Androgen Receptor

N-desmethyl Enzalutamide (N-desmethyl MDV 3100) is the active metabolite of Enzalutamide.N-desmethyl Enzalutamide (N-desmethyl MDV 3100) is the active metabolite of Enzalutamide. N-desmethyl Enzalutamide (N-desmethyl MDV 3100) demonstrates primary and secondary pharmacodynamics of similar potency to Enzalutamide and circulates at approximately the same plasma concentrations as enzalutamide.

UT-155 is a selective and potent androgen receptor (AR) antagonist, with a Ki of 267 nM for UT-155 binding to AR-LBD.

Proxalutamide (GT0918) is a novel orally active androgen receptor (AR) antagonist. Proxalutamide can downregulate the expression of TMPRSS2 and ACE2 to inhibit viral entry into host cells, while also reducing inflammation by activating the Nrf2 pathway.

Dehydroepiandrosterone 3-acetate is a testosterone/estrogen precursor and known modulator of vertebrate aggression.

2,2,5,7,8-Pentamethyl-6-Chromanol (PMC) is the anti-oxidant moiety of vitamin E (α-tocopherol). 2,2,5,7,8-Pentamethyl-6-Chromanol has potent androgen receptor (AR) signaling modulation and anti-cancer activity against prostate cancer cell lines.

BMS-564929 is an androgen receptor (AR) agonist, binds to androgen receptor (AR) with a Ki of 2.11±0.16 nM.

Boldenone Undecylenateis a synthetic derivative of testosterone that increases the growth and nutrient conversion of food-producing animals.

Isosilybin B, a flavonolignan isolated from silymarin, has anti-prostate cancer (PCA) activity via inhibiting proliferation and inducing G1 phase arrest and apoptosis. Isosilybin B causes androgen receptor (AR) degradation.

MK-0773 is a selective androgen receptor modulators (SARMs) that binds to AR with an IC50 of 6.6 nM.

11α-hydroxy Testosterone is a metabolite of testosterone, produced by the cytochrome P450 (CYP) isoform CYP3A.

Tibolone is a synthetic steroid that possesses weak estrogenic, progestational and androgenic properties.

17β-hydroxy Exemestane is the primary active metabolite of exemestane.

Neoaureothin is a bacterial metabolite that has been found in Streptomyces.

Nilutamide is a non-steroidal antiandrogen that is an antagonist of the androgen receptor.

p,p'-DDE is a metabolite and degradation product of the organochlorine pesticide DDT.

Prochloraz is an imidazole antifungal that inhibits ergosterol biosynthesis via inhibition of the cytochrome P450-dependent 14α-demethylation of lanosterol, which results in disruption of the fungal cell membrane and cell death.

S-23 is a selective androgen receptor modulator (SARM).

δ4-Abiraterone is a major metabolite of abiraterone. δ4-Abiraterone is an inhibitor of CYP17A1, 3b-hydroxysteroid dehydrogenase (3βHSD) and steroid-5a-reductase (SRD5A) and also an antagonist of androgen receptor.