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Home >> Signaling Pathways >> GPCR/G protein >> Sigma Receptor

Sigma Receptor

Sigma receptors are non-opioid receptors that interacted with psychostimulants such as cocaine and methamphetamine. It is associated with central nervous systems diseases, cancer and neuropathic pain etc.

Products for  Sigma Receptor

  1. Cat.No. Product Name Information
  2. GC62708 σ1 Receptor antagonist-1 σ1 Receptor antagonist-1 is a highly potent and selective sigma 1 receptor antagonist (pKi=10.28). σ1 Receptor antagonist-1 Chemical Structure
  3. GC15144 (±)-PPCC oxalate sigma (σ) receptor ligand (±)-PPCC oxalate Chemical Structure
  4. GC18146 (+)-Igmesine hydrochloride σ1 receptor ligand (+)-Igmesine hydrochloride Chemical Structure
  5. GC17301 (+)-SK&F 10047 hydrochloride prototypical σ1 receptor agonist (+)-SK&F 10047 hydrochloride Chemical Structure
  6. GC50048 (+/-)-PPCC oxalate Selective sigma (σ) agonist (σ1> σ2) (+/-)-PPCC oxalate Chemical Structure
  7. GC38712 (2R,3R)-E1R (2R,3R)-E1R (Compound 2b) is an enantiomer of E1R. (2R,3R)-E1R Chemical Structure
  8. GC38713 (2R,3S)-E1R (2R,3S)-E1R (Compound 2c) is an enantiomer of E1R. (2R,3S)-E1R Chemical Structure
  9. GC38714 (2S,3S)-E1R (2S,3S)-E1R (Compound 2d) is an enantiomer of E1R. (2S,3S)-E1R Chemical Structure
  10. GC38721 (Rac)-E1R (Rac)-E1R (Compound 2) is the racemate of E1R. (Rac)-E1R Chemical Structure
  11. GC17723 4-IBP

    NSC 667672

     σ1 agonist 4-IBP Chemical Structure
  12. GC13357 4-PPBP maleate σ ligand and NR1a/2B NMDA receptors antagonist 4-PPBP maleate Chemical Structure
  13. GC71107 AB21 hydrochloride AB21 hydrochloride is a potent and selective S1R antagonist with Kis of 13, 102 nM for S1R and S2R. AB21 hydrochloride Chemical Structure
  14. GC19032 AVex-73 hydrochloride

    Anavex 2-73

     AVex-73 hydrochloride is a Sigma-1 Receptor agonist with an IC50 of 860 nM. AVex-73 hydrochloride Chemical Structure
  15. GC16595 BD 1008 dihydrobromide δ1-receptor antagonist,potent and selective BD 1008 dihydrobromide Chemical Structure
  16. GC15374 BD 1047 dihydrobromide σ1 receptor antagonist BD 1047 dihydrobromide Chemical Structure
  17. GC15838 BD 1063 dihydrochloride BD 1063 dihydrochloride is a potent and selective sigma 1 receptor antagonist. BD 1063 dihydrochloride Chemical Structure
  18. GC13796 BMY 14802 hydrochloride

    BMY-14802-1; BMS 181100 hydrochloride

     Sigma receptor antagonist BMY 14802 hydrochloride Chemical Structure
  19. GC63801 CM398 CM398 is a highly selective, orally active sigma-2 receptor ligand (Ki=0.43 nM), with high sigma-1/sigma-2 selectivity rato (1000-fold). CM398 Chemical Structure
  20. GC65450 CT1812

    Sigma-2 receptor antagonist 1

     CT1812 (Sigma-2 receptor antagonist 1) is a sigma-2 (σ-2) receptor antagonist. CT1812 Chemical Structure
  21. GC33697 Cutamesine (SA4503) Cutamesine (SA4503) is a potent and selective agonist for the sigma 1 receptor subtype in the brain. Cutamesine (SA4503) Chemical Structure
  22. GC30956 Dimemorfan phosphate Dimemorfan phosphate is a sigma 1 receptor agonist, used as a potent antitussive. Dimemorfan phosphate Chemical Structure
  23. GC16598 DTG

