Fluorescent Probes

S1P lyase fluorogenic substrate is a substrate of S1P lyase, leading to the production of the fluorescent product umbelliferone (7-hydroxycoumarin) under appropriate conditions.

Suc-Leu-Tyr-AMC, a fluorescent substrate for calpain I and II and papain (cysteine protease) measuring the chymotrypsin-like peptidase activity of the 20S proteasome, emits bright fluorescence has been used extensively for calpain I and II and papain evaluation (Ex/Em: 360/460nm) .

Suc-YVAD-AMC is a fluorogenic substrate for caspase-1.

SureLight? 488 is a bright green fluorescent dye with excitation suited to the 488 nm laser line, fluorescent microscopy, and flow cytometry.

Tetramethylrhodamine isothiocyanate (TRITC) is an amine-reactive derivative of rhodamine that is used as a fluorescent label for antibodies and other probes (ex/em max = 552/575 nm).

The rapid, selective, and sensitive sensing of thiols is important in diverse areas of research.

TMB is an aromatic amine that undergoes oxidation by the higher oxidation states of heme peroxidases (compounds I and II) thereby serving as a reducing co-substrate.

WSP-5 (Washington State Probe-5) is a fluorescent probe containing active disulfide groups, specifically designed for rapid detection of hydrogen sulfide (H 2 S) in biological samples and within cells.

Z-IETD-AFC is a fluorogenic substrate for caspase-8 and granzyme B.

Zinc (Zn)-fluorophore 1(Zinpyr-1, ZP1), a fluorescent probe for zinc detection, emits bright fluorescence has been used extensively for zinc labeling (Ex/Em: 515nm/531nm) (ε =79,000/M/cm; pKa = 8.4; Φ = 0.38).

Z-LLE-AMC is a fluorescent substrate that, when hydrolyzed by specific proteases (20S proteasome, 26S proteasome), releases AMC with blue fluorescence (excitation at 340–360nm, emission at 440–460nm), which is used to monitor protease activity levels.

Z-LLL-AMC is a fluorogenic substrate for the chymotrypsin-like activity of the 26S proteasome or 20S proteolytic core.

Z-VDVAD-AFC is a fluorogenic substrate for caspase-2.

(+)-Biotin 4-amidobenzoic acid is a substrate of biotinidase, which cleaves biotin amide to give biotin in vivo.

1,6-Diphenyl-1,3,5-hexatriene is a fluorescent probe for lipid monolayers and bilayer membranes (with maximum excitation and emission wavelengths of 360/430nm).

Gly-Arg-AMC (hydrochloride) is a fluorescent substrate for Cathepsin C.

A solvatochromic fluorescent probe