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NF-κB

NF-κB is a family of conserved and ubiquitous transcription factors that involved in various biological processes including immunity, inflammation, cell growth, differentiation and apoptosis. It is associated with cancer, chronic inflammation and arthritis etc.

Products for  NF-κB

  1. Cat.No. Product Name Information
  2. GN10584 Ginsenoside Rk1 Ginsenoside Rk1  Chemical Structure
  3. GC31817 Ginsenoside Rk3 Ginsenoside Rk3 is present in the roots Panax notoginseng herbs. Ginsenoside Rk3  Chemical Structure
  4. GC17255 Gliotoxin An immunosuppressive mycotoxin with diverse biological effects Gliotoxin  Chemical Structure
  5. GC60180 Gossypin A flavonoid glycoside with diverse biological activities Gossypin  Chemical Structure
  6. GC43786 GS-143

    GS-143 is an inhibitor of IκBα ubiquitylation.

    GS-143  Chemical Structure
  7. GC41218 Guaiacol Guaiacol is a phenolic natural product first isolated from Guaiac resin and the oxidation of lignin. Guaiacol  Chemical Structure
  8. GC43810 Helenalin Helenalin is a sesquiterpene lactone first isolated from various species of Arnica. Helenalin  Chemical Structure
  9. GC60897 Hesperidin methylchalcone Hesperidin methylchalcone (Hesperidin methyl chalcone) inhibits oxidative stress, cytokine production and NF-κB activation. Hesperidin methylchalcone  Chemical Structure
  10. GC31692 Homoplantaginin A flavonoid glycoside with antioxidant and anti-inflammatory activities Homoplantaginin  Chemical Structure
  11. GC13074 HU 211 NMDA antagonist, novel and non-competitive HU 211  Chemical Structure
  12. GC36301 IKKγ NBD Inhibitory Peptide IKKγ NBD Inhibitory Peptide is a NEMO-binding domain peptide (NBD peptide) corresponding to the NEMO amino-terminal alpha-helical region, which is shown to block TNF-alpha-induced NF-kB activation. IKKγ NBD Inhibitory Peptide  Chemical Structure
  13. GC16368 Indole-3-carbinol anticarcinogenic drug Indole-3-carbinol  Chemical Structure
  14. GC33861 Inulicin (1-O-Acetylbritannilactone) Inulicin (1-O-Acetylbritannilactone) (1-O-Acetylbritannilactone) is an active compound that inhibits VEGF-mediated activation of Src and FAK. Inulicin (1-O-Acetylbritannilactone)  Chemical Structure
  15. GC39109 Isodeoxyelephantopin Isodeoxyelephantopin is a sesquiterpene lactone isolated from Elephantopus scaber. Isodeoxyelephantopin induces ROS generation, suppresses NF-κB activation. Isodeoxyelephantopin also modulates LncRNA expression and exhibit activities against breast cancer. Isodeoxyelephantopin  Chemical Structure
  16. GC39095 Isoliquiritin apioside Isoliquiritin apioside significantly decreases PMA-induced increases in MMP9 activities and suppresses PMA-induced activation of MAPK and NF-κB. Isoliquiritin apioside auppresseses invasiveness and angiogenesis of cancer cells and endothelial cells. Isoliquiritin apioside  Chemical Structure
  17. GC41273 Isoquercetin Isoquercetin is a flavonoid that has been isolated from A. Isoquercetin  Chemical Structure
  18. GN10804 Isovitexin Isovitexin  Chemical Structure
  19. GC33844 Isovitexin (Saponaretin) A C-glycosylated flavone with diverse biological activities Isovitexin (Saponaretin)  Chemical Structure
  20. GC11438 JSH-23

    JSH-23, exhibited inhibitory effect on nuclear translocation and NF-κB transcriptional activity with an IC50 value of 7.1 µM in lipopolysaccharide (LPS)-stimulated macrophages RAW 264.7.

