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Ferroptosis

Ferroptosis is a unique iron-dependent form of nonapoptotic cell death. It is triggered by oncogenic RAS-selective lethal small molecule erastin. Acitvation of ferroptosis lead to nonapoptotic destruction of cancer cells.

Products for  Ferroptosis

  1. Cat.No. Product Name Information
  2. GC14049 (-)-Epigallocatechin gallate (EGCG) Antioxidant, antiangiogenic and antitumor agent (-)-Epigallocatechin gallate (EGCG)  Chemical Structure
  3. GC45248 (-)-FINO2 (-)-FINO2 is a ferroptosis-inducing peroxide compound that indirectly inhibits glutathione peroxidase 4 (GPX4) and oxidizes iron. (-)-FINO2  Chemical Structure
  4. GA11210 (H-Cys-OH)2 (H-Cys-OH)2 (H-Cys-OH)2  Chemical Structure
  5. GC42039 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PC 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PC is a phospholipid that contains stearic acid at the sn-1 position and 15(S)-HETE at the sn-2 position. 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PC  Chemical Structure
  6. GC42040 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE is a phospholipid that contains stearic acid at the sn-1 position and 15(S)-HETE at the sn-2 position. 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE  Chemical Structure
  7. GC49730 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE-d11 An internal standard for the quantification of 1-stearoyl-2-15(S)-HETE-sn-glycero-3-PE 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE-d11  Chemical Structure
  8. GC42041 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PC 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PC is a phospholipid that contains stearic acid at the sn-1 position and 15(S)-HpETE at the sn-2 position. 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PC  Chemical Structure
  9. GC42042 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PE 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PE is a phospholipid that contains stearic acid at the sn-1 position and 15(S)-HpETE at the sn-2 position. 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PE  Chemical Structure
  10. GC11786 Acetylcysteine Antioxidant;Mucolytic agent Acetylcysteine  Chemical Structure
  11. GC15130 Alogliptin (SYR-322)

    DPP-4 inhibitor,potent and highly selective

    Alogliptin (SYR-322)  Chemical Structure
  12. GC61895 Ammonium iron(III) citrate Ammonium iron(III) citrate  Chemical Structure
  13. GC65163 Ardisiacrispin B Ardisiacrispin B  Chemical Structure
  14. GC35399 Artefenomel Artefenomel  Chemical Structure
  15. GN10647 Artemisinine Extracted from Artemisia annua L.;Suitability:Acetone,benzene,chloroform,ethyl acetate and acetic acid;Store the product in sealed,cool and dry condition Artemisinine  Chemical Structure
  16. GC10889 Artesunate Derivative of the natural product artemisinin Artesunate  Chemical Structure
  17. GC14038 Atorvastatin Calcium HMG-CoA reductase inhibitor Atorvastatin Calcium  Chemical Structure
  18. GN10158 Baicalein Lipoxygenases inhibitor Baicalein  Chemical Structure
  19. GC11572 Bardoxolone methyl

    IKK inhibitor, potent antioxidant inflammation modulator

    Bardoxolone methyl  Chemical Structure
  20. GC10345 Bay 11-7085

    NK-κB activation inhibitor

    Bay 11-7085  Chemical Structure
  21. GC12698 BAY 87-2243 A HIF-1 inhibitor,potent and selective BAY 87-2243  Chemical Structure
  22. GC42928 BHT BHT is a widely used synthetic antioxidant found in all types of manufactured items, from foodstuffs, to cosmetics, to rubber, and paint. BHT  Chemical Structure
  23. GC34070 Brusatol (NSC 172924)

    A quassinoid with diverse biological activities

    Brusatol (NSC 172924)  Chemical Structure
  24. GC30067 Butylhydroxyanisole (Butylated hydroxyanisole) Butylhydroxyanisole (Butylated hydroxyanisole)  Chemical Structure
  25. GC32723 CDDO-Im (RTA-403) CDDO-Im (RTA-403)  Chemical Structure
  26. GC43231 Cerivastatin (sodium salt) Cerivastatin is an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase (Ki = 1.3 nM). Cerivastatin (sodium salt)  Chemical Structure
  27. GC45792 Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III) Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III)  Chemical Structure
  28. GC10132 Ciclopirox broad-spectrum antifungal agent Ciclopirox  Chemical Structure
  29. GC11120 Ciclopirox ethanolamine iron chelator, broad-spectrum antifungal agent Ciclopirox ethanolamine  Chemical Structure
  30. GC32237 CIL56 CIL56  Chemical Structure
  31. GC11908 Cisplatin

    Cisplatin is one of the best and first metal-based chemotherapeutic drugs, which is used for wide range of solid cancers such as testicular, ovarian, bladder, lung, cervical, head and neck cancer, gastric cancer and some other cancers.

