p53

RITA (NSC 652287) is a tricyclic thiophene derivative that binds to p53dN (K d =1.5nM) and blocks the p53-HDM-2 interaction, thereby inhibiting p53 ubiquitination.

MIRA-1 is a maleimide-type compound with the ability to restore wild type conformation and function to mutant p53.

An inhibitor of the MDM2-p53 interaction

A small molecule inhibitor of MDMX

A small molecule activator of p53

CBL0137 is a first-in-class small molecule compound that targets the FACT complex to modulate chromatin structure and gene expression. It can inhibit the activity of the NF-κB signaling pathway and has anti-cancer and anti-inflammatory properties.

SIRT1 inhibitor

COTI-2 activates mutant forms of p53, restoring their native tumor-suppressive conformation and function.

p53-Snail binding Inhibitor

CBL0137 (hydrochloride) is a water-soluble and metabolically stable non-genotoxic anticancer drug from the curaxins small molecule family. It can activate p53 and inhibit NF-κB, with EC 50 values of 0.37 and 0.47μM respectively.

A p53 reactivator

Amifostine, an inorganic thiophosphate, is a selective broad-spectrum cytoprotector of normal tissues.

p-nitro-Cyclic Pifithrin-α (PFN-α) is cell-permeable and active-form p53 inhibitor.

An activator of p53

p-nitro-Pifithrin-α, a cell-permeable analog of pifithrin-α, is a potent p53 inhibitor.

A p53 stabilizing agent

inhibit p53 amyloid formation

A racemic mixture of (?)-nutlin-3 and (+)-nutlin-3

nucleophosmin inhibitor

Restores the p53 signaling pathway

MDM2 inhibitor

An alkaloid with diverse biological activities

SIRT inhibitor and p53 activator