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Home >> Signaling Pathways >> Metabolism >> Ferroptosis

Ferroptosis

Ferroptosis is a unique iron-dependent form of nonapoptotic cell death. It is triggered by oncogenic RAS-selective lethal small molecule erastin. Acitvation of ferroptosis lead to nonapoptotic destruction of cancer cells.

Products for  Ferroptosis

  1. Cat.No. Product Name Information
  2. GC14049 (-)-Epigallocatechin gallate (EGCG) (-)-Epigallocatechin Gallate sulfate (EGCG) is a major polyphenol in green tea that inhibits cell proliferation and induces apoptosis. In addition, it inhibits the activity of glutamate dehydrogenase 1/2 (GDH1/2, GLUD1/2) .. (-)-Epigallocatechin gallate (EGCG) Chemical Structure
  3. GC45248 (-)-FINO2 (-)-FINO2 is a ferroptosis-inducing peroxide compound that indirectly inhibits glutathione peroxidase 4 (GPX4) and oxidizes iron. (-)-FINO2 Chemical Structure
  4. GC34980 (E)-Ferulic acid (E)-Ferulic acid is a isomer of Ferulic acid which is an aromatic compound, abundant in plant cell walls. (E)-Ferulic acid causes the phosphorylation of β-catenin, resulting in proteasomal degradation of β-catenin and increases the expression of pro-apoptotic factor Bax and decreases the expression of pro-survival factor survivin. (E)-Ferulic acid shows a potent ability to remove reactive oxygen species (ROS) and inhibits lipid peroxidation. (E)-Ferulic acid exerts both anti-proliferation and anti-migration effects in the human lung cancer cell line H1299. (E)-Ferulic acid Chemical Structure
  5. GA11210 (H-Cys-OH)2 (H-Cys-OH)2 Chemical Structure
  6. GC52290 (R)-HTS-3 An inhibitor of LPCAT3 (R)-HTS-3 Chemical Structure
  7. GC46352 (S)-DO271 An inactive control for DO264 (S)-DO271 Chemical Structure
  8. GC49034 1(R)-(Trifluoromethyl)oleyl alcohol An oleic acid analog 1(R)-(Trifluoromethyl)oleyl alcohol Chemical Structure
  9. GC42039 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PC 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PC is a phospholipid that contains stearic acid at the sn-1 position and 15(S)-HETE at the sn-2 position. 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PC Chemical Structure
  10. GC42040 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE is a phospholipid that contains stearic acid at the sn-1 position and 15(S)-HETE at the sn-2 position. 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE Chemical Structure
  11. GC49730 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE-d11 An internal standard for the quantification of 1-stearoyl-2-15(S)-HETE-sn-glycero-3-PE 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE-d11 Chemical Structure
  12. GC42041 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PC 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PC is a phospholipid that contains stearic acid at the sn-1 position and 15(S)-HpETE at the sn-2 position. 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PC Chemical Structure
  13. GC42042 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PE 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PE is a phospholipid that contains stearic acid at the sn-1 position and 15(S)-HpETE at the sn-2 position. 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PE Chemical Structure
  14. GC52413 5-Aminosalicylic Acid-d7 An internal standard for the quantification of 5-aminosalicylic acid 5-Aminosalicylic Acid-d7 Chemical Structure
  15. GC11786 Acetylcysteine

    Acetylcysteine is the N-acetyl derivative of CYSTEINE.

     Acetylcysteine Chemical Structure
  16. GC15130 Alogliptin (SYR-322) Alogliptin (SYR-322) Chemical Structure
  17. GC61895 Ammonium iron(III) citrate Ammonium iron(III) citrate (Ammonium ferric citrate), a physiological form of nonetransferrin-bound iron, induces intracellular iron overload to cause ferroptosis. Ammonium iron(III) citrate can enhance protein production. Ammonium iron(III) citrate Chemical Structure
  18. GC65163 Ardisiacrispin B Ardisiacrispin B displays cytotoxic effects in multi-factorial drug resistant cancer cells via ferroptotic and apoptotic cell death. Ardisiacrispin B Chemical Structure
  19. GC35398 Arteannuin B Arteannuin B co-occurs with artemisinin, which is the potent antimalarial principle of the Chinese medicinal herb Artemisia annua (Asteraceae). Arteannuin B Chemical Structure
  20. GC35399 Artefenomel An antimalarial agent Artefenomel Chemical Structure
  21. GN10647 Artemisinine Artemisinine Chemical Structure
  22. GC10889 Artesunate Derivative of the natural product artemisinin Artesunate Chemical Structure
  23. GC14038 Atorvastatin Calcium An HMG-CoA reductase inhibitor Atorvastatin Calcium Chemical Structure
  24. GN10158 Baicalein Baicalein Chemical Structure
  25. GC11572 Bardoxolone methyl A synthetic triterpenoid with potent anticancer and antidiabetic activity Bardoxolone methyl Chemical Structure
  26. GC10345 Bay 11-7085

