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p53

The p53 tumor suppressor is a 53 kDa nuclear phosphoprotein of 393 amino acids that is encoded by the TP53 gene (20 kb with 11 exons and 10 introns) and characterized by the presence of several structural and functional domains, including a N-terminus, a central core domain, a C-terminal region, a strongly basic carboxyl-terminal regulatory domain, a nuclear localization signal sequence and three nuclear export signal sequence. The p53 is considered as a major “guardian of genome” for its activities in a wide range of cellular events, including cell-cycle regulation, induction of apoptosis, gene amplification, DNA recombination, chromosomal segregation and cellular senescence.

  1. Cat.No. Product Name Information
  2. GC36896 PhiKan 083 hydrochloride
  3. GC10538 Pifithrin-α (PFTα) p53 inhibitor
  4. GC17262 Pifithrin-β potent p53 inhibitor
  5. GC11065 Pifithrin-μ Inhibitor of p53 binding and anti-apoptotic
  6. GC10282 Piperlongumine Inducer of cell-death
  7. GC32946 PK11007
  8. GC10315 Plumbagin Anticancer agent
  9. GC12086 PRIMA-1 BAX inhibitor
  10. GC11247 PRIMA-1MET Restore mutant p53 activity, induce BAX and PUMA
  11. GC15946 ReACp53 inhibit p53 amyloid formation
  12. GC10589 RETRA hydrochloride Antitumor agent
  13. GC13019 RG7112 MDM2 inhibitor, first clinical
  14. GC11594 RG7388 MDM2 antagonist, oral, selective
  15. GC12793 RITA (NSC 652287) Mdm2-p53 interaction and p53 ubiquitination blocking
  16. GC19312 RO8994 RO8994 is a highly potent and selective series of spiroindolinone small-molecule MDM2 inhibitor, with IC50 of 5 nM (HTRF binding assays) and 20 nM (MTT proliferation assays).
  17. GC13590 SJ 172550 MDMX inhibitor
  18. GC16371 Solasodine Neuroprotective antioxidant glycoalkaloid
  19. GC14165 Tenovin-1

    SIRT2 inhibitor, activates p53

  20. GC12337 Tenovin-3 p53 activator
  21. GC16436 Tenovin-6 SIRT inhibitor and p53 activator

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