ER 819762 |
| Catalog No.GC50722 |
ER 819762 is an orally active, highly selective prostaglandin E2 (PGE2) EP4 receptor antagonist with an EC50 of 70 nM against human EP4 receptor.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1155773-15-1
Sample solution is provided at 25 µL, 10mM.
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Potent EP4 receptor antagonist (IC50 = 59 nM). Suppresses EP4-mediated Th1 differentiation, Th17 cell expansion, and IL-23 secretion by activated dendritic cells. Inhibits Th1 and Th17 cytokine production, suppresses collagen- and GPI-induced arthritis in mice. Attenuates CFA-induced inflammatory pain in rats. Analgesic. Orally bioavailable.
Average Rating: 5 (Based on Reviews and 36 reference(s) in Google Scholar.)
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