    NK-κB activation inhibitor

     Bay 11-7085 Chemical Structure
  27. GC12698 BAY 87-2243 A HIF-1 inhibitor,potent and selective BAY 87-2243 Chemical Structure
  28. GC52317 BCP-T.A. A ferroptosis inducer BCP-T.A. Chemical Structure
  29. GC42928 BHT BHT is an antioxidant widely used in foods and in food-related products. BHT is a Ferroptosis inhibitor. BHT Chemical Structure
  30. GC34070 Brusatol (NSC 172924) Brusatol (NSC 172924) (NSC172924) is a unique inhibitor of the Nrf2 pathway that sensitizes a broad spectrum of cancer cells to Cisplatin and other chemotherapeutic agents. Brusatol (NSC 172924) enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism. Brusatol (NSC 172924) can be developed into an adjuvant chemotherapeutic agent. Brusatol (NSC 172924) increases cellular apoptosis. Brusatol (NSC 172924) Chemical Structure
  31. GC30067 Butylhydroxyanisole (Butylated hydroxyanisole) Butylhydroxyanisole (Butylated hydroxyanisole) (Butylated hydroxyanisole) is an antioxidant used as a food additive preservative. Butylhydroxyanisole (Butylated hydroxyanisole) Chemical Structure
  32. GC47065 CAY10773 A derivative of sorafenib CAY10773 Chemical Structure
  33. GC32723 CDDO-Im (RTA-403) CDDO-Im (RTA-403) (RTA-403) is an activator of Nrf2 and PPAR, with Kis of 232 and 344 nM for PPARα and PPARγ. CDDO-Im (RTA-403) Chemical Structure
  34. GC43231 Cerivastatin (sodium salt) Cerivastatin (sodium salt) is a synthetic lipid-lowering agent and a highly potent, well-tolerated and orally active HMG-CoA reductase inhibitor, with a Ki of 1.3 nM/L. Cerivastatin (sodium salt) Chemical Structure
  35. GC45792 Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III) An inducer of ferroptosis Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III) Chemical Structure
  36. GC35692 Chrysosplenetin A flavonoid with diverse biological activities Chrysosplenetin Chemical Structure
  37. GC10132 Ciclopirox broad-spectrum antifungal agent Ciclopirox Chemical Structure
  38. GC11120 Ciclopirox ethanolamine Ciclopirox ethanolamine (Ciclopirox ethanolamine) is a synthetic antifungal agent that can be used for superficial mycoses reseaech. Ciclopirox ethanolamine Chemical Structure
  39. GC32237 CIL56 An inducer of non-apoptotic cell death; YAP1 (YES related protein 1) targeted inhibitor CIL56 Chemical Structure
  40. GC11908 Cisplatin

    Cisplatin is one of the best and first metal-based chemotherapeutic drugs, which is used for wide range of solid cancers such as testicular, ovarian, bladder, lung, cervical, head and neck cancer, gastric cancer and some other cancers.

     Cisplatin Chemical Structure
  41. GN10668 Coenzyme Q10 Coenzyme Q10 Chemical Structure
  42. GC43297 Coenzyme Q2 Coenzyme Q10 is a component of the electron transport chain and participates in aerobic cellular respiration, generating energy in the form of ATP. Coenzyme Q2 Chemical Structure
  43. GC49454 Complex 3 A fluorescent copper complex with anticancer activity Complex 3 Chemical Structure
  44. GC47123 Coumarin-Quinone Conjugate A fluorescent substrate for NADH:ubiquinone oxidoreductases Coumarin-Quinone Conjugate Chemical Structure
  45. GC48954 CP21 An iron chelator CP21 Chemical Structure
  46. GC43329 Cu-ATSM The metallo-protein Cu/Zn-superoxide dismutase (SOD1) is a ubiquitous enzyme responsible for scavenging superoxide radicals. Cu-ATSM Chemical Structure
  47. GC52164 Cu-ATSP Cu-ATSP, a potent inhibitor of ferroptotic cell death, is almost 20-fold more potent than CuATSM. Cu-ATSP Chemical Structure
  48. GC14787 Curcumin A yellow pigment with diverse biological activities Curcumin Chemical Structure
  49. GC40226 Curcumin-d6 Curcumin-d6 is intended for use as an internal standard for the quantification of curcumin by GC- or LC-MS. Curcumin-d6 Chemical Structure
  50. GC10896 Cyclic Pifithrin-α hydrobromide A stable inhibitor of p53 Cyclic Pifithrin-α hydrobromide Chemical Structure
  51. GC17198 Cycloheximide

    Cycloheximide is an antibiotic that inhibits protein synthesis at the translation level, acting exclusively on cytoplasmic (80s) ribosomes of eukaryotes.

