NF-κB
NF-κB is a family of conserved and ubiquitous transcription factors that involved in various biological processes including immunity, inflammation, cell growth, differentiation and apoptosis. It is associated with cancer, chronic inflammation and arthritis etc.
Products for NF-κB
- Cat.No. Product Name Information
- GN10584 Ginsenoside Rk1
- GC31817 Ginsenoside Rk3 Ginsenoside Rk3 is present in the roots Panax notoginseng herbs.
- GC17255 Gliotoxin An immunosuppressive mycotoxin with diverse biological effects
- GC60180 Gossypin A flavonoid glycoside with diverse biological activities
-
GC43786
GS-143
GS-143 is an inhibitor of IκBα ubiquitylation.
- GC41218 Guaiacol Guaiacol is a phenolic natural product first isolated from Guaiac resin and the oxidation of lignin.
- GC43810 Helenalin Helenalin is a sesquiterpene lactone first isolated from various species of Arnica.
- GC60897 Hesperidin methylchalcone Hesperidin methylchalcone (Hesperidin methyl chalcone) inhibits oxidative stress, cytokine production and NF-κB activation.
- GC31692 Homoplantaginin A flavonoid glycoside with antioxidant and anti-inflammatory activities
- GC13074 HU 211 NMDA antagonist, novel and non-competitive
- GC36301 IKKγ NBD Inhibitory Peptide IKKγ NBD Inhibitory Peptide is a NEMO-binding domain peptide (NBD peptide) corresponding to the NEMO amino-terminal alpha-helical region, which is shown to block TNF-alpha-induced NF-kB activation.
- GC16368 Indole-3-carbinol anticarcinogenic drug
- GC33861 Inulicin (1-O-Acetylbritannilactone) Inulicin (1-O-Acetylbritannilactone) (1-O-Acetylbritannilactone) is an active compound that inhibits VEGF-mediated activation of Src and FAK.
- GC39109 Isodeoxyelephantopin Isodeoxyelephantopin is a sesquiterpene lactone isolated from Elephantopus scaber. Isodeoxyelephantopin induces ROS generation, suppresses NF-κB activation. Isodeoxyelephantopin also modulates LncRNA expression and exhibit activities against breast cancer.
- GC39095 Isoliquiritin apioside Isoliquiritin apioside significantly decreases PMA-induced increases in MMP9 activities and suppresses PMA-induced activation of MAPK and NF-κB. Isoliquiritin apioside auppresseses invasiveness and angiogenesis of cancer cells and endothelial cells.
- GC41273 Isoquercetin Isoquercetin is a flavonoid that has been isolated from A.
- GN10804 Isovitexin
- GC33844 Isovitexin (Saponaretin) A C-glycosylated flavone with diverse biological activities
-
GC11438
JSH-23
JSH-23, exhibited inhibitory effect on nuclear translocation and NF-κB transcriptional activity with an IC50 value of 7.1 µM in lipopolysaccharide (LPS)-stimulated macrophages RAW 264.7.
-
GC39093
Kamebakaurin
Kamebakaurin, a compound of kaurane diterpenes was isolated from traditional Chinese medicinal plant Isodon excia.
- GC44085 L-Sulforaphene L-Sulforaphene, isolated from radish seeds, exhibits an ED50 against velvetleaf seedlings approximately 2 x 10-4 M. L-Sulforaphene promotes cancer cells apoptosis and inhibits migration via inhibiting EGFR, p-ERK1/2, NF‐κB and other signals.
- GC10474 Laquinimod (ABR-215062) Laquinimod (ABR-215062) (ABR-215062), an orally available carboxamide derivative, is a potent immunomodulator which prevents neurodegeneration and inflammation in the central nervous system.
- GC36446 Licochalcone D Licochalcone D, a flavonoid compound mainly existing in the root of Glycyrrhiza inflate, is a potent and orally active inhibitor of NF-kappaB (NF-κB) p65.
- GC36456 Licoricidin Licoricidin (LCD) is isolated from Glycyrrhiza uralensis Fisch, possesses anti-cancer activities.
- GC17608 Lidocaine Anasthetic and class Ib antiarrhythmic agent
- GC33831 Lidocaine hydrochloride (Lignocaine hydrochloride) Lidocaine hydrochloride (Lignocaine hydrochloride) (Lignocaine hydrochloride) inhibits sodium channels involving complex voltage and using dependence.
- GC61021 Malachite green oxalate Malachite green oxalate is a triphenylmethane dye which can be used to detect the release of phosphate in enzymatic reactions. Malachite green oxalate is also a potent and selective inhibitor of IKBKE, and inhibits its downstream targets such as IκBα, p65 and IRF3. Malachite green oxalate exhibits antitumor activity in vitro and in vivo.
- GN10491 Mangiferin
- GC17632 Maslinic Acid inhibitor of NO, H2O2 , IL-6 and TNF-α
- GC16607 Mesalamine 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB.
