GLPBio

Androgen Receptor

AR (androgen receptor) is a member of steroid hormone receptor and ligand-activated transcription factor. It plays a crucial role in prostate cellular proliferation and male sexual differentiation.

Products Related to Androgen Receptor(159)

  • GC61481 structure
    GC61481PROTAC AR Degrader-4 TFA
    Purity: >98.00%
  • GC61491 structure
    GC61491(R)-Bicalutamide
    CAS: 113299-40-4
    Purity: >98.00%

    (R)-Bicalutamide is the (R)-enantiomer of Bicalutamide. (R)-Bicalutamide is an androgen receptor (AR) antagonist, with antineoplastic activity. (R)-Bicalutamide is widely used for the research of prostate cancer.

  • GC61850 structure
    GC61850Medroxyprogesterone acetate D3
    Purity: >98.00%
  • GC61971 structure
    GC61971Liarozole
    CAS: 115575-11-6
    Purity: >98.50%

    Liarozole (R75251; R85246) is an imidazole derivative and orally active retinoic acid (RA) metabolism-blocking agent (RAMBA).

  • GC62061 structure
    GC62061Melengestrol acetate
    CAS: 2919-66-6
    Purity: >99.50%

    Melengestrol acetate is a progesterone derivative, acts as an orally active corticosteroid hormone to promote endometrial proliferation, pregnancy maintenance, and delay of menstrual activity.

  • GC62106 structure
    GC62106JNJ-63576253
    CAS: 2110428-64-1
    Purity: >99.00%

    JNJ-63576253 (TRC-253) is a potent and orally active full antagonist of androgen receptor (AR), with IC50s of 37 and 54 nM for F877L mutant AR and wild-type AR in LNCaP cells. JNJ-63576253 can be used for the research of castration-resistant prostate cancer (CRPC).

  • GC62118 structure
    GC62118ARV-110
    CAS: 2222112-77-6
    Purity: >99.00%

    ARV-110 is an orally bioavailable, specific androgen receptor (AR) PROTAC degrader that leads to ubiquitination and degradation of AR.

  • GC62124 structure
    GC62124UT-34
    CAS: 2168525-92-4
    Purity: >98.00%

    UT-34 is a potent, selective and orally active second-generation pan-androgen receptor (AR) antagonist and degrader with IC50s of 211.7 nM, 262.4 nM and 215.7 nM for wild-type, F876L and W741L AR, respectively.

  • GC62209 structure
    GC62209CLP-3094
    CAS: 312749-73-8
    Purity: >99.00%

    CLP-3094 is a potent BF3 (binding function 3)-directed inhibitor of the androgen receptor (AR).

  • GC62249 structure
    GC62249Honokiol DCA
    CAS: 1620160-42-0
    Purity: >98%
  • GC62329 structure
    GC62329VPC-14449
    CAS: 1621375-32-3
    Purity: >98.50%

    VPC-14449 is a potent and selective inhibitor of the DNA-binding domain of the androgen receptor (AR-DBD), with IC50 of 0.34 μM for full-length human AR. VPC-14449 reduces the ability of full-length AR as well as AR variants to interact with chromatin. VPC-14449 can be used for the research of prostate cancer.

  • GC62603 structure
    GC62603Ralaniten triacetate
    CAS: 1637573-04-6
    Purity: >98.50%

    Ralaniten triacetate (EPI-506), the pro-drug of Ralaniten, is a first-in-class, orally active androgen receptor (AR) N-terminal domain (NTD) inhibitor. Ralaniten triacetate shows activity against both full length and resistance-related AR species, including AR-v7.

  • GC62683 structure
    GC62683Ralaniten
    CAS: 1203490-23-6
    Purity: >99.50%

    Ralaniten (EPI-002) is a potent and orally active antagonist of the androgen receptor-N-terminal domain (AR-NTD). Ralaniten inhibits AR transcriptional activity, with IC50 of 7.4 μM. Ralaniten can be used for the research of castration-resistant prostate cancer (CRPC).

  • GC63066 structure
    GC63066Methenolone acetate
    CAS: 434-05-9
    Purity: >99.50%
  • GC63096 structure
    GC63096Nandrolone phenylpropionate
    CAS: 62-90-8
    Purity: >98.00%
  • GC63217 structure
    GC63217Testosterone undecanoate
    CAS: 5949-44-0
    Purity: >98.00%

    Testosterone undecanoate, an orally administered ester prodrug of the anabolic steroid of testosterone, acts as an effective testosterone replacement therapy.

  • GC63292 structure
    GC63292(rac)-PF-998425
    CAS: 1076225-26-7
    Purity: >98%

    (Rac)-PF-998425 is a potent, selective, nonsteroidal androgen receptor (AR) antagonist.

  • GC63402 structure
    GC63402Rezvilutamide
    CAS: 1572045-62-5
    Purity: >99.50%

    Rezvilutamide (SHR3680) is an androgen receptor antagonist. Rezvilutamide (SHR3680) is used for the study of prostate cancer.

  • GC63579 structure
    GC63579Linuron
    CAS: 330-55-2
    Purity: >98.00%

    Linuron is a phenylurea herbicide that is widely used to control the growth of grass and weeds in various agriculture crops and in orchards.

  • GC63764 structure
    GC637647-α-Methylthio Spironolactone-D3
    Purity: >98%
  • GC63935 structure
    GC63935Testosterone buciclate
    CAS: 118931-19-4
    Purity: >98.00%
  • GC64540 structure
    GC64540Ar-V7-IN-1
    CAS: 2230880-25-6
    Purity: >99.00%

    Ar-V7-IN-1 is a potent inhibitor of Ar-V7. AR-V7 is a hormone-independent splice variant of the androgen receptor. Ar-V7-IN-1 has the potential for the research of various indications, in particular cancers such as prostate cancer (extracted from patent WO2018114781A1, compound 43).

  • GC64586 structure
    GC64586Nandrolone laurate
    CAS: 26490-31-3
    Purity: >98%
  • GC64600 structure
    GC64600SK33
    CAS: 1928724-23-5
    Purity: >99.00%

    SK33, a trifluoromethylated enobosarm analog, is a potent, and tissue selective anti-androgen. SK33reduces androgen receptor (AR) transcriptional activity.