GLPBio

Histamine Receptor

Histamine receptor has 4 subtypes (H1,H2,H3 and H4) which mediates various biological fuctions, including allergic reaction, gastric acid secretion and inflammation etc.

Products Related to Histamine Receptor(243)

  • GC31026 structure
    GC31026(±)-Tazifylline
    CAS: 79712-55-3
    Purity: >98%

    (±)-Tazifylline is a potent, selective and long-acting histamine H1 receptor antagonist.

  • GC31027 structure
    GC31027MK-0249
    CAS: 862309-06-6
    Purity: >99.50%

    MK-0249 (Compound 1) is a potent, selective and orally active histamine H3 receptor antagonist, with an IC50 of 1.7 nM for human H3.

  • GC31105 structure
    GC31105S 38093
    CAS: 862896-30-8
    Purity: >99.50%

    S 38093 is a brain-penetrant, orally active antagonist of H3 receptor, with Kis of 8.8, 1.44 and 1.2 ?M for rat, mouse and human H3 receptors, respectively.

  • GC31141 structure
    GC31141Antihistamine-1
    CAS: 1186430-60-3
    Purity: >98%

    Antihistamine-1 is a H1-antihistamine (Ki=6.9 nM) with acceptable blood-brain barrier penetration and also an inhibitor of CYP2D6 and hERG channel with IC50s of 5.4 and 0.8 μM, respectively.

  • GC31220 structure
    GC31220Toreforant (JNJ-38518168)
    CAS: 952494-46-1
    Purity: >98%

    Toreforant (JNJ-38518168) is a potent and selective histamine H4 receptor (H4R) antagonist, with a Ki at the human receptor of 8.4 nM.

  • GC31232 structure
    GC31232H4 Receptor antagonist 1
    CAS: 848217-00-5
    Purity: >99.50%

    H4 Receptor antagonist 1 is a potent and selective histamine H4 receptor inverse agonist, with an IC50 of 19 nM.

  • GC31269 structure
    GC31269Cipralisant (GT-2331)
    CAS: 213027-19-1
    Purity: >98%

    Cipralisant (GT-2331) (GT-2331) is an orally active, low-toxicity, potent, selective, high affinity histamine H3 receptor full antagonist in vivo, and an agonist in vitro, with a pKi of 9.9 for histamine H3 receptor and a Ki of 0.47 nM for rat histamine H3 receptor.

  • GC31310 structure
    GC31310H3 receptor antagonist 1
    CAS: 935840-13-4
    Purity: >98%
  • GC31455 structure
    GC31455Niperotidine
    CAS: 84845-75-0
    Purity: >98%

    Niperotidine is a histamine H2-receptor antagonist.

  • GC31695 structure
    GC31695Acrivastine (BW825C)
    CAS: 87848-99-5
    Purity: >98.00%

    Acrivastine (BW825C) (BW825C) is a short acting histamine 1 receptor antagonist for the treatment of allergic rhinitis.

  • GC31708 structure
    GC31708Epinastine (WAL801)
    CAS: 80012-43-7
    Purity: >98.00%

    Epinastine (WAL801) (WAL801) is an antihistamine and mast cell stabilizer.

  • GC31743 structure
    GC31743Mequitazine (LM-209)
    CAS: 29216-28-2
    Purity: >99.50%

    Mequitazine (LM-209) is a potent, and long-acting histamine H1 antagonist.

  • GC31750 structure
    GC31750Fenspiride Hydrochloride
    CAS: 5053-08-7
    Purity: >98%
  • GC31767 structure
    GC31767Peptide 401
    CAS: 32908-73-9
    Purity: >98%

    Peptide 401, a potent mast cell degranulating factor from bee venom, suppresses the increased vascular permeability due to intradermal injection of various smooth muscle spasmogens (histamine, and 5-HT).

  • GC31787 structure
    GC31787Mebhydrolin
    CAS: 524-81-2
    Purity: >99.50%

    Mebhydrolin is a specific histamine H1 receptor antagonist.

  • GC31790 structure
    GC31790PF-3893787 hydrochloride
    CAS: 2096455-90-0
    Purity: >98.00%

    PF-3893787 hydrochloride (PF-3893787 hydrochloride) is a novel histamine H4 receptor antagonist binding affinity (Ki=2.4 nM) and is also a functional (Ki=1.56 nM) antagonist.

  • GC31800 structure
    GC31800SUN 1334H
    CAS: 607736-84-5
    Purity: >98%

    SUN 1334H is a potent, orally active, highly selective H1 receptor antagonist, with Ki of 9.7 nM.

  • GC31812 structure
    GC31812ReN-1869 hydrochloride (NNC-05-1869 hydrochloride)
    CAS: 170149-76-5
    Purity: >98%

    ReN 1869 hydrochloride is a novel, selective histamine H1 receptor antagonist, which demonstrates affinity to the histamine H1 receptor (guinea pig brain) with Ki of 0.19±0.04 μM and the non-selective σ site (guinea pig brain) with Ki of 0.45 μM.

  • GC31820 structure
    GC31820Quinotolast sodium (FR71021)
    CAS: 101193-62-8
    Purity: >98.00%

    Quinotolast sodium (FR71021) in the concentration range of 1-100 μg/mL inhibits histamine, LTC4 and PGD2 release in a concentration-dependent manner.

  • GC31824 structure
    GC31824Wy 49051
    CAS: 113418-56-7
    Purity: >98%

    Wy 49051 is a potent, orally active H1 receptor antagonist, with IC50 of 44 nM.

  • GC31840 structure
    GC31840Bamirastine (TAK-427)
    CAS: 215529-47-8
    Purity: >98%

    Bamirastine (TAK-427) inhibits ligand binding to recombinant human histamine H1 receptors (rhH1R) with an IC50 value of 17.3 nM.

  • GC31848 structure
    GC31848Mebhydrolin napadisylate (Mebhydroline 1,5-naphthalenedisulfonate salt)
    CAS: 6153-33-9
    Purity: >99.50%

    Mebhydrolin napadisylate (Mebhydroline 1,5-naphthalenedisulfonate salt) is a specific histamine H1 receptor antagonist.

  • GC31877 structure
    GC31877BMY-25271
    CAS: 78441-82-4
    Purity: >98%

    BMY-25271 is a histamine H2 receptor antagonist.

  • GC31884 structure
    GC31884H4R antagonist 1
    CAS: 1429375-54-1
    Purity: >98%

    H4R antagonist 1 is a potent and highly selective histamine H4 receptor (H4R) antagonist with an IC50 of 27 nM.