    NSC 132023, DTG, NSC 473

     DTG (1,3-Di-o-tolylguanidine) is an agonist of sigma receptor (σ1/σ2 receptor). DTG Chemical Structure
  24. GC61822 DuP 734 DuP 734 is a sigma receptor antagonist. DuP 734 Chemical Structure
  25. GC35923 E1R E1R is a positive allosteric modulator of sigma-1 receptors (Sig1R PAM) with cognition-enhancing activity. E1R Chemical Structure
  26. GC62959 EST64454 hydrochloride EST64454 hydrochloride is a selective and orally active sigma-1 receptor antagonist with a Ki of 22 nM. EST64454 hydrochloride Chemical Structure
  27. GC62960 EST73502 hydrochloride EST73502 hydrochloride is a selective, orally active and blood-brain barrier (BBB) penetrant dual μ-opioid receptor (MOR) agonist and σ1 receptor (σ1R) antagonist, with Kis of 64 nM and 118 nM for MOR and σ1R, respectively. EST73502 hydrochloride Chemical Structure
  28. GC17721 IPAG Potent σ-receptor antagonist IPAG Chemical Structure
  29. GC60216 KB-5492 anhydrous KB-5492 anhydrous is a potent and selective inhibitor of sigma receptor, inhibits specific [3H]1,3-di(2-tolyl)guanidine (DTG) binding to the sigma receptor with an IC50 of 3.15 μM. KB-5492 anhydrous Chemical Structure
  30. GC65178 KB-5492 free base KB-5492 free base is a potent and selective inhibitor of sigma receptor, inhibits specific [3H]1,3-di(2-tolyl)guanidine (DTG) binding to the sigma receptor with an IC50 of 3.15 μM. KB-5492 free base Chemical Structure
  31. GC12490 L-693,403 maleate High affinity σ ligand L-693,403 maleate Chemical Structure
  32. GC17380 Metaphit Acylator of PCP and σ-receptors Metaphit Chemical Structure
  33. GC15465 N-[2-(Piperidinylamino)ethyl]-4-iodobenzamide σ-1 selective ligand N-[2-(Piperidinylamino)ethyl]-4-iodobenzamide Chemical Structure
  34. GC16004 NE 100 hydrochloride

    σ1 receptor antagonist

     NE 100 hydrochloride Chemical Structure
  35. GC32821 Noscapine ((S,R)-Noscapine) Noscapine ((S,R)-Noscapine) Chemical Structure
  36. GC61889 OPC-14523 hydrochloride OPC-14523 hydrochloride is an orally active sigma and 5-HT1A receptor agonist, with high affinity for sigma receptors (σ1/2 IC50=47/56 nM), the 5-HT1A receptor (IC50=2.3 nM), and the 5-HT transporter (IC50=80 nM). OPC-14523 hydrochloride Chemical Structure
  37. GC61926 Panamesine

    EMD 57445

     Panamesine (EMD 57445) is a sigma receptor ligand, which has a high affinity (IC50 6 nM) and selectivity for sigma binding sites. Panamesine Chemical Structure
  38. GC17392 PB 28 dihydrochloride σ2 receptor agonist PB 28 dihydrochloride Chemical Structure
  39. GC11187 PD 144418 oxalate PD 144418 oxalate is a highly affinity, potent and selective sigma 1 (σ1) receptor ligand (Ki values of 0.08 nM and 1377 nM for σ1 and σ2 respectively). PD 144418 oxalate Chemical Structure
  40. GC61838 Pentoxyverine Pentoxyverine (Carbetapentane) is a sigma-1 receptor agonist, with a Ki of 75 nM on guinea-pig brain membranes. Pentoxyverine Chemical Structure
  41. GC14960 PRE-084 hydrochloride selective σ1 receptor agonist PRE-084 hydrochloride Chemical Structure
  42. GC10795 Rimcazole dihydrochloride

    σ receptors antagonist

     Rimcazole dihydrochloride Chemical Structure
  43. GC30206 Roluperidone (CYR-101)