    JSH-23  Chemical Structure
  21. GC39093 Kamebakaurin

    Kamebakaurin, a compound of kaurane diterpenes was isolated from traditional Chinese medicinal plant Isodon excia.

    Kamebakaurin  Chemical Structure
  22. GC44085 L-Sulforaphene L-Sulforaphene, isolated from radish seeds, exhibits an ED50 against velvetleaf seedlings approximately 2 x 10-4 M. L-Sulforaphene promotes cancer cells apoptosis and inhibits migration via inhibiting EGFR, p-ERK1/2, NF‐κB and other signals. L-Sulforaphene  Chemical Structure
  23. GC10474 Laquinimod (ABR-215062) Laquinimod (ABR-215062) (ABR-215062), an orally available carboxamide derivative, is a potent immunomodulator which prevents neurodegeneration and inflammation in the central nervous system. Laquinimod (ABR-215062)  Chemical Structure
  24. GC36446 Licochalcone D Licochalcone D, a flavonoid compound mainly existing in the root of Glycyrrhiza inflate, is a potent and orally active inhibitor of NF-kappaB (NF-κB) p65. Licochalcone D  Chemical Structure
  25. GC36456 Licoricidin Licoricidin (LCD) is isolated from Glycyrrhiza uralensis Fisch, possesses anti-cancer activities. Licoricidin  Chemical Structure
  26. GC17608 Lidocaine Anasthetic and class Ib antiarrhythmic agent Lidocaine  Chemical Structure
  27. GC33831 Lidocaine hydrochloride (Lignocaine hydrochloride) Lidocaine hydrochloride (Lignocaine hydrochloride) (Lignocaine hydrochloride) inhibits sodium channels involving complex voltage and using dependence. Lidocaine hydrochloride (Lignocaine hydrochloride)  Chemical Structure
  28. GC61021 Malachite green oxalate Malachite green oxalate is a triphenylmethane dye which can be used to detect the release of phosphate in enzymatic reactions. Malachite green oxalate is also a potent and selective inhibitor of IKBKE, and inhibits its downstream targets such as IκBα, p65 and IRF3. Malachite green oxalate exhibits antitumor activity in vitro and in vivo. Malachite green oxalate  Chemical Structure
  29. GN10491 Mangiferin Mangiferin  Chemical Structure
  30. GC17632 Maslinic Acid inhibitor of NO, H2O2 , IL-6 and TNF-α Maslinic Acid  Chemical Structure
  31. GC16607 Mesalamine 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB. Mesalamine  Chemical Structure
  32. GC61043 Mesalamine impurity P Mesalamine impurity P is an impurity of Mesalamine. Mesalamine impurity P  Chemical Structure
  33. GC49241 Methyl Diethyldithiocarbamate An active metabolite of disulfiram Methyl Diethyldithiocarbamate  Chemical Structure
  34. GC16007 Methylthiouracil antithyroid preparation Methylthiouracil  Chemical Structure
  35. GC44238 Mn(III)TBAP

    Mn(III)TBAP is a cell-permeable SOD mimic.

    Mn(III)TBAP  Chemical Structure
  36. GN10436 Morusin Morusin  Chemical Structure
  37. GC17279 N-3-oxo-dodecanoyl-L-Homoserine lactone NF-κB and AP-2 activator N-3-oxo-dodecanoyl-L-Homoserine lactone  Chemical Structure
  38. GC36696 Naringin Dihydrochalcone A flavonoid with antioxidant activity Naringin Dihydrochalcone  Chemical Structure
  39. GC69539 Nasunin

    Nasunin is an antioxidant anthocyanin with anti-angiogenic activity.

