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Home >> Signaling Pathways >> Metabolism >> Ferroptosis

Ferroptosis

Ferroptosis is a unique iron-dependent form of nonapoptotic cell death. It is triggered by oncogenic RAS-selective lethal small molecule erastin. Acitvation of ferroptosis lead to nonapoptotic destruction of cancer cells.

Products for  Ferroptosis

  1. Cat.No. Product Name Information
  2. GC14049 (-)-Epigallocatechin gallate (EGCG)

    EGCG

     (-)-Epigallocatechin Gallate sulfate (EGCG) is a major polyphenol in green tea that inhibits cell proliferation and induces apoptosis. (-)-Epigallocatechin gallate (EGCG) Chemical Structure
  3. GC45248 (-)-FINO2 (-)-FINO2 is a ferroptosis-inducing peroxide compound that indirectly inhibits glutathione peroxidase 4 (GPX4) and oxidizes iron. (-)-FINO2 Chemical Structure
  4. GC34980 (E)-Ferulic acid (E)-Ferulic acid is a isomer of Ferulic acid which is an aromatic compound, abundant in plant cell walls. (E)-Ferulic acid causes the phosphorylation of β-catenin, resulting in proteasomal degradation of β-catenin and increases the expression of pro-apoptotic factor Bax and decreases the expression of pro-survival factor survivin. (E)-Ferulic acid shows a potent ability to remove reactive oxygen species (ROS) and inhibits lipid peroxidation. (E)-Ferulic acid exerts both anti-proliferation and anti-migration effects in the human lung cancer cell line H1299. (E)-Ferulic acid Chemical Structure
  5. GA11210 (H-Cys-OH)2

    (-)-Cystine, NSC 13203

     (H-Cys-OH)2 Chemical Structure
  6. GC52290 (R)-HTS-3 An inhibitor of LPCAT3 (R)-HTS-3 Chemical Structure
  7. GC46352 (S)-DO271 An inactive control for DO264 (S)-DO271 Chemical Structure
  8. GC49034 1(R)-(Trifluoromethyl)oleyl alcohol An oleic acid analog 1(R)-(Trifluoromethyl)oleyl alcohol Chemical Structure
  9. GC42039 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PC

    15(S)-HETE-SAPC, 15(S)-Hydroxyeicostetraenoic Acid-SAPC, 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-Phosphatidylcholine

     1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PC is a phospholipid that contains stearic acid at the sn-1 position and 15(S)-HETE at the sn-2 position. 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PC Chemical Structure
  10. GC42040 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE

    15(S)-HETE-SAPE, 15(S)-Hydroxyeicosatetraenoic Acid-SAPE, 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-Phosphatidylethanolamine

     1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE is a phospholipid that contains stearic acid at the sn-1 position and 15(S)-HETE at the sn-2 position. 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE Chemical Structure
  11. GC49730 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE-d11

    15(S)-HETE-SAPE-d11, 15(S)-Hydroxyeicosatetraenoic Acid-SAPE-d11, 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-Phosphatidylethanolamine-d11

     An internal standard for the quantification of 1-stearoyl-2-15(S)-HETE-sn-glycero-3-PE 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE-d11 Chemical Structure
  12. GC42041 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PC

    15(S)-HpETE-SAPC, 15(S)-Hydroperoxyeicostetraenoic Acid-SAPC, 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-Phosphatidylcholine

     1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PC is a phospholipid that contains stearic acid at the sn-1 position and 15(S)-HpETE at the sn-2 position. 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PC Chemical Structure
  13. GC42042 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PE

    1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-phosphoethanolamine, 15(S)-HpETE-SAPE, 15(S)-hydroperoxyeicostetraenoic acid-SAPE

     1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PE is a phospholipid that contains stearic acid at the sn-1 position and 15(S)-HpETE at the sn-2 position. 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PE Chemical Structure
  14. GC62033 3α-Hydroxy pravastatin sodium

    3α-Isopravastatin, R-416

     3α-Hydroxy pravastatin sodium is the major metabolite of Pravastatin. 3α-Hydroxy pravastatin sodium Chemical Structure
  15. GC52413 5-Aminosalicylic Acid-d7

    5-ASA-d7, Mesalamine-d7, Mesalazine-d7

     An internal standard for the quantification of 5-aminosalicylic acid 5-Aminosalicylic Acid-d7 Chemical Structure
  16. GC68580 84-B10

    84-B10 is a derivative of 3-phenylpentanedioic acid. It inhibits cisplatin-induced renal tubular iron death. 84-B10 alleviates mitochondrial damage and oxidative stress induced by cisplatin. 84-B10 improves acute kidney injury (AKI) induced by cisplatin.

