p53
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The p53 tumor suppressor is a 53 kDa nuclear phosphoprotein of 393 amino acids that is encoded by the TP53 gene (20 kb with 11 exons and 10 introns) and characterized by the presence of several structural and functional domains, including a N-terminus, a central core domain, a C-terminal region, a strongly basic carboxyl-terminal regulatory domain, a nuclear localization signal sequence and three nuclear export signal sequence. The p53 is considered as a major “guardian of genome” for its activities in a wide range of cellular events, including cell-cycle regulation, induction of apoptosis, gene amplification, DNA recombination, chromosomal segregation and cellular senescence.
Products Related to p53(152)
- GC73719BAY 1892005CAS: 2036352-13-1Purity: >99.00%
BAY 1892005 is a regulator of p53 protein and acts on p53 condensates without causing mutant p53 reactivation.
- GC73823MMs02943764CAS: 708287-29-0Purity: >98.00%
MMs02943764 is a 1,2,4-triazole derivative with anticancer activity.
- GC73918BAY 249716CAS: 696628-24-7Purity: >99.00%
BAY 249716 stabilizes all three p53 protein variants.
- GC74256Condurango glycoside ACAS: 11051-90-4Purity: >95.00%
Condurango glycoside A is an activator of p53.
- GC74358PNC-27 acetatePurity: >99.00%
PNC-27 acetate, a chimeric p53-penetratin peptide binds to HDM-2 in a p53 peptide-like structure, induces selective membrane-pore formation and leads to cancer cell lysis.
- GC78972MI-773 TFACAS: 1303609-37-1Purity: >98.50%
MI-773 TFA is an orally active, selective MDM2-p53 interaction inhibitor with a K i of 0.88 nM for MDM2.
- GC78973Peptide 234CM TFAPurity: >98.00%
Peptide 234CM TFA is a peptide containing isoleucine at position 3, corresponding to the sequence of a point mutation in p53 codon 234.
- GC78974p53 (17-26) acetatePurity: >98.00%
p53 (17-26) acetate is a peptide derived from the P53 MDM2 binding domain, with a K d of 50 nM for MDM2.
- GC78980Rhodojaponin VICAS: 37720-87-9Purity: >99.50%
Rhodojaponin VI is an orally active diterpenoid compound found in hododendron molle G.
- GC79004PMV6-PEG4-BI2536Purity: >98.00%
PMV6-PEG4-BI2536 is an RIPTAC-like bifunctional molecule that promotes the formation of the p53 Y 220C -PLK1 ternary complex ( EC 50 = 1.4 μM).
- GC79976Chitosan oligosaccharide (MW 2000)Purity: >98.00%
Chitosan oligosaccharide (MW 2000) is a natural oligomer derived from chitosan, with a molecular weight of 2000 Da.
- GC80853(4R,5S)-YX-02-030CAS: 3049077-01-9Purity: >99.50%
(4R,5S)-YX-02-030 is an isomer of YX-02-030.
- GC80881PROTAC DAPK1 Degrader-1CAS: 3063030-38-3Purity: >96.50%
PROTAC DAPK1 Degrader-1 is a death-associated protein kinase 1 (DAPK1) degrader with a DC 50 of 119.6 nM.
