BMY-25271 |
| Catalog No.GC31877 |
BMY-25271 is a histamine H2 receptor antagonist.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 78441-82-4
Sample solution is provided at 25 µL, 10mM.
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BMY-25271 is a histamine H2 receptor antagonist.
BMY-25271 is a histamine H2 receptor antagonist. The dose response curves are parallel and oral ED50 values derived from probit analysis are 0.093, 0.97 and 6.9 mg/kg for BMY-25271, ranitidine and cimetidine, respectively. BMY-25271, therefore, is about 10 and 74 times more potent than ranitidine and cimetidine, respectively. Pretreatment with the highest dose of BMY-25271 does not significantly affect the absorption of aspirin or the formation of its major metabolite, salicylic acid[1].
[1]. Cavanagh RL, et al. Prevention of aspirin-induced gastric mucosal injury by histamine H2 receptor antagonists: a crossover endoscopic and intragastric pH study in the dog. J Pharmacol Exp Ther. 1987 Dec;243(3):1179-84.
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