     84-B10 Chemical Structure
  17. GC11786 Acetylcysteine

    N-acetylcysteine; N-acetyl-L-cysteine; NAC; Acetadote

     Acetylcysteine is the N-acetyl derivative of CYSTEINE. Acetylcysteine Chemical Structure
  18. GC15130 Alogliptin (SYR-322) Alogliptin (SYR-322) Chemical Structure
  19. GC61895 Ammonium iron(III) citrate Ammonium iron(III) citrate (Ammonium ferric citrate), a physiological form of nonetransferrin-bound iron, induces intracellular iron overload to cause ferroptosis. Ammonium iron(III) citrate can enhance protein production. Ammonium iron(III) citrate Chemical Structure
  20. GC65163 Ardisiacrispin B Ardisiacrispin B displays cytotoxic effects in multi-factorial drug resistant cancer cells via ferroptotic and apoptotic cell death. Ardisiacrispin B Chemical Structure
  21. GC35398 Arteannuin B Arteannuin B co-occurs with artemisinin, which is the potent antimalarial principle of the Chinese medicinal herb Artemisia annua (Asteraceae). Arteannuin B Chemical Structure
  22. GC35399 Artefenomel

    OZ439

     An antimalarial agent Artefenomel Chemical Structure
  23. GN10647 Artemisinine

    NSC 369397

     Artemisinine Chemical Structure
  24. GC10889 Artesunate

    Artesunic Acid, NSC 712571, WR 256283

     Artesunate is an antimalarial compound and an inhibitor of signal transducer and activator of transcription 3 (STAT-3) and membrane glutathione S-transferase (EXP1). Artesunate Chemical Structure
  25. GC14038 Atorvastatin Calcium

    CI-981; Atorvastatin hemicalcium

     An HMG-CoA reductase inhibitor Atorvastatin Calcium Chemical Structure
  26. GN10158 Baicalein Baicalein (5,6,7-trihydroxyflavone) is a flavonoid compound with multiple biological activities. It is a xanthine oxidase inhibitor with an IC50 value of 3.12μM. Baicalein Chemical Structure
  27. GC45820 Balsalazide-d4 A neuropeptide with diverse biological activities Balsalazide-d4 Chemical Structure
  28. GC11572 Bardoxolone methyl

    Bardoxolone methyl, NSC 713200, RTA 402, TP155

     A synthetic triterpenoid with potent anticancer and antidiabetic activity Bardoxolone methyl Chemical Structure
  29. GC10345 Bay 11-7085

    NK-κB activation inhibitor

     Bay 11-7085 Chemical Structure
  30. GC12698 BAY 87-2243 A HIF-1 inhibitor,potent and selective BAY 87-2243 Chemical Structure
  31. GC52317 BCP-T.A. A ferroptosis inducer BCP-T.A. Chemical Structure
  32. GC42928 BHT

    Butylated Hydroxy Toluene, NSC 6347

     BHT is an antioxidant widely used in foods and in food-related products. BHT is a Ferroptosis inhibitor. BHT Chemical Structure
  33. GC34070 Brusatol

    (+)-Brusatol, NSC 172924

     Brusatol is an Nrf2 inhibitor isolated from Brucea javanica and exhibits significant tumor inhibition in multiple cancers through decreased resistance to cancer oxidative stress injury. Brusatol Chemical Structure
  34. GC74728 Butylated hydroxytoluene-d3 Butylated droxytoluene-d3 is the deuterium labeled Butylated droxytoluene. Butylated hydroxytoluene-d3 Chemical Structure
  35. GC30067 Butylhydroxyanisole (Butylated hydroxyanisole) Butylhydroxyanisole (Butylated hydroxyanisole) (Butylated hydroxyanisole) is an antioxidant used as a food additive preservative. Butylhydroxyanisole (Butylated hydroxyanisole) Chemical Structure
  36. GC91157 C18

    A covalent GPX4 inhibitor

     C18 Chemical Structure
  37. GC47065 CAY10773 A derivative of sorafenib CAY10773 Chemical Structure
  38. GC32723 CDDO-Im (RTA-403)

    CDDO-Imidazolide, RTA 403

     CDDO-Im (RTA-403) (RTA-403) is an activator of Nrf2 and PPAR, with Kis of 232 and 344 nM for PPARα and PPARγ. CDDO-Im (RTA-403) Chemical Structure
  39. GC20109 Cefotiam hexetil hydrochloride

    CTM-HE hydrochloride; SCE-2174 hydrochloride

    Cefotiam hexetil hydrochloride (CTM-HE) is an oral third-generation cephalosporin, which is a prodrug of cefotiam, but has no anti-bacterial property. Cefotiam is an antibiotic.