- GC61043 Mesalamine impurity P Mesalamine impurity P is an impurity of Mesalamine.
- GC49241 Methyl Diethyldithiocarbamate An active metabolite of disulfiram
- GC16007 Methylthiouracil antithyroid preparation
-
GC44238
Mn(III)TBAP
Mn(III)TBAP is a cell-permeable SOD mimic.
- GN10436 Morusin
- GC17279 N-3-oxo-dodecanoyl-L-Homoserine lactone NF-κB and AP-2 activator
- GC36696 Naringin Dihydrochalcone A flavonoid with antioxidant activity
-
GC69539
Nasunin
Nasunin is an antioxidant anthocyanin with anti-angiogenic activity.
- GC44353 NDMC101 A salicylanilide derivative
- GN10103 Neferine
- GN10429 Neochlorogenic acid
- GC60267 Neocryptotanshinone Neocryptotanshinone, a fatty diterpenoids from Salvia Miltiorrhiza, inhibits lipopolysaccharide-induced inflammation by suppression of NF-κB and iNOS signaling pathways.
- GC48985 NF-κB Inhibitor (trifluoroacetate salt) A cell-permeable peptide that blocks nuclear import of NF-κB
-
GC69555
NF-κB-IN-4
NF-κB-IN-4 (compound 17) is an effective NF-κB pathway inhibitor that can penetrate the blood-brain barrier. NF-κB-IN-4 exhibits potential low toxicity and anti-neuroinflammatory activity. It can block the activation and phosphorylation of IκBα, reduce the expression of NLRP3, and thus inhibit the activation of NF-κB. NF-κB-IN-4 can be used for research on neuroinflammatory-related diseases.
-
GC69556
NF-κB/MAPK-IN-1
NF-κB/MAPK-IN-1 (compound 11a) is an effective inhibitor of the NF-κB and MAPK pathways. It has inhibitory effects on NO production, with an IC50 of 6.96 μM. NF-κB/MAPK-IN-1 also inhibits LPS-induced iNOS, COX-2, ERα, and P38 activation. It can inhibit macrophage inflammatory response induced by LPS. NF-κB/MAPK-IN-1 can be used for research on rheumatoid arthritis (RA).
- GC11736 NF-κB Activation Inhibitor III NF-κB Activation Inhibitor III is a potent NF-kB inhibitor that targets downstream of MAPK p38 activation. NF-κB Activation Inhibitor III inhibits TNF-α-induced MMP-9 upregulation. NF-κB Activation Inhibitor III can be used for the research of chemotherapies targeting TNF-α-mediated tumor invasion and metastasis .
-
GC31733
NIK SMI1
NIK SMI1 is a potent, selective NF-κB inducing kinase (NIK) inhibitor, which inhibits NIK-catalyzed hydrolysis of ATP to ADP with IC50 of 0.23±0.17 nM.
- GC36794 Okanin Okanin, effective constituent of the flower tea Coreopsis tinctoria, attenuates LPS-induced microglial activation through inhibition of the TLR4/NF-κB signaling pathways.
- GC12114 Oxaprozin COX inhibitor
- GC49024 Palmitic Acid MaxSpec® Standard A quantitative analytical standard guaranteed to meet MaxSpec® identity, purity, stability, and concentration specifications
- GC49023 Palmitic Acid-d9 MaxSpec® Standard A quantitative analytical standard guaranteed to meet MaxSpec® identity, purity, stability, and concentration specifications
- GN10357 Parthenolide
- GC60283 Pentagamavunon-1 Pentagamavunon-1 (PGV-1), a Curcumin analog with oral activity, targets on several molecular mechanisms to induce apoptosis including inhibition of angiogenic factors cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF). PGV-1 inhibits NF-κB activation.
- GC38170 Phellodendrine
- GN10778 Picroside II
- GN10312 Polygalasaponin F
- GC16657 PPM-18 NF-κB inhibitor
- GC16096 PR 39 (porcine) PR 39 (porcine), a natural proline- and arginine-rich antibacterial peptide, is a noncompetitive, reversible and allosteric proteasome inhibitor.
- GC37036 PTD-p65-P1 Peptide PTD-p65-P1 Peptide is a potent, selective nuclear transcription factor NF-κB inhibitor and derives from the p65 subunit of NF-κB amino acid residues 271-282, which selectively inhibits NF-κB activation induced by various inflammatory stimulation, down-regulate NF-κB-mediated gene expression and up-regulate apoptosis.
- GC38520 PTD-p65-P1 Peptide TFA PTD-p65-P1 Peptide TFA is a potent, selective nuclear transcription factor NF-κB inhibitor and derives from the p65 subunit of NF-κB amino acid residues 271-282, which selectively inhibits NF-κB activation induced by various inflammatory stimulation, down-regulate NF-κB-mediated gene expression and up-regulate apoptosis.
