Innate Immunity

1-Arachidonoyl lysophosphatidic acid is a phospholipid containing arachidonic acid at the sn-1 position.

1-Methyl-4-imidazoleacetic acid (MIMA) is a stable metabolite of histamine that is produced by the oxidation of the primary metabolite, N-methylhistamine.

1-Palmitoyl-2-hydroxy-sn-glycero-3-PC is an abundant gonadal LPC (lysophosphatidylcholine).

1-Palmitoyl-2-stearoyl-3-oleoyl-rac-glycerol is a triacylglycerol that contains palmitic, stearic, and oleic acid at the sn-1, sn-2, and sn-3 positions, respectively.

2'2'-cGAMP is a synthetic dinucleotide (CDN) that contains non-canonical 2'5'-phosphodiester bonds.

20-carboxy LTB4 is a metabolite of LTB4 in human neutrophils.

2-Aminopurine (hydrochloride) is a fluorescent analog of guanosine.

2-chloro Palmitic Acid, an inflammatory lipid mediator, interferes with protein palmitoylation,induces ER-stress markers, reduced the ER ATP content, and activates transcription and secretion of IL-6 as well as IL-8.2-chloro Palmitic Acid disrupts the mitochondrial membrane potential and induces procaspase-3 and PARP cleavage.2-chloro Palmitic Acid can across blood-brain barrier (BBB) and compromises ER- and mitochondrial functions in the human brain endothelial cell line hCMEC/D3.

2-chloro Stearic acid is a bioactive fatty acid that accumulates in primary human monocytes and neutrophils as well as murine neutrophils stimulated with phorbol 12-myristate 13-acetate.

3'-sulfo Galactosylsphingosine is a form of sulfatide that is lacking the fatty acyl group.

3-Bromotyrosine is a product of protein oxidation found after activation of eosinophils during an allergic response.

3-Bromotyrosine-13C9,15N is intended for use as an internal standard for the quantification of 3-bromotyrosine by GC- or LC-MS.

4-Aminobenzoic Acid hydrazide is an irreversible MPO myeloperoxidase inhibitor with an IC50 of 0.3 μM.

4-Deoxypyridoxine (4-DPD) is a vitamin B6 antimetabolite with diverse biological activities.

Chlortetracycline is an analog of tetracycline, a broad spectrum antibiotic.

8-Bromoguanosine is a brominated derivative of guanosine.

Abz-Ala-Pro-Glu-Glu-Ile-Met-Arg-Arg-Gln-EDDnp is a fluorescence-quenched peptide substrate for human neutrophil elastase (kcat/Km = 531 mM-1s-1).

Abz-Val-Ala-Asp-Nva-Arg-Asp-Arg-Gln-EDDnp (trifluoroacetate salt) is a modified peptide containing fluorescence resonance energy transfer (FRET) groups.

Ac-ANW-AMC is a fluorescent substrate for the β5i (LMP7/PSMB8) subunit of the 20S immunoproteasome, with a maximum excitation wavelength of λEx=345nm and a maximum emission wavelength of λEm=445nm.

Ac-IEPD-AMC is a fluorogenic substrate for granzyme B.

Adrenomedullin (1-50) is a peptide hormone with RNA expressed in rat adrenal glands, lung, kidney, heart, and spleen, as well as in the duodenum and submandibular glands.

Adrenomedullin (1-52) is a peptide with diverse biological activities.

Alamethicin F50 is a peptaibol isolated from Trichoderma.

APC 366 is a mast cell tryptase inhibitor (Ki = 7.1 μM for human recombinant enzyme).