     Cycloheximide Chemical Structure
  52. GC33023 D,L-Buthionine-(S,R)-sulfoximine (Butionine sulfoximine) D,L-Buthionine-(S,R)-sulfoximine (Butionine sulfoximine) is a potent inhibitor of glutamylcysteine synthetase biosynthesis. D,L-Buthionine-(S,R)-sulfoximine (Butionine sulfoximine) Chemical Structure
  53. GC35795 D,L-Buthionine-(S,R)-sulfoximine hydrochloride D,L-Buthionine-(S,R)-sulfoximine hydrochloride Chemical Structure
  54. GC49868 D-α-Tocopheryl Quinone An oxidative metabolite of vitamin E D-α-Tocopheryl Quinone Chemical Structure
  55. GC11835 Deferasirox

    Oral iron chelator

     Deferasirox Chemical Structure
  56. GC17412 Deferasirox Fe3+ chelate Deferasirox Fe3+ chelate Chemical Structure
  57. GC18101 Deferiprone Chelating agent Deferiprone Chemical Structure
  58. GC13554 Deferoxamine mesylate

    Deferoxamine mesylate is a drug that chelates iron by forming a stable complex that prevents the iron from entering into further chemical reactions, and is used for the treatment of chronic iron overload in patients with transfusion-dependent anemias.

     Deferoxamine mesylate Chemical Structure
  59. GC38429 Dihydroartemisinic acid A precursor to artemisinin Dihydroartemisinic acid Chemical Structure
  60. GC35876 DL-Glutamine DL-Glutamine is used for biochemical research and drug synthesis. DL-Glutamine Chemical Structure
  61. GC45995 DO264 An ABHD12 inhibitor DO264 Chemical Structure
  62. GC31940 Docebenone (AA 861) Docebenone (AA 861) (AA 861) is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. Docebenone (AA 861) Chemical Structure
  63. GC15399 Dp44mT iron chelator and anticancer agent Dp44mT Chemical Structure
  64. GC49058 DTPA DTPA is a compound used to construct magnetic adsorbent, which can simultaneously remove heavy metal and dye from complex wastewater. DTPA Chemical Structure
  65. GC48650 DTUN A lipophilic hyponitrite radical initiator DTUN Chemical Structure
  66. GC10331 Ebselen A peroxynitrite scavenger Ebselen Chemical Structure
  67. GC16630 Erastin

    Erastin is a cell-permeable ferroptosis activatior and antitumor agent.

     Erastin Chemical Structure
  68. GC43623 Erastin2 Erastin2 is a potent system xc- inhibitor and ferroptosis-inducing agent [1]. Erastin2 Chemical Structure
  69. GC36011 Ethylenediaminetetraacetic acid trisodium salt Ethylenediaminetetraacetic acid trisodium salt (EDTA trisodium salt) is used to bind metal ions in the practice of chelation therapy, for treating mercury and lead poisoning, used in a similar manner to remove excess iron from the body, for treating the complication of repeated blood transfusions, as would be applied to treat thalassaemia. Ethylenediaminetetraacetic acid trisodium salt Chemical Structure
  70. GC16517 Eugenol naturally occuring scent chemical Eugenol Chemical Structure
  71. GC10380 Ferrostatin-1 (Fer-1)

    A ferroptosis inhibitor

     Ferrostatin-1 (Fer-1) Chemical Structure
  72. GC40211 Ferrostatin-1 Diyne Ferrostatin-1 diyne is a ferroptosis inhibitor and analog of ferrostatin-1. Ferrostatin-1 Diyne Chemical Structure
  73. GC13139 FG-4592 (ASP1517) An inhibitor of HIF-PH enzymes FG-4592 (ASP1517) Chemical Structure
  74. GC30039 FIN56

    FIN56, a novel ferroptosis inducer, triggers ferroptosis by increasing the degradation of GPX4 .

