structure
    GC71031Nrf2 activator-6
    CAS: 2728780-74-1

    Nrf2 activator-6, a tetrahydroisoquinoline compound, is a Nrf2 activator.

  • GC71072 structure
    GC71072NXPZ-2
    CAS: 2254492-08-3
    Purity: >98.00%

    NXPZ-2 is an orally active Keap1-Nrf2 protein–protein interaction (PPI) inhibitor with a Ki value of 95 nM, EC50 value of 120 and 170 nM.

  • GC71232 structure
    GC71232I-152
    CAS: 311343-11-0
    Purity: >98.00%

    I-152 is a conjugate containing N-acetyl-cysteine (NAC) and cysteamine (MEA).

  • GC71544 structure
    GC71544Antroquinonol
    CAS: 1010081-09-0
    Purity: >98.00%

    Antroquinonol ((+)-Antroquinonol), a ubiquinone derivative from the mushroom Antrodia camphorata, has hepatoprotective, anti-inflammatory, and anti-cancer effects.

  • GC73243 structure
    GC73243Nrf2-IN-3
    CAS: 6325-13-9
    Purity: >99.00%

    Nrf2-IN-3 (Compound R16) is a Nrf2 inhibitor.

  • GC74090 structure
    GC74090Dimethyl fumarate-d2
    CAS: 23057-98-9
    Purity: >99.00%

    Dimetl fumarate-d2 is the deuterium labeled Dimetl fumarate.

  • GC79725 structure
    GC79725DI-1548
    CAS: 2247060-97-3
    Purity: >98%

    DI-1548 is a potent, selective, and irreversible covalent inhibitor of DCN1 ( IC 50 = 4.6 nM).

  • GC79814 structure
    GC79814Isosorbide di-(methyl fumarate)
    CAS: 2013542-44-2
    Purity: >99.50%

    Isosorbide di-(methyl fumarate) (IDMF), topical DMF derivative, is an NRF2/ARE pathway activator.

  • GC80416 structure
    GC80416Omaveloxolone-d 3
    Purity: >98%

    Omaveloxolone -d 3 (RTA 408-d 3 ) is the deuterated-labeled Omaveloxolone.

  • GC80873 structure
    GC80873Tovophyllin A
    CAS: 40738-44-1
    Purity: >98%

    Tovophyllin A is an orally active xanthonoid compound.

  • GC81040 structure
    GC81040VVD 065
    CAS: 3034876-85-9
    Purity: >99.50%

    VVD 065 is an orally active KEAP1 -dependent NRF2 molecular glue degrader with a KEAP1 K D of 65 nM.

  • GC81605 structure
    GC81605PGK1-IN-1
    CAS: 3093312-81-0
    Purity: >99.50%

    PGK1-IN-1 (Compound 6e) is a potent and selective PGK1 inhibitor ( IC 50 : 33 nM).

  • GC81611 structure
    GC81611Nrf2-IN-4 hydrobromide
    Purity: >99.00%

    Nrf2-IN-4 (Compound PhcY) hydrobromide is a Nrf2 inhibitor.

  • GF11023 structure
    GF11023Hecubine
    CAS: 62874-52-6
    Purity: >98.00%

    Hecubine is a natural aspidosperma-type alkaloid found in E. officinalis , with anti-neuroinflammation properties.

  • GN10038 structure
    GN10038Ginsenoside Rh3
    CAS: 105558-26-7
    Purity: >99.50%
  • GN10318 structure
    GN10318Danshensu
    CAS: 22681-72-7
    Purity: >98.00%