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GC73604 | MeOIstPyrd | 2308548-54-9 | >99.00% | |
MeOIstPyrd is an anti-skin cancer agent. | ||||
| GC73719 | BAY 1892005 | 2036352-13-1 | >99.00% | |
BAY 1892005 is a regulator of p53 protein and acts on p53 condensates without causing mutant p53 reactivation. | ||||
| GC73823 | MMs02943764 | 708287-29-0 | >98.00% | |
MMs02943764 is a 1,2,4-triazole derivative with anticancer activity. | ||||
| GC73918 | BAY 249716 | 696628-24-7 | >99.00% | |
BAY 249716 stabilizes all three p53 protein variants. | ||||
| GC73939 | ATPase-IN-3 | 1134203-12-5 | >99.00% | |
ATPase-IN-3 (compound 6) is a ATPase inhibitor. | ||||
| GC74256 | Condurango glycoside A | 11051-90-4 | >95.00% | |
Condurango glycoside A is an activator of p53. | ||||
| GC74358 | PNC-27 acetate | - | >99.00% | |
PNC-27 acetate, a chimeric p53-penetratin peptide binds to HDM-2 in a p53 peptide-like structure, induces selective membrane-pore formation and leads to cancer cell lysis. | ||||
| GC78809 | UCI-14 | 301312-49-2 | >98.00% | |
UCI-14 is a gltA1/lprQ modulator with in vitro anti-tuberculosis activity against drug-sensitive and multidrug-resistant mycobacteria. | ||||
| GC78961 | GPS167 | 3034312-19-8 | >98.00% | |
GPS167 is a CLK kinase inhibitor that potently and selectively inhibits recombinant human CLK1, CLK2 and CLK4. | ||||
| GC78970 | UCI-LC0019 | 1372406-51-3 | >98.50% | |
UCI-LC0019 is a mutant p53 reactivator. | ||||
| GC78971 | UCI-1014 | 304896-41-1 | >98.00% | |
UCI-1014 is a mutant p53 ( p53 R175H ) corrector/reactivator. | ||||
| GC78972 | MI-773 TFA | 1303609-37-1 | >98.50% | |
MI-773 TFA is an orally active, selective MDM2-p53 interaction inhibitor with a K i of 0.88 nM for MDM2. | ||||
| GC78973 | Peptide 234CM TFA | - | >98.00% | |
Peptide 234CM TFA is a peptide containing isoleucine at position 3, corresponding to the sequence of a point mutation in p53 codon 234. | ||||
| GC78974 | p53 (17-26) acetate | - | >98.00% | |
p53 (17-26) acetate is a peptide derived from the P53 MDM2 binding domain, with a K d of 50 nM for MDM2. | ||||
| GC78980 | Rhodojaponin VI | 37720-87-9 | >99.50% | |
Rhodojaponin VI is an orally active diterpenoid compound found in hododendron molle G. | ||||
| GC79004 | PMV6-PEG4-BI2536 | - | >98.00% | |
PMV6-PEG4-BI2536 is an RIPTAC-like bifunctional molecule that promotes the formation of the p53 Y 220C -PLK1 ternary complex ( EC 50 = 1.4 μM). | ||||
| GC79049 | CG-1521 | 674767-29-4 | >95.50% | |
CG-1521 is a histone deacetylase ( HDAC ) inhibitor that stabilizes Ac-Lys373 P53, increases P21 levels and HDAC2 degradation. | ||||
| GC79111 | CK2-TN03 | 313226-24-3 | >98.00% | |
CK2-TN03 is an ATP-competitive casein kinase 2 ( CK2 ) inhibitor, with an IC 50 of 165 nM and a K i of 20 nM. | ||||
| GC79144 | MC3817 free base | - | >98.00% | |
MC3817 free base is a selective DNMT1 inhibitor. | ||||
| GC79145 | MC3817 | - | >99.50% | |
MC3817 is a selective DNMT1 inhibitor. | ||||
| GC79146 | Ischemin | 1357059-00-7 | >99.50% | |
Ischemin is a CBP bromodomain inhibitor that inhibits p53 interaction with CBP and transcriptional activity in cells. | ||||
| GC79976 | Chitosan oligosaccharide (MW 2000) | - | >98.00% | |
Chitosan oligosaccharide (MW 2000) is a natural oligomer derived from chitosan, with a molecular weight of 2000 Da. | ||||
| GC80853 | (4R,5S)-YX-02-030 | 3049077-01-9 | >99.50% | |
(4R,5S)-YX-02-030 is an isomer of YX-02-030. | ||||
| GC80881 | PROTAC DAPK1 Degrader-1 | 3063030-38-3 | >96.50% | |
PROTAC DAPK1 Degrader-1 is a death-associated protein kinase 1 (DAPK1) degrader with a DC 50 of 119.6 nM. | ||||