     Cefotiam hexetil hydrochloride Chemical Structure
  40. GC43231 Cerivastatin (sodium salt)

    BAY-w 6228

     Cerivastatin (sodium salt) is a synthetic lipid-lowering agent and a highly potent, well-tolerated and orally active HMG-CoA reductase inhibitor, with a Ki of 1.3 nM/L. Cerivastatin (sodium salt) Chemical Structure
  41. GC45792 Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III)

    Iron Salophene Complex, N,N'-o-Phenylenebis(salicylideneaminato)iron(III) Chloride

     An inducer of ferroptosis Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III) Chemical Structure
  42. GC35692 Chrysosplenetin

    Chrysosplenol B, Chrysosptertin B, EMD 20940, Polycladin

     A flavonoid with diverse biological activities Chrysosplenetin Chemical Structure
  43. GC10132 Ciclopirox

    HOE 296b

     broad-spectrum antifungal agent Ciclopirox Chemical Structure
  44. GC11120 Ciclopirox ethanolamine Ciclopirox ethanolamine (Ciclopirox ethanolamine) is a synthetic antifungal agent that can be used for superficial mycoses reseaech. Ciclopirox ethanolamine Chemical Structure
  45. GC45764 Ciclopirox-d11 (sodium salt)

    HOE 296b-d11

     A neuropeptide with diverse biological activities Ciclopirox-d11 (sodium salt) Chemical Structure
  46. GC32237 CIL56

    CA3

     An inducer of non-apoptotic cell death; YAP1 (YES related protein 1) targeted inhibitor CIL56 Chemical Structure
  47. GC11908 Cisplatin

    CDDP

     Cisplatin is one of the best and first metal-based chemotherapeutic drugs, which is used for wide range of solid cancers such as testicular, ovarian, bladder, lung, cervical, head and neck cancer, gastric cancer and some other cancers. Cisplatin Chemical Structure
  48. GN10668 Coenzyme Q10

    CoQ10, NSC 140865, Ubidecarenone, Ubiquinone10, Ubiquinone Q10

     Coenzyme Q10 Chemical Structure
  49. GC43297 Coenzyme Q2

    CoQ2, Ubiquinone-2, Ubiquinone Q2

     Coenzyme Q10 is a component of the electron transport chain and participates in aerobic cellular respiration, generating energy in the form of ATP. Coenzyme Q2 Chemical Structure
  50. GC49454 Complex 3 A fluorescent copper complex with anticancer activity Complex 3 Chemical Structure
  51. GC47123 Coumarin-Quinone Conjugate A fluorescent substrate for NADH:ubiquinone oxidoreductases Coumarin-Quinone Conjugate Chemical Structure
  52. GC48954 CP21 An iron chelator CP21 Chemical Structure
  53. GC43329 Cu-ATSM

    copper-ATSM, CuII(atsm)

     The metallo-protein Cu/Zn-superoxide dismutase (SOD1) is a ubiquitous enzyme responsible for scavenging superoxide radicals. Cu-ATSM Chemical Structure
  54. GC52164 Cu-ATSP

    copper-ATSP, CuII(atsp)

     Cu-ATSP, a potent inhibitor of ferroptotic cell death, is almost 20-fold more potent than CuATSM. Cu-ATSP Chemical Structure
  55. GC14787 Curcumin

    Indian Saffron, Turmeric yellow

     A yellow pigment with diverse biological activities Curcumin Chemical Structure
  56. GC40226 Curcumin-d6 Curcumin-d6 is intended for use as an internal standard for the quantification of curcumin by GC- or LC-MS. Curcumin-d6 Chemical Structure
  57. GC10896 Cyclic Pifithrin-α hydrobromide

    Pifithrin-β

     A stable inhibitor of p53 Cyclic Pifithrin-α hydrobromide Chemical Structure
  58. GC17198 Cycloheximide

    Naramycin A; Actidione; 3-[2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]glutarimide