- GC49860 Pyropheophorbide a methyl ester Pyropheophorbide a methyl ester (Pyropheophorbide-a methyl ester), a chlorophyll-a derivative, is a potent photosensitizer that can be used in photodynamic therapy (PDT) of cancer. Pyropheophorbide a methyl ester has photodynamic activity and can induce apoptosis and inhibit tumor growth.
- GC13575 Pyrrolidinedithiocarbamate ammonium A NF-κB inhibitor
- GC11751 QNZ (EVP4593) An inhibitor of NF-κB activation
- GC39428 Quinoclamine Quinoclamine, a naphthoquinone derivative, is a NF-κB inhibitor. Quinoclamine exhibits anti-cancer activity.
- GC39081 Reticuline Reticuline shows anti-inflammatory effects through JAK2/STAT3 and NF-κB signaling pathways.
- GN10784 Rhoifolin
- GN10185 Rhynchophylline
- GC16874 Ro 106-9920 Inhibitor of NF-κB activation
-
GC19548
Rocaglamide
Rocaglamide is a potent NF-κB activation inhibitor.
-
GC33426
Rocaglamide (Rocaglamide A)
Rocaglamide (Rocaglamide A) is isolated from the genus Aglaia (family Meliaceae).
- GC60331 Rubiadin-1-methyl ether Rubiadin-1-methyl ether is a natural anthraquinone isolated from Morinda officinalis How, and inhibits osteoclastic bone resorption via inhibition on the phosphorylation of NF-κB p65 and the degradation of IκBα as well as decrease in the nuclear translocation of p65.
- GN10164 Saikosaponin D
- GN10759 Sanggenone C
- GN10260 Sarsasapogenin
- GC10088 SC75741 NF-κB inhibitor, potent
- GN10368 Schisantherin A
- GC45561 Sciadopitysin
- GC68141 SEMBL
- GN10216 Shikonin
- GC49002 Sinigrin (hydrate) A glucosinolate with diverse biological activities
- GN10213 Sinomenine Hydrochloride
- GC49049 SMU127 An agonist of TLR1/2
-
GC31642
SN50
SN50, the NF-κB cell permeable inhibitory peptide.
- GC10933 Sodium 4-Aminosalicylate Sodium 4-Aminosalicylate (4-Aminosalicylic acid sodium salt dihydrate) is one of the antimycobacterial drugs currently used for multidrug-resistant tuberculosis.
-
GC12013
Sodium salicylate
NF-κB inhibitor
- GC50139 SP 100030 NF-κB and AP-1 dual inhibitor
- GC37686 Stachydrine Stachydrine is a major constituent of Chinese herb leonurus heterophyllus sweet used to promote blood circulation and dispel blood stasis.
- GC13840 Stachydrine (hydrochloride) anti-metastatic agent
- GC49844 Stercobilin (hydrochloride) A fecal pigment and metabolite of bilirubin
- GC11819 Strontium Ranelate Calcium Channel activator
- GC38984 Suberosin Suberosin, isolated from Plumbago zeylanica, exhibits anti-inflammatory and anticoagulant activity.
- GC16868 Sulfasalazine NF-κB activation inhibitor
- GC32737 TAK-243 (MLN7243) TAK-243 (MLN7243) (MLN7243) is a first-in-class, selective ubiquitin activating enzyme, UAE (UBA1) inhibitor (IC50=1 nM), which blocks ubiquitin conjugation, disrupting monoubiquitin signaling as well as global protein ubiquitination. TAK-243 (MLN7243) (MLN7243) induces endoplasmic reticulum (ER) stress, abrogates NF-κB pathway activation and promotes apoptosis.
-
GC60352
Taraxerol
Taraxerol has anti-inflammatory and anticancer effects.
- GC34171 Tectochrysin (Techtochrysin) Tectochrysin (Techtochrysin) (Techtochrysin) is one of the major flavonoids of Alpinia oxyphylla Miquel. Tectochrysin (Techtochrysin) inhibits activity of NF-κB.
-
GC41573
Theaflavin 3,3'-digallate
Theaflavin-3,3'-digallate (TFDG) is a major polyphenol found in black tea with diverse biological activities.
- GC31647 Tomatidine Tomatidine acts as an anti-inflammatory agent by blocking NF-κB and JNK signaling.
- GC45064 Tomatidine (hydrochloride) Tomatidine is a steroidal alkaloid that has been found in the skins and leaves of tomatoes.
- GC38868 TRAF-STOP inhibitor 6877002 TRAF-STOP inhibitor 6877002, is a selective inhibitor of CD40-TRAF6 interaction, compound VII, shows inhibition of NF-κB activation in RAW cells, extracted from patent WO2014033122A1.
- GC48202 Treprostinil (diethanolamine salt) Treprostinil (UT-15C) diethanolamine is a potent EP2, DP1 and IP agonist with Ki values of 3.6, 4.4, 32.1, 212, 826, 2505 and 4680 nM for EP2, DP1, IP, EP1, EP4, EP3 and FP, respectively.