    CYR-101; MIN-101; MT-210

     Roluperidone (CYR-101) (CYR-101) is a novel cyclic amide derivative that has high equipotent affinities for 5-HT2A and sigma-2 receptors (Ki of 7.53 nM and 8.19 nM for 5-HT2A and sigma-2, respectively). Roluperidone (CYR-101) Chemical Structure
  44. GC73273 S1R agonist 1 S1R agonist 1 (Compound 6b) is a selective S1R agonist with Kis of 0.93 nM and 72 nM for S1R and S2R, respectively. S1R agonist 1 Chemical Structure
  45. GC71102 S1R agonist 1 hydrochloride S1R agonist 1 (Compound 6b) hydrochloride is a selective S1R agonist with Kis of 0.93 nM and 72 nM for S1R and S2R, respectively. S1R agonist 1 hydrochloride Chemical Structure
  46. GC71103 S1R agonist 2 S1R agonist 2 (Compound 8b) is a selective S1R agonist with Kis of 1.1 nM and 88 nM for S1R and S2R, respectively. S1R agonist 2 Chemical Structure
  47. GC71104 S1R agonist 2 hydrochloride S1R agonist 2 (Compound 8b) hydrochloride is a selective S1R agonist with Kis of 1.1 nM and 88 nM for S1R and S2R, respectively. S1R agonist 2 hydrochloride Chemical Structure
  48. GC10407 S1RA

    E-52862

     σ1R antagonist S1RA Chemical Structure
  49. GC13911 S1RA hydrochloride

    E-52862, P 027

     σ1R antagonist S1RA hydrochloride Chemical Structure
  50. GC17088 SA 4503 dihydrochloride

    AGY 94806, Cutamesine

     SA 4503 dihydrochloride (SA4503 dihydrochloride; AGY94806 dihydrochloride) is a potent Sigma 1 receptor agonist with an IC50 of 17.4 nM in guinea pig brain membranes. SA 4503 dihydrochloride Chemical Structure
  51. GC38038 Sigma-1 receptor antagonist 1 Sigma?1 receptor antagonist 1 (compound 137) is a potent and selective sigma-1 receptor (σ1R) antagonist, with a high binding affinity to σ1R receptor (Ki = 1.06 nM). Sigma-1 receptor antagonist 1 Chemical Structure
  52. GC38039 Sigma-1 receptor antagonist 2 Sigma-1 receptor antagonist 2 is a potent and selective sigma 1 receptor (σ1 R) antagonist with Kis of 3.88 and 1288 nM for σ1 and σ2 receptor, respectively. Sigma-1 receptor antagonist 2 Chemical Structure
  53. GC38048 Sigma-1 receptor antagonist 3 Sigma-1 receptor antagonist 3 (compound135) is a potent and selective Sigma-1 (σ1) receptor antagonist with a Ki of 1.14 nM. Sigma-1 receptor antagonist 3 Chemical Structure
  54. GC31294 Sigma-LIGAND-1 Sigma-LIGAND-1 is a selective sigma receptor ligand with an IC50s of 16 nM, 19 nM at the DTG site and the PPP site, respectively. Sigma-LIGAND-1 Chemical Structure
  55. GC67893 Sigma-LIGAND-1 hydrochloride Sigma-LIGAND-1 hydrochloride Chemical Structure
  56. GC13083 Siramesine

    Lu 28-179

     Siramesine (Lu 28-179) is a potent sigma-2 receptor agonist. Siramesine has a subnanomolar affinity for sigma-2 receptors (IC50=0.12nM) and exhibits a 140-fold selectivity for sigma-2 receptors over sigma-1 receptors (IC50=17nM). Siramesine triggers cell death through destabilisation of mitochondria, but not lysosomes. Anti-cancer activity. Siramesine Chemical Structure
  57. GC15222 Siramesine hydrochloride

    Sigma-2 receptor agonist

     Siramesine hydrochloride Chemical Structure
  58. GC16473 TC 1 σ1 receptor ligand TC 1 Chemical Structure
  59. GC14249 UNC 0642 G9a and GLP histone lysine methyltransferase inhibitor UNC 0642 Chemical Structure

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