    Nasunin  Chemical Structure
  40. GC44353 NDMC101 A salicylanilide derivative NDMC101  Chemical Structure
  41. GN10103 Neferine Neferine  Chemical Structure
  42. GN10429 Neochlorogenic acid Neochlorogenic acid  Chemical Structure
  43. GC60267 Neocryptotanshinone Neocryptotanshinone, a fatty diterpenoids from Salvia Miltiorrhiza, inhibits lipopolysaccharide-induced inflammation by suppression of NF-κB and iNOS signaling pathways. Neocryptotanshinone  Chemical Structure
  44. GC48985 NF-κB Inhibitor (trifluoroacetate salt) A cell-permeable peptide that blocks nuclear import of NF-κB NF-κB Inhibitor (trifluoroacetate salt)  Chemical Structure
  45. GC69555 NF-κB-IN-4

    NF-κB-IN-4 (compound 17) is an effective NF-κB pathway inhibitor that can penetrate the blood-brain barrier. NF-κB-IN-4 exhibits potential low toxicity and anti-neuroinflammatory activity. It can block the activation and phosphorylation of IκBα, reduce the expression of NLRP3, and thus inhibit the activation of NF-κB. NF-κB-IN-4 can be used for research on neuroinflammatory-related diseases.

    NF-κB-IN-4  Chemical Structure
  46. GC69556 NF-κB/MAPK-IN-1

    NF-κB/MAPK-IN-1 (compound 11a) is an effective inhibitor of the NF-κB and MAPK pathways. It has inhibitory effects on NO production, with an IC50 of 6.96 μM. NF-κB/MAPK-IN-1 also inhibits LPS-induced iNOS, COX-2, ERα, and P38 activation. It can inhibit macrophage inflammatory response induced by LPS. NF-κB/MAPK-IN-1 can be used for research on rheumatoid arthritis (RA).

    NF-κB/MAPK-IN-1  Chemical Structure
  47. GC11736 NF-κB Activation Inhibitor III NF-κB Activation Inhibitor III is a potent NF-kB inhibitor that targets downstream of MAPK p38 activation. NF-κB Activation Inhibitor III inhibits TNF-α-induced MMP-9 upregulation. NF-κB Activation Inhibitor III can be used for the research of chemotherapies targeting TNF-α-mediated tumor invasion and metastasis . NF-κB Activation Inhibitor III  Chemical Structure
  48. GC31733 NIK SMI1

    NIK SMI1 is a potent, selective NF-κB inducing kinase (NIK) inhibitor, which inhibits NIK-catalyzed hydrolysis of ATP to ADP with IC50 of 0.23±0.17 nM.

