Licoricidin |
Catalog No.GC36456
One-Click Copy Product Info
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Licoricidin is an isoflavonoid compound isolated from Glycyrrhiza uralensis Fisch, possessing various biological activities such as anticancer, antibacterial, and anti-inflammatory effects.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 30508-27-1
Sample solution is provided at 25 µL, 10mM.
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Licoricidin is an isoflavonoid compound isolated from Glycyrrhiza uralensis Fisch, possessing various biological activities such as anticancer, antibacterial, and anti-inflammatory effects. Licoricidin exerts its anticancer effects by inducing cell cycle arrest, apoptosis, and autophagy, as well as inhibiting tumor angiogenesis and lymphangiogenesis. Licoricidin can be used in research on cancers such as colorectal cancer, gastric cancer, and prostate cancer, as well as in studies related to antibacterial and anti-photoaging activities[1-4].
In vitro, 4T1 murine mammary carcinoma cells were treated with Licoricidin (0–5μg/ml) for 18 hours. Licoricidin significantly inhibited cell migration, MMP-9 secretion, and VCAM expression[5]. Human cervical cancer HeLa, C-33A, and SiHa cells were treated with Licoricidin (20μM) for 24 hours. Licoricidin increased the proportion of apoptotic cells in C-33A and SiHa cells; combined treatment with paclitaxel (10μM) further inhibited the growth of C-33A and HeLa cells, induced apoptosis, and triggered endoplasmic reticulum stress[6].
In vivo, Licoricidin (1mg/mouse; administered orally 5 days per week) was given to atopic dermatitis mouse models induced by dinitrochlorobenzene and/or house dust mite extract for 4 consecutive weeks. Licoricidin significantly alleviated atopic dermatitis symptoms, including reduced ear thickness, serum IgE levels, dermal and epidermal thickness, immune cell infiltration, and decreased mRNA levels of pro-inflammatory cytokines[7]. Licoricidin (10mg/kg and 20mg/kg; administered intraperitoneally every 2 days) was injected into BALB/c-Nu nude mice bearing MGC-803 gastric cancer cell xenograft tumors for 18 days. Licoricidin significantly inhibited tumor growth[8].
References:
[1] Ji S, Tang S, Li K, et al. Licoricidin inhibits the growth of SW480 human colorectal adenocarcinoma cells in vitro and in vivo by inducing cycle arrest, apoptosis and autophagy. Toxicol Appl Pharmacol. 2017 Jul 1;326:25-33.
[2] Wang Y, Wang S, Liu J, et al. Licoricidin enhances gemcitabine-induced cytotoxicity in osteosarcoma cells by suppressing the Akt and NF-κB signal pathways. Chem Biol Interact. 2018 Jun 25;290:44-51.
[3] Kim KJ, Xuan SH, Park SN. Licoricidin, an isoflavonoid isolated from Glycyrrhiza uralensis Fisher, prevents UVA-induced photoaging of human dermal fibroblasts. Int J Cosmet Sci. 2017 Apr;39(2):133-140.
[4] Liu C, He D, Zhao Q. Licoricidin improves neurological dysfunction after traumatic brain injury in mice via regulating FoxO3/Wnt/β-catenin pathway. J Nat Med. 2020 Sep;74(4):767-776.
[5] Park SY, Kwon SJ, Lim SS, et al. Licoricidin, an Active Compound in the Hexane/Ethanol Extract of Glycyrrhiza uralensis, Inhibits Lung Metastasis of 4T1 Murine Mammary Carcinoma Cells. Int J Mol Sci. 2016 Jun 14;17(6):934.
[6] Tai CT, Chen YC, Hsieh YH, et al. Licoricidin Enhances Paclitaxel-induced Apoptosis Through Endoplasmic Reticulum Stress in Human Cervical Cancer Cells. In Vivo. 2025 Nov-Dec;39(6):3195-3204.
[7] Lee HS, Kim J, Choi HG, et al. Licoricidin Abrogates T-Cell Activation by Modulating PTPN1 Activity and Attenuates Atopic Dermatitis In Vivo. J Invest Dermatol. 2021 Oct;141(10):2490-2498.e6.
[8] Ma H, Wu F, Bai Y, et al. Licoricidin combats gastric cancer by targeting the ICMT/Ras pathway in vitro and in vivo. Front Pharmacol. 2022 Oct 13;13:972825.
| Cell experiment [1]: | |
Cell lines | 4T1 murine mammary carcinoma cells |
Preparation Method | 4T1 cells were cultured in DMEM containing 10% FBS, penicillin, and streptomycin. Cells were treated with Licoricidin. |
Reaction Conditions | 0-5μg/mL; 24h |
Applications | Licoricidin inhibited the migration of 4T1 cells. Licoricidin treatment reduced the levels of MMP-9 and VCAM-1 in 4T1 cells. |
| Animal experiment [2]: | |
Animal models | BALB/c mice (female, 8 weeks old) |
Preparation Method | Mice were induced with atopic dermatitis (AD) by applying dinitrochlorobenzene (DNCB) and/or house dust mite extract to the ears, followed by oral administration of Licoricidin for 4 weeks. |
Dosage form | 1mg/mice; oral administration; five days a week for 4 weeks |
Applications | Licoricidin significantly attenuated AD symptoms, including reduced ear thickness, decreased serum IgE levels, thinner dermal and epidermal tissues, diminished infiltration of immune cells (e.g., mast cells), and downregulated mRNA levels of proinflammatory cytokines (IL-4, IL-5, IL-6, IL-13) in ear lesions. |
References: | |
| Cas No. | 30508-27-1 | SDF | |
| Canonical SMILES | COC1=C2C(OC[C@@H](C3=C(C(C/C=C(C)/C)=C(O)C=C3)O)C2)=CC(O)=C1C/C=C(C)/C | ||
| Formula | C26H32O5 | M.Wt | 424.53 |
| Solubility | Soluble in DMSO | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 2.3555 mL | 11.7777 mL | 23.5555 mL |
| 5 mM | 471.1 μL | 2.3555 mL | 4.7111 mL |
| 10 mM | 235.6 μL | 1.1778 mL | 2.3555 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 4 reference(s) in Google Scholar.)