COX

Celecoxib-d3 is the deuterated form of Celecoxib. Celecoxib is a selective COX-2 inhibitor with an IC50 of 40 nM.

Oxaprozin-d4 is the deuterated form of Oxaprozin.

Phenylbutazone-13C12 is a labeled form of Phenylbutazone with 13 carbon atoms. Phenylbutazone is an effective reducing co-factor for prostaglandin H synthase (PHS) and peroxidase enzymes. It is a hepatotoxin and a nonsteroidal anti-inflammatory drug (NSAID). Phenylbutazone induces the expression of muscleblind-like protein 1 (MBNL1), which has potential for research in ankylosing spondylitis.

Cavidine ((+)-Cavidine) is a selective COX-2 inhibitor which possesses anti-inflammatory activity.

Pelubiprofen, an orally active and non-steroidal anti-inflammatory drug, is a member of the 2-arylpropionic acid family and has relatively selective effects on COX-2 activity.

Indazole-Cl (Ind-Cl) is an Estrogen receptor (ER)-β-specific agonist with inflammatory effect.

Propyphenazone-d3 is the deuterium labeled Propyphenazone.

Flobufen (VUFB 16066) is a non-steroidal anti-inflammatory agent and cyclooxygenase (COX) and 5-lipoxygenase (5-LOX) inhibitor agent.

Salicylic acid-13C6 is the 13C-labeled Salicylic acid.

VU0487836 is a selective cyclooxygenase-1 ( COX-1 ) inhibitor with an IC 50 of 0.36 μM against ovine-derived COX-1.

Desmethyl etoricoxib (example 21) is a selective COX-2 inhibitor with an IC 50 of 1 μM in whole blood.

Bis[2-(4-hydroxyphenylthio) ethoxy]methane (DD-70) is a Bisphenol A substitute and a COX-1 inhibitor.

EGFR/COX-2-IN-3 is a selective EGFR / COX-2 dual inhibitor with IC 50 values of 0.098 μM and 0.05 μM, respectively.

Meloxicam -13C6 is 13 C 6 -labeled Meloxicam.

4'-Acetoxy resveratrol is a Resveratrol derivative.

(S)-Flurbiprofen-d3 (Esflurbiprofen-d3) is the deuterium labeled (S)-Flurbiprofen.

4-Methylamino antipyrine-d 3 -1 is the deuterium labeled 4-Methylamino antipyrine-1.

Allyl thiosulfate (Sodium 2-propenyl thiosulfate) is found in Allium plants such as garlic and onion.

7-O-Galloyl-D-sedoheptulose is an orally effective polyphenolic compound.

4-Methoxycinnamic acid ethyl ester (Ethyl p-methoxycinnamate) is an orally active natural compound found.

A metabolite of various polyphenols

4-Acetamido antipyrine (4-AAAP) is an active metabolite of the non-opioid analgesic and antipyretic prodrug metamizole .

Loxoprofen-SRS is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor (IC50s = 0.5 and 0.39 for recombinant human COX-1 and COX-2, respectively) and an active metabolite of the prodrug loxoprofen .