    Cisplatin  Chemical Structure
  32. GN10668 Coenzyme Q10 Extracted from Coenzyme Q10;Suitability:Chloroform,benzene and carbon tetrachloride;Store the product in sealed,cool and dry condition Coenzyme Q10  Chemical Structure
  33. GC43297 Coenzyme Q2 Coenzyme Q10 is a component of the electron transport chain and participates in aerobic cellular respiration, generating energy in the form of ATP. Coenzyme Q2  Chemical Structure
  34. GC49454 Complex 3 A fluorescent copper complex with anticancer activity Complex 3  Chemical Structure
  35. GC43329 Cu-ATSM The metallo-protein Cu/Zn-superoxide dismutase (SOD1) is a ubiquitous enzyme responsible for scavenging superoxide radicals. Cu-ATSM  Chemical Structure
  36. GC52164 Cu-ATSP Cu-ATSP  Chemical Structure
  37. GC14787 Curcumin A tyrosinase inhibitor Curcumin  Chemical Structure
  38. GC40226 Curcumin-d6 Curcumin-d6 is intended for use as an internal standard for the quantification of curcumin by GC- or LC-MS. Curcumin-d6  Chemical Structure
  39. GC10896 Cyclic Pifithrin-α hydrobromide P53 inhibitor Cyclic Pifithrin-α hydrobromide  Chemical Structure
  40. GC17198 Cycloheximide

    Cycloheximide is an antibiotic that inhibits protein synthesis at the translation level

    Cycloheximide  Chemical Structure
  41. GC33023 D,L-Buthionine-(S,R)-sulfoximine (Butionine sulfoximine) D,L-Buthionine-(S,R)-sulfoximine (Butionine sulfoximine)  Chemical Structure
  42. GC35795 D,L-Buthionine-(S,R)-sulfoximine hydrochloride D,L-Buthionine-(S,R)-sulfoximine hydrochloride  Chemical Structure
  43. GC11835 Deferasirox

    Oral iron chelator

    Deferasirox  Chemical Structure
  44. GC17412 Deferasirox Fe3+ chelate Oral iron chelator Deferasirox Fe3+ chelate  Chemical Structure
  45. GC18101 Deferiprone Chelating agent Deferiprone  Chemical Structure
  46. GC13554 Deferoxamine mesylate

    Deferoxamine mesylate is a drug that chelates iron by forming a stable complex that prevents the iron from entering into further chemical reactions, and is used for the treatment of chronic iron overload in patients with transfusion-dependent anemias.

    Deferoxamine mesylate  Chemical Structure
  47. GC38429 Dihydroartemisinic acid Dihydroartemisinic acid  Chemical Structure
  48. GC35876 DL-Glutamine DL-Glutamine  Chemical Structure
  49. GC45995 DO264 DO264  Chemical Structure
  50. GC31940 Docebenone (AA 861) Docebenone (AA 861)  Chemical Structure
  51. GC15399 Dp44mT iron chelator and anticancer agent Dp44mT  Chemical Structure
  52. GC10331 Ebselen Ebselen  Chemical Structure
  53. GC16630 Erastin

    Erastin is a cell-permeable ferroptosis activatior and antitumor agent.

    Erastin  Chemical Structure
  54. GC43623 Erastin2 A ferroptosis inducer Erastin2  Chemical Structure
  55. GC36011 Ethylenediaminetetraacetic acid trisodium salt Ethylenediaminetetraacetic acid trisodium salt  Chemical Structure
  56. GC16517 Eugenol naturally occuring scent chemical Eugenol  Chemical Structure
  57. GC10380 Ferrostatin-1 (Fer-1)

    Ferrostatin-1 is a potent inhibitor of ferroptosis with an EC50 of 60 nM.

    Ferrostatin-1 (Fer-1)  Chemical Structure
  58. GC40211 Ferrostatin-1 Diyne Ferrostatin-1 diyne is a ferroptosis inhibitor and analog of ferrostatin-1. Ferrostatin-1 Diyne  Chemical Structure
  59. GC13139 FG-4592 (ASP1517)

    FG-4592, as an oral bioavailable hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitor, can promote coordinated erythropoiesis through HIF-mediated transcription.

    FG-4592 (ASP1517)  Chemical Structure
  60. GC30039 FIN56 FIN56  Chemical Structure
  61. GC15541 Fluvastatin Sodium HMG-CoA reductase inhibitor Fluvastatin Sodium  Chemical Structure
  62. GN10388 Gallic acid Gallic acid is found in almost all plants. Plants known for their high gallic acid content include gallnuts,grapes,tea,hops and oak bark. Gallic acid  Chemical Structure
  63. GC61436 Gallic acid hydrate Gallic acid hydrate  Chemical Structure
  64. GC11882 GKT137831 dual NADPH oxidase Nox1/Nox4 inhibitor GKT137831  Chemical Structure
  65. GC41293 Glutathione ethyl ester

    Glutathione (GSH) serves as a nucleophilic co-substrate to glutathione transferase in the detoxification of xenobiotics and is an essential electron donor to glutathione peroxidases in the reduction of hydroperoxides.