     FIN56 Chemical Structure
  75. GC15541 Fluvastatin Sodium An HMG-CoA reductase inhibitor Fluvastatin Sodium Chemical Structure
  76. GN10388 Gallic acid Gallic acid Chemical Structure
  77. GC61436 Gallic acid hydrate Gallic acid (3,4,5-Trihydroxybenzoic acid) hydrate is a natural polyhydroxyphenolic compound and an free radical scavenger to inhibit cyclooxygenase-2 (COX-2). Gallic acid hydrate Chemical Structure
  78. GC11882 GKT137831 GKT137831 (GKT137831) is a selective NADPH oxidase (NOX1/4) inhibitor with Kis of 140 and 110 nM, respectively. GKT137831 Chemical Structure
  79. GC41293 Glutathione ethyl ester

    Glutathione (GSH) serves as a nucleophilic co-substrate to glutathione transferase in the detoxification of xenobiotics and is an essential electron donor to glutathione peroxidases in the reduction of hydroperoxides.

     Glutathione ethyl ester Chemical Structure
  80. GC49697 GPX4 Inhibitor 26a A GPX4 inhibitor GPX4 Inhibitor 26a Chemical Structure
  81. GA11257 H-Cys-OH H-Cys-OH Chemical Structure
  82. GA10942 H-D-Gln-OH H-D-Gln-OH Chemical Structure
  83. GA10750 H-Glu-OH H-Glu-OH Chemical Structure
  84. GC14591 Hemin chloride Hemin chloride is an iron-containing porphyrin. Hemin chloride Chemical Structure
  85. GC15972 Idebenone synthetic analog of coenzyme Q10 (CoQ10) Idebenone Chemical Structure
  86. GC45928 iFSP1

    An inhibitor of AIFM2/FSP1

     iFSP1 Chemical Structure
  87. GC45793 IM-93 A dual inhibitor of ferroptosis and NETosis IM-93 Chemical Structure
  88. GC52190 Imidazole Ketone Erastin Imidazole Ketone Erastin is a ferroptosis inducer. Imidazole Ketone Erastin Chemical Structure
  89. GC47477 JKE-1674 A GPX4 inhibitor and active metabolite of ML-210 JKE-1674 Chemical Structure
  90. GC47478 JKE-1716 A GPX4 inhibitor JKE-1716 Chemical Structure
  91. GC33098 L-Buthionine-(S,R)-sulfoximine (L-Butionine sulfoximine) L-Buthionine-(S,R)-sulfoximine (L-Butionine sulfoximine) is a cell-permeable, potent, fast acting and irreversible inhibitor of g-glutamylcysteine synthetase and depletes cellular glutathione levels. The IC50 value of L-Buthionine-(S,R)-sulfoximine (L-Butionine sulfoximine) on melanoma, breast and ovarian tumor specimens are 1.9 μM, 8.6 μM, and 29 μM, respectively. L-Buthionine-(S,R)-sulfoximine (L-Butionine sulfoximine) Chemical Structure
  92. GC62643 L-Buthionine-(S,R)-sulfoximine hydrochloride L-Buthionine-(S,R)-sulfoximine hydrochloride is a cell-permeable, potent, fast acting, orally active and irreversible inhibitor of g-glutamylcysteine synthetase and depletes cellular glutathione levels. L-Buthionine-(S,R)-sulfoximine hydrochloride Chemical Structure
  93. GC30788 L-Glutamic acid monosodium salt (Monosodium glutamate) L-Glutamic acid monosodium salt (Monosodium glutamate) acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). L-Glutamic acid monosodium salt (Monosodium glutamate) Chemical Structure
  94. GC64352 L-Glutamic acid-15N L-Glutamic acid-15N Chemical Structure
  95. GC65095 L-Glutamic acid-d5 L-Glutamic acid-d5 is the deuterium labeled L-Glutamic acid. L-Glutamic acid-d5 Chemical Structure
  96. GC17498 L-Glutamine Non-essential amino acid L-Glutamine Chemical Structure
  97. GC65068 L-Glutamine 15N L-Glutamine 15N Chemical Structure
  98. GC12203 L-Glutathione Reduced Used to elute GST from glutathione agarose L-Glutathione Reduced Chemical Structure
  99. GC49560 L6H21 L6H21, a Chalcone derivative, is an orally active, potent and specific myeloid differentiation 2 (MD-2) inhibitor. L6H21 Chemical Structure
  100. GC14827 Linagliptin (BI-1356) A potent DPP-4 inhibitor Linagliptin (BI-1356) Chemical Structure
  101. GC15681 Liproxstatin-1

    Liproxstatin-1 is a potent inhibitor of ferroptosis and can protect against ferroptosis-inducing agents, such as buthionine sulfoxamine (BSO), erastin, and (1S,3R)-RSL3 (RSL3).

     Liproxstatin-1 Chemical Structure

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