     Cycloheximide is an antibiotic that inhibits protein synthesis at the translation level, acting exclusively on cytoplasmic (80s) ribosomes of eukaryotes. Cycloheximide Chemical Structure
  59. GC33023 D,L-Buthionine-(S,R)-sulfoximine (Butionine sulfoximine)

    NSC 381100

     D,L-Buthionine-(S,R)-sulfoximine (Butionine sulfoximine) is a potent inhibitor of glutamylcysteine synthetase biosynthesis. D,L-Buthionine-(S,R)-sulfoximine (Butionine sulfoximine) Chemical Structure
  60. GC35795 D,L-Buthionine-(S,R)-sulfoximine hydrochloride

    Buthionine sulfoximine hydrochloride; BSO hydrochloride

     D,L-Buthionine-(S,R)-sulfoximine hydrochloride Chemical Structure
  61. GC49868 D-α-Tocopheryl Quinone

    α-Tocopherylquinone, α-Tocoquinone, α-TQ, Tocopherol Quinone

     An oxidative metabolite of vitamin E D-α-Tocopheryl Quinone Chemical Structure
  62. GC11835 Deferasirox

    ICL 670

     Deferasirox is an orally active iron chelator used to treat iron overload diseases. Deferasirox Chemical Structure
  63. GC17412 Deferasirox Fe3+ chelate Deferasirox Fe3+ chelate Chemical Structure
  64. GC18101 Deferiprone

    CGP 37391, DN 18001AF

     Chelating agent Deferiprone Chemical Structure
  65. GC13554 Deferoxamine mesylate

    Ba 33112, DFO, DFOM, DFX, NSC 644468

    Deferoxamine mesylate is a drug that chelates iron by forming a stable complex that prevents the iron from entering into further chemical reactions, and is used for the treatment of chronic iron overload in patients with transfusion-dependent anemias.

     Deferoxamine mesylate Chemical Structure
  66. GC38429 Dihydroartemisinic acid A precursor to artemisinin Dihydroartemisinic acid Chemical Structure
  67. GC35876 DL-Glutamine DL-Glutamine is used for biochemical research and drug synthesis. DL-Glutamine Chemical Structure
  68. GC45995 DO264 An ABHD12 inhibitor DO264 Chemical Structure
  69. GC31940 Docebenone (AA 861)

    A-61589, Docebenone

     Docebenone (AA 861) (AA 861) is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. Docebenone (AA 861) Chemical Structure
  70. GC15399 Dp44mT iron chelator and anticancer agent Dp44mT Chemical Structure
  71. GC49058 DTPA

    Diethylenetriaminepentaacetic Acid, NSC 7340, Pentetic Acid

     DTPA is a compound used to construct magnetic adsorbent, which can simultaneously remove heavy metal and dye from complex wastewater. DTPA Chemical Structure
  72. GC48650 DTUN A lipophilic hyponitrite radical initiator DTUN Chemical Structure
  73. GC10331 Ebselen Ebselen is a selenoorganic compound with glutathione peroxidase-like activity and is an anti-inflammatory and antioxidant agent. Ebselen is an inhibitor of inositol monophosphatase (IMPase) with an IC50 of 1.5μM. Ebselen Chemical Structure
  74. GC16630 Erastin Erastin is a cell-permeable ferroptosis activatior and an antitumor agent that is selective for cell expressing oncogene RAS. Erastin Chemical Structure
  75. GC43623 Erastin2

    35MEW28

     Erastin2 is a potent system xc- inhibitor and ferroptosis-inducing agent. Erastin2 Chemical Structure
  76. GC36011 Ethylenediaminetetraacetic acid trisodium salt Ethylenediaminetetraacetic acid trisodium salt (EDTA trisodium salt) is used to bind metal ions in the practice of chelation therapy, for treating mercury and lead poisoning, used in a similar manner to remove excess iron from the body, for treating the complication of repeated blood transfusions, as would be applied to treat thalassaemia. Ethylenediaminetetraacetic acid trisodium salt Chemical Structure
  77. GC16517 Eugenol naturally occuring scent chemical Eugenol Chemical Structure
  78. GC91783 FA16 FA16 is a ferroptosis inducer and an inhibitor of the system xc- cystine/glutamate transporter. FA16 Chemical Structure
  79. GC91613 FerroLOXIN-1 FerroLOXIN-1 is an inhibitor of the 15-lipoxygenase-2 (15-LO-2) and phosphatidylethanolamine-binding protein 1 (PEBP1) catalytic complex. FerroLOXIN-1 Chemical Structure
  80. GC91623 Ferroptosis Inducer 24 Ferroptosis inducer 24 is an inducer of ferroptosis. Ferroptosis Inducer 24 Chemical Structure
  81. GC91910 Ferroptosis Inhibitor D1 Ferroptosis inhibitor D1 is a free radical scavenger and an inhibitor of ferroptosis. Ferroptosis Inhibitor D1 Chemical Structure
  82. GC74018 Ferroptosis-IN-6 Ferroptosis-IN-6 (compound 13) is a potent inhibitor of Ferroptosis with EC50 of 25.5 nM. Ferroptosis-IN-6 Chemical Structure
  83. GC10380 Ferrostatin-1 (Fer-1)

