GLPBio

NF-κB

NF-κB is a family of conserved and ubiquitous transcription factors that involved in various biological processes including immunity, inflammation, cell growth, differentiation and apoptosis. It is associated with cancer, chronic inflammation and arthritis etc.

Products Related to NF-κB(335)

  • GC84086 structure
    GC84086SjDX5-271
    CAS: 2767993-76-8
    Purity: >98.50%

    SjDX5-271 is a small 3 kDa peptide.

  • GC84117 structure
    GC84117SPA0355
    CAS: 1251839-15-2
    Purity: >99.50%

    SPA0355 is a thiourea derivative that has antioxidant and anti-inflammatory properties.

  • GC84264 structure
    GC84264TLR4/NF-κB-IN-1
    CAS: 3050836-94-4
    Purity: >99.50%

    TLR4/NF-κB-IN-1 (Compound 7x) is an orally available inhibitor that specifically targets the TLR4/NF-κB signaling pathway, offering anti-inflammatory effects and the ability to cross the blood-brain barrier.

  • GC84265 structure
    GC84265TLR8 antagonist-1
    CAS: 1111460-83-3
    Purity: >99.50%

    TLR8 antagonist-1 (Compound 10) is a selective TLR8 antagonist.

  • GC84273 structure
    GC84273TNF-α (31-45), human TFA
    Purity: >99.00%

    TNF-α (31-45), human TFA is a potent NF-kB pathway activator.

  • GC84278 structure
    GC84278Tofacitinib- 13 C 3 , 15 N
    Purity: >99.50%

    Tofacitinib - 13 C 3, 15 N (Tasocitinib- 13 C 3, 15 N; CP-690550- 13 C 3, 15 N) is the 15 N, 13 C-labeled Tofacitinib.

  • GC84309 structure
    GC84309Triptolide-d 3
    Purity: >91.50%

    Triptolide-d 3 is the deuterium labeled Triptolide.

  • GC84591 structure
    GC84591Anti-Mouse RANKL/CD254 Antibody (IK22/5)
    Purity: >99.00%

    Anti-Mouse RANKL/CD254 Antibody (IK22/5) is an anti-mouse RANKL/CD254 IgG2a monoclonal antibody.

  • GC84674 structure
    GC84674IKKγ NBD Inhibitory Peptide TFA
    Purity: >98.50%

    IKKγ NBD Inhibitory Peptide TFA is a highly specific inhibitor NF-κB inhibitor.

  • GC84770 structure
    GC84770Sappanone A
    CAS: 102067-84-5
    Purity: >99.50%

    Sappanone A is an orally active homoisoflavone found in sappan L.

  • GC84789 structure
    GC84789(+)-Magnoflorine iodide
    CAS: 4277-43-4
    Purity: >99.50%

    (+)-Magnoflorine (α-Magnoflorine) iodide is an orally active aporphine alkaloid with multiple biological activities.

  • GC84872 structure
    GC84872NF-κB-IN-4
    CAS: 3033258-60-2
    Purity: >98.50%

    NF-κB-IN-4 (compound 17) is a potent NF-κB pathway inhibitor with blood brain barrier (BBB) permeability.

  • GB57663 structure
    GB57663Chitin
    CAS: 1398-61-4

    Chitin is a variety of sugars extracted from the shells of marine crustaceans and is widely found in shrimp and crabs in nature.

  • GC10130 structure
    GC10130Chicago Sky Blue 6B
    CAS: 2610-05-1
    Purity: >97.50%

    Chicago Sky Blue 6B is a counterstain for background autofluorescence in fluorescence and immunofluorescence histochemistry. Chicago Sky Blue 6B is a potent competitive inhibitor of vesicular glutamate transporter 1 (VGLUT1) with an IC 50 of 3μM.

  • GC10345 structure
    GC10345Bay 11-7085
    CAS: 196309-76-9
    Purity: >99.00%

    Bay 11-7085 is an inhibitor of NF-κB activation and phosphorylation of IκBα with an IC 50 value of 10μM for IκBα.

  • GC10474 structure
    GC10474Laquinimod (ABR-215062)
    CAS: 248281-84-7
    Purity: >98.00%

    Laquinimod (ABR-215062) (ABR-215062), an orally available carboxamide derivative, is a potent immunomodulator which prevents neurodegeneration and inflammation in the central nervous system.

  • GC10480 structure
    GC10480Betulinic acid
    CAS: 472-15-1
    Purity: >98.00%

    Betulinic acid is a natural pentacyclic triterpenoid compound and an inhibitor of eukaryotic topoisomerase I with an IC 50 value of 5 μM.

  • GC10519 structure
    GC10519Ethacrynic acid - d5
    CAS: 1330052-59-9
    Purity: >98.00%

    Used as an internal standard for GC- or LC-mass spectrometry

  • GC10821 structure
    GC1082111-keto-β-Boswellic Acid
    CAS: 17019-92-0
    Purity: >99.50%

    11-Keto-beta-boswellic acid (11-Keto-β-boswellic acid) is a pentacyclic triterpenic acid of the oleogum resin from the bark of the Boswellia serrate tree, popularly known as Indian Frankincense. 11-Keto-beta-boswellic acid has the anti-inflammatory activity is primarily due to inhibit 5-lipoxygenase (5-LOX) and subsequent leukotriene and nuclear factor-kappa B (NF-κB) activation and tumor necrosis factor alpha generation production.

  • GC11736 structure
    GC11736NF-κB Activation Inhibitor III
    CAS: 380623-76-7
    Purity: >98.00%

    NF-κB Activation Inhibitor III is a potent NF-kB inhibitor that targets downstream of MAPK p38 activation. NF-κB Activation Inhibitor III inhibits TNF-α-induced MMP-9 upregulation. NF-κB Activation Inhibitor III can be used for the research of chemotherapies targeting TNF-α-mediated tumor invasion and metastasis .

  • GC11751 structure
    GC11751QNZ (EVP4593)
    CAS: 545380-34-5
    Purity: >98.00%

    QNZ (EVP4593) is a highly potent and selective inhibitor of the nuclear factor κB (NF-κB) signaling pathway with an IC 50 value of 11nM and has anti-inflammatory effects.

  • GC12114 structure
    GC12114Oxaprozin
    CAS: 21256-18-8
    Purity: >99.50%

    COX inhibitor

  • GC12532 structure
    GC12532CHPG
    CAS: 170846-74-9
    Purity: >98.00%

    CHPG is a selective metabotropic glutamate receptor 5 (mGlu5) agonist.

  • GC13030 structure
    GC13030(R)-(-)-Ibuprofen
    CAS: 51146-57-7
    Purity: >99.50%

    Inhibitor of Cox-1 and Cox-2