    Glutathione ethyl ester  Chemical Structure
  66. GC49697 GPX4 Inhibitor 26a A GPX4 inhibitor GPX4 Inhibitor 26a  Chemical Structure
  67. GA11257 H-Cys-OH H-Cys-OH H-Cys-OH  Chemical Structure
  68. GA10942 H-D-Gln-OH H-D-Gln-OH H-D-Gln-OH  Chemical Structure
  69. GA10750 H-Glu-OH H-Glu-OH H-Glu-OH  Chemical Structure
  70. GC14591 Hemin chloride eukaryotic translation initiation factor 2α kinase 1 (eIF2αK1) inhibitor Hemin chloride  Chemical Structure
  71. GC15972 Idebenone synthetic analog of coenzyme Q10 (CoQ10) Idebenone  Chemical Structure
  72. GC45928 iFSP1 iFSP1  Chemical Structure
  73. GC45793 IM-93 IM-93  Chemical Structure
  74. GC52190 Imidazole Ketone Erastin Imidazole Ketone Erastin  Chemical Structure
  75. GC33098 L-Buthionine-(S,R)-sulfoximine (L-Butionine sulfoximine) L-Buthionine-(S,R)-sulfoximine (L-Butionine sulfoximine)  Chemical Structure
  76. GC62643 L-Buthionine-(S,R)-sulfoximine hydrochloride L-Buthionine-(S,R)-sulfoximine hydrochloride  Chemical Structure
  77. GC30788 L-Glutamic acid monosodium salt (Monosodium glutamate) L-Glutamic acid monosodium salt (Monosodium glutamate)  Chemical Structure
  78. GC64352 L-Glutamic acid-15N L-Glutamic acid-15N  Chemical Structure
  79. GC65095 L-Glutamic acid-d5 L-Glutamic acid-d5  Chemical Structure
  80. GC17498 L-Glutamine Non-essential amino acid L-Glutamine  Chemical Structure
  81. GC65068 L-Glutamine 15N L-Glutamine 15N  Chemical Structure
  82. GC12203 L-Glutathione Reduced Used to elute GST from glutathione agarose L-Glutathione Reduced  Chemical Structure
  83. GC49560 L6H21 An inhibitor of the MD-2 and TLR4 interaction L6H21  Chemical Structure
  84. GC13608 Lapatinib

    EGFR/HER2 inhibitor,potent,selective and reversible

    Lapatinib  Chemical Structure
  85. GC16593 Lapatinib Ditosylate EGFR/HER2 inhibitor, potent and selective Lapatinib Ditosylate  Chemical Structure
  86. GC14827 Linagliptin (BI-1356) DDP-4 inhibitor,highly potent and competitive Linagliptin (BI-1356)  Chemical Structure
  87. GC15681 Liproxstatin-1

    Liproxstatin-1 is a potent inhibitor of ferroptosis and can protect against ferroptosis-inducing agents, such as buthionine sulfoxamine (BSO), erastin, and (1S,3R)-RSL3 (RSL3).

    Liproxstatin-1  Chemical Structure
  88. GC50345 Liproxstatin-1 hydrochloride Potent ferroptosis inhibitor Liproxstatin-1 hydrochloride  Chemical Structure
  89. GC11633 Lovastatin

    HMG-CoA reductase inhibitor

    Lovastatin  Chemical Structure
  90. GC44214 ML-162

    ML-162 is a GPX4 inhibitor that is selectively lethal to mutant RAS oncogene-expressing cell lines (IC50s = 25 and 578 nM for HRASG12V-expressing and wild-type BJ fibroblasts, respectively).

    ML-162  Chemical Structure
  91. GC18705 ML-210

    A GPX4 inhibitor

    ML-210  Chemical Structure
  92. GC19254 ML385

    ML385 is a specific nuclear factor erythroid 2-related factor 2 (NRF2) inhibitor.

    ML385  Chemical Structure
  93. GC33469 NADPH tetracyclohexanamine NADPH tetracyclohexanamine  Chemical Structure
  94. GC34058 NADPH tetrasodium salt NADPH tetrasodium salt  Chemical Structure
  95. GC11008 Necrostatin-1

    A RIP1 inhibitor

    Necrostatin-1  Chemical Structure
  96. GC18089 Nordihydroguaiaretic acid Anti-tumor agent;lipoxygenase inhibitor Nordihydroguaiaretic acid  Chemical Structure
  97. GC12205 PD 146176 15-lipoxygenase (15-LOX) inhibitor PD 146176  Chemical Structure
  98. GC10538 Pifithrin-α (PFTα) p53 inhibitor Pifithrin-α (PFTα)  Chemical Structure
  99. GC14948 Pioglitazone PPAR agonist Pioglitazone  Chemical Structure
  100. GC61187 Pioglitazone D4 Pioglitazone D4  Chemical Structure
  101. GC11152 Pioglitazone HCl PPARγ agonist Pioglitazone HCl  Chemical Structure

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