    NIK SMI1  Chemical Structure
  49. GC36794 Okanin Okanin, effective constituent of the flower tea Coreopsis tinctoria, attenuates LPS-induced microglial activation through inhibition of the TLR4/NF-κB signaling pathways. Okanin  Chemical Structure
  50. GC12114 Oxaprozin COX inhibitor Oxaprozin  Chemical Structure
  51. GC49024 Palmitic Acid MaxSpec® Standard A quantitative analytical standard guaranteed to meet MaxSpec® identity, purity, stability, and concentration specifications Palmitic Acid MaxSpec® Standard  Chemical Structure
  52. GC49023 Palmitic Acid-d9 MaxSpec® Standard A quantitative analytical standard guaranteed to meet MaxSpec® identity, purity, stability, and concentration specifications Palmitic Acid-d9 MaxSpec® Standard  Chemical Structure
  53. GN10357 Parthenolide Parthenolide  Chemical Structure
  54. GC60283 Pentagamavunon-1 Pentagamavunon-1 (PGV-1), a Curcumin analog with oral activity, targets on several molecular mechanisms to induce apoptosis including inhibition of angiogenic factors cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF). PGV-1 inhibits NF-κB activation. Pentagamavunon-1  Chemical Structure
  55. GC38170 Phellodendrine Phellodendrine  Chemical Structure
  56. GN10778 Picroside II Picroside II  Chemical Structure
  57. GN10312 Polygalasaponin F Polygalasaponin F  Chemical Structure
  58. GC16657 PPM-18 NF-κB inhibitor PPM-18  Chemical Structure
  59. GC16096 PR 39 (porcine) PR 39 (porcine), a natural proline- and arginine-rich antibacterial peptide, is a noncompetitive, reversible and allosteric proteasome inhibitor. PR 39 (porcine)  Chemical Structure
  60. GC37036 PTD-p65-P1 Peptide PTD-p65-P1 Peptide is a potent, selective nuclear transcription factor NF-κB inhibitor and derives from the p65 subunit of NF-κB amino acid residues 271-282, which selectively inhibits NF-κB activation induced by various inflammatory stimulation, down-regulate NF-κB-mediated gene expression and up-regulate apoptosis. PTD-p65-P1 Peptide  Chemical Structure
  61. GC38520 PTD-p65-P1 Peptide TFA PTD-p65-P1 Peptide TFA is a potent, selective nuclear transcription factor NF-κB inhibitor and derives from the p65 subunit of NF-κB amino acid residues 271-282, which selectively inhibits NF-κB activation induced by various inflammatory stimulation, down-regulate NF-κB-mediated gene expression and up-regulate apoptosis. PTD-p65-P1 Peptide TFA  Chemical Structure
  62. GC49860 Pyropheophorbide a methyl ester Pyropheophorbide a methyl ester (Pyropheophorbide-a methyl ester), a chlorophyll-a derivative, is a potent photosensitizer that can be used in photodynamic therapy (PDT) of cancer. Pyropheophorbide a methyl ester has photodynamic activity and can induce apoptosis and inhibit tumor growth. Pyropheophorbide a methyl ester  Chemical Structure
  63. GC13575 Pyrrolidinedithiocarbamate ammonium A NF-κB inhibitor Pyrrolidinedithiocarbamate ammonium  Chemical Structure
  64. GC11751 QNZ (EVP4593) An inhibitor of NF-κB activation QNZ (EVP4593)  Chemical Structure
  65. GC39428 Quinoclamine Quinoclamine, a naphthoquinone derivative, is a NF-κB inhibitor. Quinoclamine exhibits anti-cancer activity. Quinoclamine  Chemical Structure
  66. GC39081 Reticuline Reticuline shows anti-inflammatory effects through JAK2/STAT3 and NF-κB signaling pathways. Reticuline  Chemical Structure
  67. GN10784 Rhoifolin Rhoifolin  Chemical Structure
  68. GN10185 Rhynchophylline Rhynchophylline  Chemical Structure
  69. GC16874 Ro 106-9920 Inhibitor of NF-κB activation Ro 106-9920  Chemical Structure
  70. GC19548 Rocaglamide

    Rocaglamide is a potent NF-κB activation inhibitor.

    Rocaglamide  Chemical Structure
  71. GC33426 Rocaglamide (Rocaglamide A)

    Rocaglamide (Rocaglamide A) is isolated from the genus Aglaia (family Meliaceae). 

    Rocaglamide (Rocaglamide A)  Chemical Structure
  72. GC60331 Rubiadin-1-methyl ether Rubiadin-1-methyl ether is a natural anthraquinone isolated from Morinda officinalis How, and inhibits osteoclastic bone resorption via inhibition on the phosphorylation of NF-κB p65 and the degradation of IκBα as well as decrease in the nuclear translocation of p65. Rubiadin-1-methyl ether  Chemical Structure
  73. GN10164 Saikosaponin D Saikosaponin D  Chemical Structure
  74. GN10759 Sanggenone C Sanggenone C  Chemical Structure
  75. GN10260 Sarsasapogenin Sarsasapogenin  Chemical Structure
  76. GC10088 SC75741 NF-κB inhibitor, potent SC75741  Chemical Structure
  77. GN10368 Schisantherin A Schisantherin A  Chemical Structure
  78. GC45561 Sciadopitysin   Sciadopitysin  Chemical Structure
  79. GC68141 SEMBL SEMBL  Chemical Structure
  80. GN10216 Shikonin Shikonin  Chemical Structure
  81. GC49002 Sinigrin (hydrate) A glucosinolate with diverse biological activities Sinigrin (hydrate)  Chemical Structure
  82. GN10213 Sinomenine Hydrochloride Sinomenine Hydrochloride  Chemical Structure
  83. GC49049 SMU127 An agonist of TLR1/2 SMU127  Chemical Structure
  84. GC31642 SN50

    SN50, the NF-κB cell permeable inhibitory peptide.

