Ferroptosis

ROS-generating agent 1 (Compound 2c) covalently modifies the Sec-498 residue of TrxR to generate ROS.

Tubulin inhibitor 30 (Compound 15) is a tubulin assembly inhibitor with an IC50 of 0.52 μM.

W1131 TFA is a potent STAT3 inhibitor that induces ferroptosis.

GPX4-IN-6 (Compound C25) is a GPX4 covalent inhibitor with an IC50 value of 0.13 μM.

TfR-1-IN-1 (compound C4) is an inhibitor of transferrin receptor 1 (TfR-1) with anticancer activity.

Ferroptosis-IN-6 (compound 13) is a potent inhibitor of Ferroptosis with EC50 of 25.5 nM.

Butylated droxytoluene-d3 is the deuterium labeled Butylated droxytoluene.

2',4-Dihydroxychalcone is an orally active natural chalcone flavonoid.

NFE2L1 activator-1 (Compound 5b) is a potent nuclear factor erythroid 2-related factor 1 ( NFE2L1 ) activator ( EC 50 = 2.4 µM).

Ferfluor-1 is a Ferroptosis inhibitor ( EC 50 of 57 nM in HT108 cells; EC 50 of 75 nM in OS-RC-2 cells; EC 50 of 2.3 nM in SH-SY5Y neuroblastoma cells), and ratiometric photoluminescent probe with blood-brain barrier permeability.

RhoNox-4 is a ferroptosis inhibitor and a fluorescence activation indicator specific to Fe 2+. RhoNox-4 selectively reacts with labile Fe 2+ and oxidizes it to Fe 3+, depleting labile Fe 2+ involved in lipid peroxidation and inhibiting ferroptosis induced by ferroptosis inducers.

LPd peroxida probe-2 (Compound I-1) is a lipid peroxidation fluorescent indicator (Ex = 488 nm, Em = 535 nm).

3-Hydroxyindole is a hydroxyindole compound.

SZ0232 is a selective mPGES-2 inhibitor.

RSL3-NH2 hydrochloride is a GPX4 inhibitor and ferroptosis inducer.

GPX4-IN-19 is an effective GPX4 inhibitor ( IC 50 = 0.311 μM), covalently binds to the Sec 46 site of GPX4.

Ferroptosis inducer-12 is a potent and selective ferroptosis inducer.

iMQT_020 is a selective allosteric SLC1A5_var inhibitor.

ZIP 14-IN-1 (PPTD) is a selective and orally active ZIP14 inhibitor.

Nrf2-IN-4 (Compound PhcY) hydrobromide is a Nrf2 inhibitor.

2-Acetamidophenol -d 3 (Orthocetamol-d 3 ) is the deuterium labeled 2-Acetamidophenol.

PROTAC GPX4 degrader-5 (compound N15) is an efficient and highly selective PROTAC GPX4 degrader ( DC 50 = 28 nM).

DIM-3,5-Cl2 is an inverse NR4A1/NR4A2 agonist with K D values of 7.7 μM and 12.0 μM for NR4A1 and NR4A2, respectively.

HDAC11-IN-5 is a selective, potent and orally active HDAC11 inhibitor with an IC 50 of 0.021 μM.