    Fer-1

    Ferrostatin-1 is a potent inhibitor of ferroptosis with an EC50 of 60 nM.

     Ferrostatin-1 (Fer-1) Chemical Structure
  84. GC40211 Ferrostatin-1 Diyne Ferrostatin-1 diyne is a ferroptosis inhibitor and analog of ferrostatin-1. Ferrostatin-1 Diyne Chemical Structure
  85. GC13139 FG-4592 (ASP1517)

    ASP1517, FG-4592

    FG-4592, as an oral bioavailable hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitor, can promote coordinated erythropoiesis through HIF-mediated transcription.

     FG-4592 (ASP1517) Chemical Structure
  86. GC30039 FIN56 FIN56, a novel ferroptosis inducer, triggers ferroptosis by increasing the degradation of GPX4 . FIN56 Chemical Structure
  87. GC15541 Fluvastatin Sodium An HMG-CoA reductase inhibitor Fluvastatin Sodium Chemical Structure
  88. GC40228 Fluvastatin-d6 (sodium salt) Fluvastatin-d6 is intended for use as an internal standard for the quantification of fluvastatin by GC- or LC-MS. Fluvastatin-d6 (sodium salt) Chemical Structure
  89. GC90713 FSEN1

    An inhibitor of FSP1

     FSEN1 Chemical Structure
  90. GN10388 Gallic acid

    NSC 20103, NSC 674319, 3,4,5Trihydroxybenzoic Acid

     Gallic acid Chemical Structure
  91. GC61436 Gallic acid hydrate Gallic acid (3,4,5-Trihydroxybenzoic acid) hydrate is a natural polyhydroxyphenolic compound and an free radical scavenger to inhibit cyclooxygenase-2 (COX-2). Gallic acid hydrate Chemical Structure
  92. GC11882 GKT137831 GKT137831 (GKT137831) is a selective NADPH oxidase (NOX1/4) inhibitor with Kis of 140 and 110 nM, respectively. GKT137831 Chemical Structure
  93. GC41293 Glutathione ethyl ester

    GSH-EE, GSH ethyl ester, GSH monoethyl ester

    Glutathione (GSH) serves as a nucleophilic co-substrate to glutathione transferase in the detoxification of xenobiotics and is an essential electron donor to glutathione peroxidases in the reduction of hydroperoxides.

     Glutathione ethyl ester Chemical Structure
  94. GC91598 GPX4 16

    Glutathione Peroxidase 4 16

     GPX4 16 is an inhibitor of glutathione peroxidase 4 (GPX4). GPX4 16 Chemical Structure
  95. GC90827 GPX4 24

    A GPX4 inhibitor

     GPX4 24 Chemical Structure
  96. GC92031 GPX4 Inhibitor 17

    Glutathione Peroxidase 4-IN-17; Glutathione Peroxidase 4 Inhibitor 17; GPX4-IN-17

     GPX4 inhibitor 17 is a ferrocene-containing inhibitor of glutathione peroxidase 4 (GPX4) and an inducer of ferroptosis. GPX4 Inhibitor 17 Chemical Structure
  97. GC73589 GPX4-IN-6 GPX4-IN-6 (Compound C25) is a GPX4 covalent inhibitor with an IC50 value of 0.13 μM. GPX4-IN-6 Chemical Structure
  98. GA10942 H-D-Gln-OH

    D-Gln

     H-D-Gln-OH Chemical Structure
  99. GA10750 H-Glu-OH H-Glu-OH Chemical Structure
  100. GC72857 HBED HBED is a potent iron chelator. HBED Chemical Structure
  101. GC14591 Hemin chloride Hemin chloride, a substrate of heme oxygenase (HO)-1, induces HO-1 expression on a variety of cells to exert anti-oxidant and anti-inflammatory roles. Hemin chloride Chemical Structure

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