    SN50  Chemical Structure
  85. GC10933 Sodium 4-Aminosalicylate Sodium 4-Aminosalicylate (4-Aminosalicylic acid sodium salt dihydrate) is one of the antimycobacterial drugs currently used for multidrug-resistant tuberculosis. Sodium 4-Aminosalicylate  Chemical Structure
  86. GC12013 Sodium salicylate

    NF-κB inhibitor

    Sodium salicylate  Chemical Structure
  87. GC50139 SP 100030 NF-κB and AP-1 dual inhibitor SP 100030  Chemical Structure
  88. GC37686 Stachydrine Stachydrine is a major constituent of Chinese herb leonurus heterophyllus sweet used to promote blood circulation and dispel blood stasis. Stachydrine  Chemical Structure
  89. GC13840 Stachydrine (hydrochloride) anti-metastatic agent Stachydrine (hydrochloride)  Chemical Structure
  90. GC49844 Stercobilin (hydrochloride) A fecal pigment and metabolite of bilirubin Stercobilin (hydrochloride)  Chemical Structure
  91. GC11819 Strontium Ranelate Calcium Channel activator Strontium Ranelate  Chemical Structure
  92. GC38984 Suberosin Suberosin, isolated from Plumbago zeylanica, exhibits anti-inflammatory and anticoagulant activity. Suberosin  Chemical Structure
  93. GC16868 Sulfasalazine NF-κB activation inhibitor Sulfasalazine  Chemical Structure
  94. GC32737 TAK-243 (MLN7243) TAK-243 (MLN7243) (MLN7243) is a first-in-class, selective ubiquitin activating enzyme, UAE (UBA1) inhibitor (IC50=1 nM), which blocks ubiquitin conjugation, disrupting monoubiquitin signaling as well as global protein ubiquitination. TAK-243 (MLN7243) (MLN7243) induces endoplasmic reticulum (ER) stress, abrogates NF-κB pathway activation and promotes apoptosis. TAK-243 (MLN7243)  Chemical Structure
  95. GC60352 Taraxerol

    Taraxerol has anti-inflammatory and anticancer effects.

    Taraxerol  Chemical Structure
  96. GC34171 Tectochrysin (Techtochrysin) Tectochrysin (Techtochrysin) (Techtochrysin) is one of the major flavonoids of Alpinia oxyphylla Miquel. Tectochrysin (Techtochrysin) inhibits activity of NF-κB. Tectochrysin (Techtochrysin)  Chemical Structure
  97. GC41573 Theaflavin 3,3'-digallate

    Theaflavin-3,3'-digallate (TFDG) is a major polyphenol found in black tea with diverse biological activities.

    Theaflavin 3,3'-digallate  Chemical Structure
  98. GC31647 Tomatidine Tomatidine acts as an anti-inflammatory agent by blocking NF-κB and JNK signaling. Tomatidine  Chemical Structure
  99. GC45064 Tomatidine (hydrochloride) Tomatidine is a steroidal alkaloid that has been found in the skins and leaves of tomatoes. Tomatidine (hydrochloride)  Chemical Structure
  100. GC38868 TRAF-STOP inhibitor 6877002 TRAF-STOP inhibitor 6877002, is a selective inhibitor of CD40-TRAF6 interaction, compound VII, shows inhibition of NF-κB activation in RAW cells, extracted from patent WO2014033122A1. TRAF-STOP inhibitor 6877002  Chemical Structure
  101. GC48202 Treprostinil (diethanolamine salt) Treprostinil (UT-15C) diethanolamine is a potent EP2, DP1 and IP agonist with Ki values of 3.6, 4.4, 32.1, 212, 826, 2505 and 4680 nM for EP2, DP1, IP, EP1, EP4, EP3 and FP, respectively. Treprostinil (diethanolamine salt)  Chemical Structure

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